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    Modulators of the P2Y10 receptor useful in altering T lymphocyte function
    1.
    发明申请
    Modulators of the P2Y10 receptor useful in altering T lymphocyte function 审中-公开
    P2Y10受体的调节剂可用于改变T淋巴细胞功能

    公开(公告)号：US20060257404A1

    公开(公告)日：2006-11-16

    申请号：US11489829

    申请日：2006-07-20

    申请人： James Burke ,  Violetta Iotzova

    发明人： James Burke ,  Violetta Iotzova

    IPC分类号： A61K39/395 ,  G01N33/567 ,  C07K16/28

    CPC分类号： G01N33/505

    摘要： The present invention relates to modulators of P2Y10. Various modulators are disclosed, including an antibody that binds specifically to P2Y10. The present invention also relates to methods of activating resting T lymphocytes and inhibiting the proliferation of activated T lymphocytes. Methods of upregulating trascription of P2Y10 mRNA in a resting T lymphocyte, methods of inducing expression of P2Y10 on the surface of a resting T lymphocyte and methods of activating a T lymphocyte are disclosed. Also disclosed are pharmaceuticals and methods of treating an immune disease.

    摘要翻译： 本发明涉及P2Y10的调节剂。 公开了各种调节剂，包括特异性结合P2Y10的抗体。 本发明还涉及激活静息T淋巴细胞并抑制活化的T淋巴细胞增殖的方法。 公开了在静息T淋巴细胞中上调P2Y10 mRNA的方法，在静息T淋巴细胞表面诱导P2Y10表达的方法和激活T淋巴细胞的方法。 还公开了治疗免疫疾病的药物和方法。

    Supplementary energy starting system incorporating a timing circuit
    2.
    发明授权
    Supplementary energy starting system incorporating a timing circuit 有权
    补充能量启动系统并入定时电路

    公开(公告)号：US08820287B2

    公开(公告)日：2014-09-02

    申请号：US13400254

    申请日：2012-02-20

    申请人： Dean Solberg ,  James Burke

    发明人： Dean Solberg ,  James Burke

    IPC分类号： F02N11/08

    CPC分类号： F02N11/0866

    摘要： An engine cranking system and a method of cranking an engine are provided. The engine cranking system comprises an engine, cranking motor, and capacitor. The engine cranking system further comprises an electrical path interconnecting the cranking motor or a battery to the capacitor. The engine cranking system further comprises a control circuit coupled to the capacitor. The control circuit comprises a timer operative to track temporal information. The control circuit is operative to apply a control voltage that varies in response to the tracked temporal information. The control circuit further comprises a relay included in the electrical path. The relay is operative to switch, in response to the control voltage, between an open-circuit condition, in which the relay interrupts the electrical path, and a closed-circuit condition.

    摘要翻译： 提供一种发动机起动系统和起动发动机的方法。 发动机起动系统包括发动机，起动马达和电容器。 发动机起动系统还包括将起动马达或电池互连到电容器的电气路径。 发动机起动系统还包括耦合到电容器的控制电路。 控制电路包括用于跟踪时间信息的定时器。 控制电路可操作以施加响应于跟踪的时间信息而变化的控制电压。 控制电路还包括包含在电路径中的继电器。 继电器可操作以响应于控制电压在继电器中断电路径的开路状态与闭路状态之间切换。

    SUSTAINED RELEASE INTRAOCULAR IMPLANTS AND METHODS FOR PREVENTING RETINAL DYSFUNCTION
    4.
    发明申请
    SUSTAINED RELEASE INTRAOCULAR IMPLANTS AND METHODS FOR PREVENTING RETINAL DYSFUNCTION 有权
    可持续释放内镜植入物和预防后遗症的方法

    公开(公告)号：US20080131372A1

    公开(公告)日：2008-06-05

    申请号：US11927615

    申请日：2007-10-29

    申请人： Glenn T. Huang ,  James Burke ,  Patrick M. Hughes ,  Kai-Ming Zhang ,  Ton Lin ,  Larry A. Wheeler ,  Rosy Sheng Donn

    发明人： Glenn T. Huang ,  James Burke ,  Patrick M. Hughes ,  Kai-Ming Zhang ,  Ton Lin ,  Larry A. Wheeler ,  Rosy Sheng Donn

    IPC分类号： A61K31/498 ,  A61P27/16

    CPC分类号： A61K31/498 ,  A61K9/0051 ,  A61K47/34

    摘要： Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to prevent the occurrence of one or more ocular conditions, or to reduce one or more symptoms of an ocular condition, such as an ocular neurosensory disorder and the like.

    摘要翻译： 生物相容性眼内植入物包括α-2肾上腺素能受体激动剂和与α-2肾上腺素能受体激动剂相关的聚合物，以促进α-2肾上腺素能受体激动剂延长一段时间的眼睛释放。 α-2肾上腺素能受体激动剂可以与可生物降解的聚合物基质例如两种可生物降解的聚合物的基质相关联。 植入物可以放置在眼睛中以防止发生一种或多种眼部病症，或者减少眼部疾病如眼睛神经感觉障碍等的一种或多种症状。

    OCULAR THERAPY USING ALPHA-2 ADRENERGIC RECEPTOR ANTERIOR COMPOUNDS HAVING ENHANCED CLEARANCE RATES
    8.
    发明申请
    OCULAR THERAPY USING ALPHA-2 ADRENERGIC RECEPTOR ANTERIOR COMPOUNDS HAVING ENHANCED CLEARANCE RATES 审中-公开

    公开(公告)号：US20080112923A1

    公开(公告)日：2008-05-15

    申请号：US11949751

    申请日：2007-12-03

    申请人： Patrick HUGHES ,  James Burke ,  Joan-En Chang-Lin

    发明人： Patrick HUGHES ,  James Burke ,  Joan-En Chang-Lin

    IPC分类号： A61K31/765

    CPC分类号： A61K9/0051 ,  A61K9/0048 ,  A61K9/1647

    摘要： Ophthalmically therapeutic materials, such as liquid-containing compositions and polymeric drug delivery systems, include a therapeutic component which includes an alpha 2 adrenergic receptor agonist that is cleared from the anterior segment of an individual's eye to which the material is administered. The alpha 2 adrenergic receptor agonist may have a vitreal half-life greater than about three hours. The present materials are effective in treating an ocular condition(s) that affect the anterior segment of an eye, or the anterior and posterior segment of the eye. The materials are suitable for intravitreal or periocular administration and can provide prolonged drug delivery and therapeutic benefits to patients to which the materials have been administered. The alpha 2 adrenergic receptor agonists can be provided in liquid-containing formulations and/or bioerodible and/or non-bioerodible polymeric implants and microparticles. Methods of making and using the present materials are also described.

    ANTI-EXCITITOXIC SUSTAINED RELEASE INTRACULAR IMPLANTS AND RELATED METHODS
    9.
    发明申请
    ANTI-EXCITITOXIC SUSTAINED RELEASE INTRACULAR IMPLANTS AND RELATED METHODS 审中-公开
    抗真菌持续释放入侵植入物及相关方法

    公开(公告)号：US20070148208A1

    公开(公告)日：2007-06-28

    申请号：US11680615

    申请日：2007-02-28

    申请人： Patrick Hughes ,  James Burke ,  Rhett Schiffman

    发明人： Patrick Hughes ,  James Burke ,  Rhett Schiffman

    IPC分类号： A61F2/02 ,  A61K31/13

    CPC分类号： A61K9/0051

    摘要： Biocompatible intraocular implants include an anti-excitotoxic agent and a biodegradable polymer that is effective to facilitate release of the anti-excitotoxic agent into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as retinal damage, including glaucoma and proliferative vitreoretinopathy.

    摘要翻译： 生物相容性眼内植入物包括抗兴奋性毒性剂和可生物降解的聚合物，其有效促进抗兴奋性毒性剂长时间释放到眼睛中。 植入物的治疗剂可以与可生物降解的聚合物基质相关，例如基本上不含聚乙烯醇的基质。 植入物可以放置在眼睛中以治疗或减少一种或多种眼部病症的发生，例如视网膜损伤，包括青光眼和增生性玻璃体视网膜病变。