专利检索 ap:"Ojvind Davidsson" 第 1 页

1.

发明申请
Pyridin-2-one compounds useful as inhibitors of thrombin 审中-公开
标题翻译：可用作凝血酶抑制剂的吡啶-2-酮化合物

公开(公告)号：US20070161643A1

公开(公告)日：2007-07-12

申请号：US10597720

申请日：2005-02-02

申请人： Malken Bayrakdarian , Kristina Berggren , Ojvind Davidsson , Ola Fjellstrom , David Gustafsson , Stephen Hanessian , Tord Inghardt , Ingemar Nilsson , Mats Nagard , Daniel Simard , Eric Therrien

发明人： Malken Bayrakdarian , Kristina Berggren , Ojvind Davidsson , Ola Fjellstrom , David Gustafsson , Stephen Hanessian , Tord Inghardt , Ingemar Nilsson , Mats Nagard , Daniel Simard , Eric Therrien

IPC分类号： A61K31/513 , C07D487/02

CPC分类号： C07D413/12 , C07D211/98 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/12 , C07D417/14

摘要： There is provided a compound of formula I wherein the dashed line, R1, R2, R3a, R3b, A, D, E, G and L have meanings given in the description, which compounds are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is beneficial (e.g. conditions, such as thrombo-embolisms, where inhibition of thrombin is required or desired, and/or conditions where anticoagulant therapy is indicated).

摘要翻译： 提供式I化合物，其中虚线R 1，R 2，R 3，R 3，R 3， SUP，A，D，E，G和L具有在说明书中给出的含义，哪些化合物可用作或用作胰蛋白酶样蛋白酶的竞争性抑制剂例如凝血酶的前药，因此，特别地，在治疗凝血酶抑制有益的条件（例如需要或期望抑制凝血酶的条件，如血栓栓塞，和/或表示抗凝治疗的条件）。

2.

发明申请
5,6-Dihydropyrin-2-one compounds useful as inhibitors of thrombin 审中-公开
标题翻译：可用作凝血酶抑制剂的5,6-二氢吡啶-2-酮化合物

公开(公告)号：US20070099962A1

公开(公告)日：2007-05-03

申请号：US10596506

申请日：2004-12-15

申请人： Kristina Berggren , Ojvind Davidsson , Ola Fjellstrom , David Gustafsson , Stephen Hanessian , Tord Inghardt , Mats Nagard , Ingemar Nilsson , Eric Therrien , Willem Van Otterlo

发明人： Kristina Berggren , Ojvind Davidsson , Ola Fjellstrom , David Gustafsson , Stephen Hanessian , Tord Inghardt , Mats Nagard , Ingemar Nilsson , Eric Therrien , Willem Van Otterlo

IPC分类号： C07D401/02 , C07D213/63 , C07D213/84 , A61K31/4439 , A61K31/4412

CPC分类号： C07D211/98

摘要： There is provided a compound of formula (I) wherein R1, R2a, R2b, R3a, R3b, R4, R5, R6, A, G and L have meanings given in the description, which compounds are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as trombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is beneficial (e.g. conditions, such as thrombo-embolisms, where inhibition of trombin is required or desired, and/or conditions whereas anticoagulant therapy is indicated).

摘要翻译： 提供了式（I）的化合物，其中R 1，R 2，R 2，R 2b，R 3a， R 3b，R 4，R 5，R 6，A，G和L具有以下含义：描述，哪些化合物可用作或可用作胰蛋白酶样蛋白酶的竞争性抑制剂诸如凝血酶的前药，因此特别是在治疗凝血酶抑制有益的条件（例如条件，例如作为血栓栓塞，其中需要或期望凝血酶的抑制，和/或表示抗凝治疗的条件）。