- 专利标题: Systems and methods of identifying biomarkers for subsequent screening and monitoring of diseases
-
申请号: US11232597申请日: 2005-09-22
-
公开(公告)号: US20060068373A1公开(公告)日: 2006-03-30
- 发明人: Arijit Bose , Nazneen Aziz
- 申请人: Arijit Bose , Nazneen Aziz
- 主分类号: C12Q1/00
- IPC分类号: C12Q1/00 ; C12Q1/68 ; C12M1/34
摘要:
A system for generating an image of ultrastructural biomarkers from a biological sample is provided. The system includes a grid onto which a sample to be imaged may be placed and a cryogenic reservoir into which the grid and sample may be immersed for vitrification of the sample. The system also includes a stage onto which the grid and sample may be situated for subsequent imaging in a high contrast imager to permit identification of ultrastructural biomarkers therein. A method for generating an image of ultrastructural biomarkers from a biological sample is also provided. The generated image of ultrastructural biomarkers may be used subsequently for screening and monitoring diseases, evaluating drug and therapeutic efficacy, and assessing risks associated with a drug or therapeutic candidate, among other things.