发明申请
US20060228359A1 Antibodies to Myeloid Progenitor Inhibitory Factor-1 (MPIF-1)
失效
骨髓祖细胞抑制因子-1(MPIF-1)抗体
- 专利标题: Antibodies to Myeloid Progenitor Inhibitory Factor-1 (MPIF-1)
- 专利标题(中): 骨髓祖细胞抑制因子-1(MPIF-1)抗体
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申请号: US11381977申请日: 2006-05-05
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公开(公告)号: US20060228359A1公开(公告)日: 2006-10-12
- 发明人: Reiner Gentz , Brent Kreider , Jun Zhang , Michael Antonaccio , Donna Mendrik , Pablo Jimenez , Vikram Patel , Craig Rosen , Mark Adams , Haodong Li , Steven Ruben
- 申请人: Reiner Gentz , Brent Kreider , Jun Zhang , Michael Antonaccio , Donna Mendrik , Pablo Jimenez , Vikram Patel , Craig Rosen , Mark Adams , Haodong Li , Steven Ruben
- 申请人地址: US MD Rockville
- 专利权人: Human Genome Sciences, Inc.
- 当前专利权人: Human Genome Sciences, Inc.
- 当前专利权人地址: US MD Rockville
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; G01N33/53 ; C12N5/06 ; C07K16/24
摘要:
There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ and chemokine β1(CKβ1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
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