A multi metal base thermal resistance alloy and a mold with the multi metal base thermal resistance alloy layer are provided. The weight percent of each element in this alloy is less than 45%. The structure of the alloy is an amorphous structure and the phonon thermal conductivity of the amorphous structure is intrinsically low. Therefore, the alloy is a metal material with low thermal conductivity coefficient and high thermal stability, which can increase the heat retaining property of the die casting mold, enhance the forming yield and stability of a metal sheet with a low fusion point, and is suitable to be used as a thermal-resistance coating material on die casting molds.