公开(公告)号：US20060014731A1

公开(公告)日：2006-01-19

申请号：US11108165

申请日：2005-04-14

申请人： Julian Adams ,  Yun Gao ,  Asimina Georges Evangelinos ,  Louis Grenier ,  Roger Pak ,  James Porter ,  James Wright

发明人： Julian Adams ,  Yun Gao ,  Asimina Georges Evangelinos ,  Louis Grenier ,  Roger Pak ,  James Porter ,  James Wright

IPC分类号： C07D225/04 ,  C07D491/02 ,  A61K31/33

CPC分类号： A61K31/395 ,  C07D211/60 ,  C07D225/06 ,  C07F9/6561

摘要： The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.

公开(公告)号：US20050288269A1

公开(公告)日：2005-12-29

申请号：US11107404

申请日：2005-04-14

申请人： Julian Adams ,  Yun Gao ,  Asimina Georges Evangelinos ,  Louis Grenier ,  Roger Pak ,  James Porter ,  James Wright

发明人： Julian Adams ,  Yun Gao ,  Asimina Georges Evangelinos ,  Louis Grenier ,  Roger Pak ,  James Porter ,  James Wright

IPC分类号： C07D211/60 ,  C07D225/06 ,  C07D498/08 ,  C07F5/02 ,  C07F9/6561 ,  A61K31/33 ,  C07D225/04

CPC分类号： A61K31/395 ,  C07D211/60 ,  C07D225/06 ,  C07F9/6561

摘要： The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.

公开(公告)号：US20060020004A1

公开(公告)日：2006-01-26

申请号：US11155314

申请日：2005-06-17

申请人： Burton Christensen ,  Michael Foley ,  Asimina Georges Evangelinos ,  Tao Liu ,  James Porter ,  Amy Ripka ,  Linping Zhang

发明人： Burton Christensen ,  Michael Foley ,  Asimina Georges Evangelinos ,  Tao Liu ,  James Porter ,  Amy Ripka ,  Linping Zhang

IPC分类号： A61K31/42 ,  C07D261/10 ,  C07D261/12 ,  C07D413/02

CPC分类号： C07D261/02 ,  C07D413/12

摘要： The present invention relates to antibiotic compounds and intermediates useful in their preparation. Many of the antibiotic compounds contain a substituted isoxazolidine ring. The invention also relates to pharmaceutical compositions containing a compound of the invention. The invention further provides processes for the preparation of compounds of the invention, and methods for their use as therapeutic agents.

摘要翻译： 本发明涉及可用于其制备的抗生素化合物和中间体。 许多抗生素化合物含有取代的异恶唑烷环。 本发明还涉及含有本发明化合物的药物组合物。 本发明还提供了制备本发明化合物的方法及其用作治疗剂的方法。

公开(公告)号：US20060025460A1

公开(公告)日：2006-02-02

申请号：US11156364

申请日：2005-06-17

申请人： Alfredo Castro ,  Wei Deng ,  Kristopher Depew ,  Michael Foley ,  Christian Fritz ,  Asimina Georges Evangelinos ,  Michael Grogan ,  Nafeeza Hafeez ,  Edward Holson ,  Brian Hopkins ,  Nii Koney ,  Tao Liu ,  David Mann ,  Lisa Marcaurelle ,  Daniel Snyder ,  Dennis Underwood ,  Andrew Wylie ,  Lin-Chen Yu ,  Linping Zhang

发明人： Alfredo Castro ,  Wei Deng ,  Kristopher Depew ,  Michael Foley ,  Christian Fritz ,  Asimina Georges Evangelinos ,  Michael Grogan ,  Nafeeza Hafeez ,  Edward Holson ,  Brian Hopkins ,  Nii Koney ,  Tao Liu ,  David Mann ,  Lisa Marcaurelle ,  Daniel Snyder ,  Dennis Underwood ,  Andrew Wylie ,  Lin-Chen Yu ,  Linping Zhang

IPC分类号： C07D261/02 ,  A61K31/42

CPC分类号： C07D261/02 ,  C07D261/18 ,  C07D413/10 ,  C07D413/12 ,  C07D417/12 ,  C07D498/04

摘要： One aspect of the present invention relates to heterocyclic compounds that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising a heterocyclic compound of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.