公开(公告)号：US20070219150A1

公开(公告)日：2007-09-20

申请号：US10588290

申请日：2005-02-04

申请人： Toshihiro Nakajima ,  Satoshi Yamasaki ,  Naoko Yagishita ,  Daijuro Tonaki ,  Yukihiro Kato

发明人： Toshihiro Nakajima ,  Satoshi Yamasaki ,  Naoko Yagishita ,  Daijuro Tonaki ,  Yukihiro Kato

IPC分类号： A61K31/7052 ,  C12N5/00

CPC分类号： A61K31/7088

摘要： The present invention provides a nerve cell differentiation inducing drug containing a Synoviolin expression inhibitor which is a useful drug for treatments of neural disorders, particularly Alzheimer's disease, Parkinson's disease, peripheral nerve disorders or spinal injury. As Synoviolin expression inhibitors, there are siRNA against gene coding Synoviolin (SEQ ID No. 1 or 2), or shRNA, a decoy nucleic acid that inhibits the promoter activity by binding to the transcription factor of the promoter of the Synoviolin gene or antisense oligonucleotide against gene coding the Synoviolin. The nerve cell differentiation inducing drug of the present invention is used for the treatment of neural disorders including Alzheimer's disease, Parkinson's disease, peripheral nerve disorders or spinal injury.

摘要翻译： 本发明提供了含有滑膜素表达抑制剂的神经细胞分化诱导药物，其是治疗神经障碍，特别是阿尔茨海默氏病，帕金森病，周围神经障碍或脊髓损伤的有用药物。 作为滑膜素表达抑制剂，存在针对基因编码滑膜蛋白（SEQ ID No.1或2）的siRNA或shRNA，通过与滑膜炎基因或反义寡核苷酸启动子的转录因子结合来抑制启动子活性的诱饵核酸 针对基因编码Synoviolin。 本发明的神经细胞分化诱导药物用于治疗包括阿尔茨海默氏病，帕金森氏病，周围神经障碍或脊髓损伤的神经障碍。