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    Systems and methods of identifying biomarkers for subsequent screening and monitoring of diseases
    3.
    发明授权
    Systems and methods of identifying biomarkers for subsequent screening and monitoring of diseases 失效
    识别生物标志物用于随后筛选和监测疾病的系统和方法

    公开(公告)号：US07507533B2

    公开(公告)日：2009-03-24

    申请号：US11232597

    申请日：2005-09-22

    申请人： Arijit Bose ,  Nazneen Aziz

    发明人： Arijit Bose ,  Nazneen Aziz

    IPC分类号： C12Q1/00

    CPC分类号： G01N1/42 ,  B01L3/022 ,  G01N21/6428 ,  G01N21/6456 ,  G01N33/68 ,  G01N2001/2873 ,  H01J2237/2001 ,  H01J2237/204

    摘要： A system for generating an image of ultrastructural biomarkers from a biological sample is provided. The system includes a grid onto which a sample to be imaged may be placed and a cryogenic reservoir into which the grid and sample may be immersed for vitrification of the sample. The system also includes a stage onto which the grid and sample may be situated for subsequent imaging in a high contrast imager to permit identification of ultrastructural biomarkers therein. A method for generating an image of ultrastructural biomarkers from a biological sample is also provided. The generated image of ultrastructural biomarkers may be used subsequently for screening and monitoring diseases, evaluating drug and therapeutic efficacy, and assessing risks associated with a drug or therapeutic candidate, among other things.

    摘要翻译： 提供了一种用于从生物样品生成超微结构生物标志物的图像的系统。 该系统包括可以放置要成像的样品的栅格和可以将栅格和样品浸入其中的低温储存器，用于玻璃化样品。 该系统还包括一个阶段，栅格和样本可以位于该阶段，用于在高对比度成像仪中随后成像，以允许在其中识别超微结构生物标志物。 还提供了用于从生物样品生成超微结构生物标志物的图像的方法。 生成的超微结构生物标志物的图像可以随后用于筛选和监测疾病，评估药物和治疗功效，以及评估与药物或治疗候选物相关的风险等。

    Identification of Biomarkers for Screening and Monitoring of Prostate Cancer and Prostate Related Diseases
    6.
    发明申请
    Identification of Biomarkers for Screening and Monitoring of Prostate Cancer and Prostate Related Diseases 审中-公开
    鉴定用于筛查和监测前列腺癌和前列腺相关疾病的生物标志物

    公开(公告)号：US20100216247A1

    公开(公告)日：2010-08-26

    申请号：US12622291

    申请日：2009-11-19

    申请人： Arijit Bose ,  Nazneen Aziz ,  Ashish Jha

    发明人： Arijit Bose ,  Nazneen Aziz ,  Ashish Jha

    IPC分类号： G01N33/48

    CPC分类号： G01N33/57434

    摘要： A system and method for determining presence of prostate cancer or prostate related diseases is provided. The method includes first obtaining a test sample from a test subject. Next, at least one ultrastructural biomarker indicative of prostate cancer within the sample may be identified. Thereafter, qualitative or quantitative data from the ultrastructural biomarker in the test sample can be obtained. The qualitative or quantitative data of the biomarker in the sample from the test subject can then be compared to that in a sample from a control subject for variations. The presence of qualitative and quantitative variations can act as a determinant for prostate cancer or prostate related diseases.

    摘要翻译： 提供了一种用于确定前列腺癌或前列腺相关疾病的存在的系统和方法。 该方法包括首先从测试对象获得测试样本。 接下来，可以鉴定至少一个指示样品中前列腺癌的超微结构生物标志物。 此后，可以获得来自测试样品中的超微结构生物标志物的定性或定量数据。 然后可以将来自测试对象的样品中生物标志物的定性或定量数据与来自对照受试者的样品进行比较。 定性和定量变异的存在可以作为前列腺癌或前列腺相关疾病的决定因素。

    CYP1B1 nucleic acids and methods of use
    7.
    发明授权
    CYP1B1 nucleic acids and methods of use 有权
    CYP1B1核酸及其使用方法

    公开(公告)号：US07241742B2

    公开(公告)日：2007-07-10

    申请号：US09999686

    申请日：2001-10-31

    申请人： Nazneen Aziz ,  Mary Lynne Hedley ,  Robert G. Urban ,  Andrew J. Tomlinson ,  Geoffrey Cole

    发明人： Nazneen Aziz ,  Mary Lynne Hedley ,  Robert G. Urban ,  Andrew J. Tomlinson ,  Geoffrey Cole

    IPC分类号： A01N43/04 ,  A01N63/00 ,  A61K38/43 ,  C07H21/04 ,  C12P21/06 ,  C12N15/09 ,  C12N15/12 ,  C12N12/52

    CPC分类号： C12N9/0077

    摘要： The present invention provides nucleic acids containing transcriptional units that encode CYP1B1 polypeptides or portions thereof, wherein the transcriptional units lack sequences found in the untranslated region (UTR) of naturally occurring forms of the CYP1B1 transcript. The nucleic acids of the invention lack translational repressor elements and thus provide for a system of enhanced translation of the CYP1B1 polypeptide or portions thereof. Also disclosed are methods of administering nucleic acids to a mammal and use in the treatment of proliferative disorders or cancer.

    摘要翻译： 本发明提供含有编码CYP1B1多肽或其部分的转录单位的核酸，其中转录单位缺少在非翻译区（UTR）中发现CYP1B1转录本天然存在形式的序列。 本发明的核酸缺乏翻译阻遏物元件，因此提供了CYP1B1多肽或其部分的增强翻译的系统。 还公开了向哺乳动物施用核酸并用于治疗增殖性疾病或癌症的方法。

    Methods and compositions for treating glucose-associated conditions, metabolic syndrome, dyslipidemias and other conditions
    8.
    发明申请
    Methods and compositions for treating glucose-associated conditions, metabolic syndrome, dyslipidemias and other conditions 审中-公开
    用于治疗葡萄糖相关病症，代谢综合征，血脂异常和其他病症的方法和组合物

    公开(公告)号：US20060094693A1

    公开(公告)日：2006-05-04

    申请号：US11233532

    申请日：2005-09-21

    申请人： Nazneen Aziz ,  Michael Jesson ,  Paul McLean ,  Glenn Miller ,  Barry Jones

    发明人： Nazneen Aziz ,  Michael Jesson ,  Paul McLean ,  Glenn Miller ,  Barry Jones

    IPC分类号： A61K31/69

    CPC分类号： A61K38/28 ,  A61K31/69

    摘要： The invention relates, in part, to of Glu-boroPro containing compounds and methods of use thereof in the prevention or management of conditions that are associated with impaired glucose tolerance such as diabetes. The invention also relates to compositions of Glu-boroPro containing compounds and methods of use thereof in the prevention or management of conditions such as metabolic syndrome, dyslipidemias, inflammation, cardiovascular disorders such as hypertension and atherosclerosis, and to reduce body weight or prevent weight gain. The compounds of the invention are also useful in lowering levels of triglycerides, free fatty acids, C-reactive protein (CRP), HbA1C, total glycosylated hemoglobin (TGHb), in increasing insulin sensitivity index and in stimulating insulin release.

    摘要翻译： 本发明部分涉及含有Glu-boroPro的化合物及其用于预防或治疗与葡萄糖耐量异常相关的病症如糖尿病的病症的方法。 本发明还涉及含有Glu-boroPro的化合物的组合物及其在预防或治疗诸如代谢综合征，血脂异常，炎症，心血管疾病如高血压和动脉粥样硬化等疾病中的用途，以及减轻体重或防止体重增加 。 本发明的化合物还可用于降低甘油三酯，游离脂肪酸，C-反应蛋白（CRP），HbA 1 C，总糖基化血红蛋白（TGHb）在增加的胰岛素敏感性指数中的水平，以及 在刺激胰岛素释放。