公开(公告)号：US06713515B2

公开(公告)日：2004-03-30

申请号：US09951306

申请日：2001-09-13

申请人： Violetta Iotzova ,  Peter Reczek

发明人： Violetta Iotzova ,  Peter Reczek

IPC分类号： A61K3119

CPC分类号： A61K31/19 ,  A61K31/203

摘要： Methods and compositions for treating various disorders by administering a therapeutically effective amount of a retinoic acid receptor antagonist alone or in combination or in conjunction with other therapeutic agents to promote angiogenesis are provided. Also provided are methods for obtaining additional retinoic acid receptor antagonists for use as therapeutic agents to promote angiogenesis.

摘要翻译： 提供了通过单独施用治疗有效量的视黄酸受体拮抗剂或与其它治疗剂组合或联合以促进血管生成来治疗各种疾病的方法和组合物。 还提供了获得用作促进血管生成的治疗剂的另外的视黄酸受体拮抗剂的方法。

公开(公告)号：US20060257404A1

公开(公告)日：2006-11-16

申请号：US11489829

申请日：2006-07-20

申请人： James Burke ,  Violetta Iotzova

发明人： James Burke ,  Violetta Iotzova

IPC分类号： A61K39/395 ,  G01N33/567 ,  C07K16/28

CPC分类号： G01N33/505

摘要： The present invention relates to modulators of P2Y10. Various modulators are disclosed, including an antibody that binds specifically to P2Y10. The present invention also relates to methods of activating resting T lymphocytes and inhibiting the proliferation of activated T lymphocytes. Methods of upregulating trascription of P2Y10 mRNA in a resting T lymphocyte, methods of inducing expression of P2Y10 on the surface of a resting T lymphocyte and methods of activating a T lymphocyte are disclosed. Also disclosed are pharmaceuticals and methods of treating an immune disease.

摘要翻译： 本发明涉及P2Y10的调节剂。 公开了各种调节剂，包括特异性结合P2Y10的抗体。 本发明还涉及激活静息T淋巴细胞并抑制活化的T淋巴细胞增殖的方法。 公开了在静息T淋巴细胞中上调P2Y10 mRNA的方法，在静息T淋巴细胞表面诱导P2Y10表达的方法和激活T淋巴细胞的方法。 还公开了治疗免疫疾病的药物和方法。

公开(公告)号：US07101962B2

公开(公告)日：2006-09-05

申请号：US10844736

申请日：2004-05-13

申请人： James R. Burke ,  Violetta Iotzova

发明人： James R. Burke ,  Violetta Iotzova

IPC分类号： A61K39/395

CPC分类号： G01N33/505

摘要： The present invention relates to modulators of P2Y10. Various modulators are disclosed, including an antibody that binds specifically to P2Y10. The present invention also relates to methods of activating resting T lymphocytes and inhibiting the proliferation of activated T lymphocytes. Methods of upregulating trascription of P2Y10 mRNA in a resting T lymphocyte, methods of inducing expression of P2Y10 on the surface of a resting T lymphocyte and methods of activating a T lymphocyte are disclosed. Also disclosed are pharmaceuticals and methods of treating an immune disease.

摘要翻译： 本发明涉及P2Y10的调节剂。 公开了各种调节剂，包括特异性结合P2Y10的抗体。 本发明还涉及激活静息T淋巴细胞并抑制活化的T淋巴细胞增殖的方法。 公开了在静息T淋巴细胞中上调P2Y10 mRNA的方法，在静息T淋巴细胞表面诱导P2Y10表达的方法和激活T淋巴细胞的方法。 还公开了治疗免疫疾病的药物和方法。