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    1,5-Diaryl-pyrrole-3-carboxamide derivatives and their use as cannabinoid receptor modulators
    10.
    发明申请
    1,5-Diaryl-pyrrole-3-carboxamide derivatives and their use as cannabinoid receptor modulators 审中-公开

    公开(公告)号：US20060122230A1

    公开(公告)日：2006-06-08

    申请号：US10540276

    申请日：2003-12-18

    申请人： Anna Berggren ,  Stig Bosfrom ,  Leifeng Cheng ,  Stig Elebring ,  Peter Greasley ,  Mats Nagard ,  Johan Wilstermann ,  Emma Terricabras

    发明人： Anna Berggren ,  Stig Bosfrom ,  Leifeng Cheng ,  Stig Elebring ,  Peter Greasley ,  Mats Nagard ,  Johan Wilstermann ,  Emma Terricabras

    IPC分类号： A61K31/454 ,  A61K31/4015 ,  A61K31/401

    CPC分类号： C07D401/04 ,  A61K31/402 ,  A61K31/4025 ,  A61K31/454 ,  C07D207/34 ,  C07D401/06

    摘要： The present invention relates to a compound of formula (I) in which R1 and R2 independently represent phenyl, thienyl or pyridyl each of which is optionally substituted by one, two or three groups represented by Z; and R3 is H, a C1-3alkyl group, a C1-3alkoxymethyl group, trifluoromethyl, a hydroxyC1-3alkyl group, an aminoC1-3alkyl group, C1-3alkoxycarbonyl, carboxy, cyano, carbamoyl, mono or di C1-3alkylcarbamoyl, acetyl, or hydrazinocarbonyl of formula —CONHNRaRb wherein Ra and Rb are as defined for R4 and R5 respectively; X is CO or SO2; Y is absent or represents NH optionally substituted by a C1-3alkyl group; R4 and R5 independently represent: a C1-6alkyl group; an (amino)C1-4alkyl-group in which the amino is optionally substituted by one or more C1-3alkyl groups; an optionally substituted non-aromatic C3-15carbocyclic group; a (C3-12cycloalkyl)C1-3alkyl-group; a group —(CH2)r(phenyl)s; naphthyl; anthracenyl; a saturated 5 to 8 membered heterocyclic group containing one nitrogen and optionally one of the following: oxygen, sulphur or an additional nitrogen wherein the heterocyclic group is optionally substituted; 1-adamantylmethyl; a group —(CH2)t Het where Het represents an aromatic heterocycle optionally substituted; or R4 represents H and R5 is as defined above; or R4 and R5 together with the nitrogen atom to which they are attached represent a saturated 5 to 8 membered heterocyclic group; R6 is H, a C1-3alkyl group, a C1-3alkoxymethyl group, trifluoromethyl, a hydroxyC1-3alkyl group, C1-3alkoxycarbonyl, carboxy, cyano, carbamoyl, mono or di C1-3alkylcarbamoyl, acetyl, or hydrazinocarbonyl of formula —CONHNRaRb; with provisos; to processes for preparing such compounds, to their use in the treatment of obesity, psychiatric and neurological disorders particularly obesity, to methods for their therapeutic use and to pharmaceutical compositions containing them.