发明申请
US20060148073A1 Enhancement of adenoviral oncolytic activity in prostate cells by modification of the e1a gene product
有权
通过修饰e1a基因产物增强前列腺细胞中的腺病毒溶瘤活性
- 专利标题： Enhancement of adenoviral oncolytic activity in prostate cells by modification of the e1a gene product
- 专利标题（中）： 通过修饰e1a基因产物增强前列腺细胞中的腺病毒溶瘤活性
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申请号： US10523899申请日： 2003-08-08
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公开(公告)号： US20060148073A1公开(公告)日： 2006-07-06
- 发明人: Ronald Rodriguez , Ying Li
- 申请人： Ronald Rodriguez , Ying Li
- 申请人地址： US MD BALTIMORE
- 专利权人： JOHNS HOPKINS UNIVERSITY
- 当前专利权人： JOHNS HOPKINS UNIVERSITY
- 当前专利权人地址： US MD BALTIMORE
- 国际申请： PCT/US03/25171 WO 20030808
- 主分类号： C12Q1/70
- IPC分类号： C12Q1/70 ; C12Q1/68 ; C12N15/63 ; C12N15/74 ; C12N15/00 ; C12N15/70 ; C12N15/09
摘要：
The present invention relates to compositions and methods for enhancing the oncolytic activity of replication-competent, target cell-specific adenovirus vectors by modification of the E1A gene product. The target cell-specific replication-competent adenovirus vectors comprise a chimera of an adenovirus gene essential for replication, preferably an early gene, and the Androgen receptor (or a portion thereof) under the transcriptional control of a cell type-specific transcriptional regulatory element (TRE). By providing for cell type-specific transcription through the use of one or more cell type-specific TREs, the adenovirus vectors effect prostate-specific cytotoxicity due to selective replication.