发明申请
US20060257404A1 Modulators of the P2Y10 receptor useful in altering T lymphocyte function
审中-公开
P2Y10受体的调节剂可用于改变T淋巴细胞功能
- 专利标题： Modulators of the P2Y10 receptor useful in altering T lymphocyte function
- 专利标题（中）： P2Y10受体的调节剂可用于改变T淋巴细胞功能
-
申请号： US11489829申请日： 2006-07-20
-
公开(公告)号： US20060257404A1公开(公告)日： 2006-11-16
- 发明人: James Burke , Violetta Iotzova
- 申请人： James Burke , Violetta Iotzova
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; G01N33/567 ; C07K16/28
摘要：
The present invention relates to modulators of P2Y10. Various modulators are disclosed, including an antibody that binds specifically to P2Y10. The present invention also relates to methods of activating resting T lymphocytes and inhibiting the proliferation of activated T lymphocytes. Methods of upregulating trascription of P2Y10 mRNA in a resting T lymphocyte, methods of inducing expression of P2Y10 on the surface of a resting T lymphocyte and methods of activating a T lymphocyte are disclosed. Also disclosed are pharmaceuticals and methods of treating an immune disease.