发明申请
US20070099962A1 5,6-Dihydropyrin-2-one compounds useful as inhibitors of thrombin
审中-公开
可用作凝血酶抑制剂的5,6-二氢吡啶-2-酮化合物
- 专利标题: 5,6-Dihydropyrin-2-one compounds useful as inhibitors of thrombin
- 专利标题(中): 可用作凝血酶抑制剂的5,6-二氢吡啶-2-酮化合物
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申请号: US10596506申请日: 2004-12-15
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公开(公告)号: US20070099962A1公开(公告)日: 2007-05-03
- 发明人: Kristina Berggren , Ojvind Davidsson , Ola Fjellstrom , David Gustafsson , Stephen Hanessian , Tord Inghardt , Mats Nagard , Ingemar Nilsson , Eric Therrien , Willem Van Otterlo
- 申请人: Kristina Berggren , Ojvind Davidsson , Ola Fjellstrom , David Gustafsson , Stephen Hanessian , Tord Inghardt , Mats Nagard , Ingemar Nilsson , Eric Therrien , Willem Van Otterlo
- 优先权: SE0303452-7 20031218; SE0401344-7 20040525
- 国际申请: PCT/SE04/01878 WO 20041215
- 主分类号: C07D401/02
- IPC分类号: C07D401/02 ; C07D213/63 ; C07D213/84 ; A61K31/4439 ; A61K31/4412
摘要:
There is provided a compound of formula (I) wherein R1, R2a, R2b, R3a, R3b, R4, R5, R6, A, G and L have meanings given in the description, which compounds are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as trombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is beneficial (e.g. conditions, such as thrombo-embolisms, where inhibition of trombin is required or desired, and/or conditions whereas anticoagulant therapy is indicated).
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