发明申请
US20070124826A1 Method of differentiation from embryo-stem cell of primate to hematogenous cell
审中-公开
从灵长类动物胚胎干细胞分化为造血细胞的方法
- 专利标题: Method of differentiation from embryo-stem cell of primate to hematogenous cell
- 专利标题(中): 从灵长类动物胚胎干细胞分化为造血细胞的方法
-
申请号: US10568502申请日: 2004-08-24
-
公开(公告)号: US20070124826A1公开(公告)日: 2007-05-31
- 发明人: Yutaka Hanazono , Kyoko Sasaki
- 申请人: Yutaka Hanazono , Kyoko Sasaki
- 申请人地址: JP OSAKA 541-8505
- 专利权人: TANABE SEIYAKU CO., LTD.
- 当前专利权人: TANABE SEIYAKU CO., LTD.
- 当前专利权人地址: JP OSAKA 541-8505
- 优先权: JP2003-208724 20030825
- 国际申请: PCT/JP04/12456 WO 20040824
- 主分类号: A01K67/027
- IPC分类号: A01K67/027 ; C12N5/08
摘要:
A method of differentiation from an embryonic stem cell of a primate into a hematopoietic cell, comprising maintaining an embryonic stem cell of a primate under conditions suitable for induction of differentiation into a hematopoietic cell, transplanting the resulting cell into a fetus in a uterus of a pregnant sheep, rearing the fetus, administering a cytokine specific for a primate to a born lamb, and obtaining a hematopoietic cell of a primate from a sheep obtained by rearing the lamb, a method for producing a hematopoietic cell of a primate, a hematopoietic cell obtained by the method, and a method for producing a chimeric sheep which produces a hematopoietic cell of a primate, comprising maintaining an embryonic stem cell of a primate under conditions suitable for induction of differentiation into a hematopoietic cell, and transplanting the resulting cell into a fetus in a uterus of a pregnant sheep. According to the present invention, it becomes possible to develop a means for treating a disease or a condition requiring construction of a hematopoietic system or an action of a hematopoietic cell.