发明申请
- 专利标题： Nerve Cell Differentiation Inducer
- 专利标题（中）： 神经细胞分化诱导剂
-
申请号： US10588290申请日： 2005-02-04
-
公开(公告)号： US20070219150A1公开(公告)日： 2007-09-20
- 发明人: Toshihiro Nakajima , Satoshi Yamasaki , Naoko Yagishita , Daijuro Tonaki , Yukihiro Kato
- 申请人： Toshihiro Nakajima , Satoshi Yamasaki , Naoko Yagishita , Daijuro Tonaki , Yukihiro Kato
- 申请人地址： JP Kanagawa 2300046
- 专利权人： Locomogene, Inc.
- 当前专利权人： Locomogene, Inc.
- 当前专利权人地址： JP Kanagawa 2300046
- 优先权： JP2004-031320 20040206
- 国际申请： PCT/JP05/02106 WO 20050204
- 主分类号： A61K31/7052
- IPC分类号： A61K31/7052 ; C12N5/00
摘要：
The present invention provides a nerve cell differentiation inducing drug containing a Synoviolin expression inhibitor which is a useful drug for treatments of neural disorders, particularly Alzheimer's disease, Parkinson's disease, peripheral nerve disorders or spinal injury. As Synoviolin expression inhibitors, there are siRNA against gene coding Synoviolin (SEQ ID No. 1 or 2), or shRNA, a decoy nucleic acid that inhibits the promoter activity by binding to the transcription factor of the promoter of the Synoviolin gene or antisense oligonucleotide against gene coding the Synoviolin. The nerve cell differentiation inducing drug of the present invention is used for the treatment of neural disorders including Alzheimer's disease, Parkinson's disease, peripheral nerve disorders or spinal injury.
信息查询
