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22 条记录 (耗时 0.039 秒)

    Compounds 148
    4.
    发明授权
    Compounds 148 失效
    化合物148

    公开(公告)号：US08119673B2

    公开(公告)日：2012-02-21

    申请号：US12489458

    申请日：2009-06-23

    申请人： Jonas Brånalt ,  David Gustafsson ,  Ingemar Nilsson ,  Magnus Polla

    发明人： Jonas Brånalt ,  David Gustafsson ,  Ingemar Nilsson ,  Magnus Polla

    IPC分类号： A61K31/41 ,  C07D257/04

    CPC分类号： C07D403/12 ,  C07D405/14 ,  C07D413/12

    摘要： This invention relates to novel pharmaceutically useful compounds of formula (I), in particular compounds that are competitive inhibitors of trypsin-like serine proteases, especially thrombin, their use as medicaments, pharmaceutical compositions containing them and synthetic routes to their production.

    摘要翻译： 本发明涉及新的药学上有用的式（I）化合物，特别是作为胰蛋白酶样丝氨酸蛋白酶，特别是凝血酶的竞争性抑制剂，它们作为药物的药物，含有它们的药物组合物和其生产合成途径的化合物。

    Combinations comprising a low molecular weight thrombin inhibitor and a prodrug of a low molecular weight thrombin inhibitor
    7.
    发明申请
    Combinations comprising a low molecular weight thrombin inhibitor and a prodrug of a low molecular weight thrombin inhibitor 审中-公开
    包含低分子量凝血酶抑制剂和低分子量凝血酶抑制剂的前药的组合

    公开(公告)号：US20080113960A1

    公开(公告)日：2008-05-15

    申请号：US11979882

    申请日：2007-11-09

    申请人： David Gustafsson

    发明人： David Gustafsson

    IPC分类号： A61K31/397

    CPC分类号： A61K31/197 ,  A61K2300/00

    摘要： According to the invention there is provided a kit of parts comprising: (a) a pharmaceutical formulation including a low molecular weight thrombin inhibitor, or a pharmaceutically acceptable derivative thereof, in admixture with a pharmaceutically acceptable adjuvant, diluent or carrier; and (b) a pharmaceutical formulation including a prodrug of a low molecular weight thrombin inhibitor, or a pharmaceutically acceptable derivative of that prodrug, in admixture with a pharmaceutically acceptable adjuvant, diluent or carrier, which components (a) and (b) are each provided in a form that is suitable for administration in conjunction with the other, as well as the use of such a kit of parts in the treatment of a condition in which inhibition of thrombin is required or desired.

    摘要翻译： 根据本发明，提供了一种试剂盒，其包含：（a）包含低分子量凝血酶抑制剂或其药学上可接受的衍生物的药物制剂，其与药学上可接受的佐剂，稀释剂或载体的混合物; 和（b）药物制剂，其包含低分子量凝血酶抑制剂的前药或该前药的药学上可接受的衍生物与药学上可接受的佐剂，稀释剂或载体的混合物，组分（a）和（b）各自 以适于与另一种联合施用的形式提供，以及在治疗需要或期望的凝血酶抑制的病症中使用这种试剂盒。

    Amino acid derivatives
    8.
    发明授权
    Amino acid derivatives 失效
    氨基酸衍生物

    公开(公告)号：US06617320B2

    公开(公告)日：2003-09-09

    申请号：US09995564

    申请日：2001-11-29

    申请人： David Gustafsson ,  Jan-Erik Nyström

    发明人： David Gustafsson ,  Jan-Erik Nyström

    IPC分类号： A61K31397

    CPC分类号： C07D211/60 ,  C07D205/04 ,  C07D207/16

    摘要： There is provided amino acid derivatives of formula I, wherein p, q, R1, R2, R3, R4, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as hirombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

    摘要翻译： 提供式I的氨基酸衍生物，其中p，q，R 1，R 2，R 3，R 4，Y，n和B具有在描述中给出的含义，其可用作胰蛋白酶样蛋白酶的竞争性抑制剂，例如hirombin， 特别是在需要抑制凝血酶（例如血栓形成）或作为抗凝剂的条件的治疗中。

    Wideband and Reconfigurable Doherty Based Amplifier
    9.
    发明申请
    Wideband and Reconfigurable Doherty Based Amplifier 有权
    宽带和可重新配置的基于多基因的放大器

    公开(公告)号：US20140035682A1

    公开(公告)日：2014-02-06

    申请号：US14009163

    申请日：2011-05-05

    申请人： David Gustafsson ,  Christian Fager

    发明人： David Gustafsson ,  Christian Fager

    IPC分类号： H03F1/02

    CPC分类号： H03F1/0288

    摘要： The present disclosure provides a power amplifier comprising a main amplifier and an auxiliary amplifier. The power amplifier is configured to deliver an output power Pout. A First Efficiency Peak (FEP) is defined as a first efficiency peak in the power ratio Pout to Poutmax. Poutmax is a maximum power output of the power amplifier and PFEP defines a power ratio at the FEP. The main amplifier is configured to be biased by a main amplifier bias Vds,m that is substantially equal to an auxiliary amplifier bias Vds,a times xb with xb being a main amplifier output current in relation to the maximum current through the main amplifier when Pout equals PFEP. The impedances of a load and a main amplifier transmission line are arranged to be substantially equal. A corresponding method and a node in a wireless communication system comprising the power amplifier are also disclosed.

    摘要翻译： 本公开提供了一种功率放大器，包括主放大器和辅助放大器。 功率放大器被配置为传送输出功率Pout。 第一效率峰值（FEP）被定义为功率比Pout至Poutmax中的第一效率峰值。 Poutmax是功率放大器的最大功率输出，PFEP定义了FEP的功率比。 主放大器被配置为被主放大器偏置Vds，m基本上等于辅助放大器偏置Vds，一倍xb，其中xb是主放大器输出电流，相对于通过主放大器的最大电流，Pout 等于PFEP。 负载和主放大器传输线的阻抗被布置为基本相等。 还公开了包括功率放大器的无线通信系统中的相应方法和节点。

    Method for retrieving the implemented data model from a device
    10.
    发明授权
    Method for retrieving the implemented data model from a device 有权
    从设备中检索实现的数据模型的方法

    公开(公告)号：US08874714B2

    公开(公告)日：2014-10-28

    申请号：US13085581

    申请日：2011-04-13

    申请人： Magnus Ljung ,  David Möllersten ,  David Gustafsson

    发明人： Magnus Ljung ,  David Möllersten ,  David Gustafsson

    IPC分类号： G06F15/177 ,  H04L12/24

    CPC分类号： H04L41/145 ,  H04L41/0213 ,  H04L41/0859

    摘要： Presented is an apparatus and methods for collecting the implemented data model and version information from an end user device. The apparatus is communicatively connected to the end user device and uses, for example, the Broadband Forum TR-069 protocol or another protocol for communications. The method interrogates the end user device to determine all parameters and their data types by traversing the end user device's data model level by level and instantiating any objects discovered that are instantiable but not yet instantiated. The method archives the data model and end user device version information for later use with like devices.

    摘要翻译： 提出了一种用于从最终用户设备收集实现的数据模型和版本信息的装置和方法。 该设备通信地连接到终端用户设备，并且使用例如宽带论坛TR-069协议或用于通信的另一协议。 该方法通过逐级遍历最终用户设备的数据模型并实例化发现的可实例化但尚未实例化的任何对象来询问最终用户设备来确定所有参数及其数据类型。 该方法归档数据模型和最终用户设备版本信息，以供以后与类似设备一起使用。