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公开(公告)号：US20070219150A1
公开(公告)日：2007-09-20
申请号：US10588290
申请日：2005-02-04
IPC分类号： A61K31/7052 , C12N5/00
CPC分类号： A61K31/7088
摘要： The present invention provides a nerve cell differentiation inducing drug containing a Synoviolin expression inhibitor which is a useful drug for treatments of neural disorders, particularly Alzheimer's disease, Parkinson's disease, peripheral nerve disorders or spinal injury. As Synoviolin expression inhibitors, there are siRNA against gene coding Synoviolin (SEQ ID No. 1 or 2), or shRNA, a decoy nucleic acid that inhibits the promoter activity by binding to the transcription factor of the promoter of the Synoviolin gene or antisense oligonucleotide against gene coding the Synoviolin. The nerve cell differentiation inducing drug of the present invention is used for the treatment of neural disorders including Alzheimer's disease, Parkinson's disease, peripheral nerve disorders or spinal injury.
摘要翻译： 本发明提供了含有滑膜素表达抑制剂的神经细胞分化诱导药物，其是治疗神经障碍，特别是阿尔茨海默氏病，帕金森病，周围神经障碍或脊髓损伤的有用药物。 作为滑膜素表达抑制剂，存在针对基因编码滑膜蛋白（SEQ ID No.1或2）的siRNA或shRNA，通过与滑膜炎基因或反义寡核苷酸启动子的转录因子结合来抑制启动子活性的诱饵核酸 针对基因编码Synoviolin。 本发明的神经细胞分化诱导药物用于治疗包括阿尔茨海默氏病，帕金森氏病，周围神经障碍或脊髓损伤的神经障碍。
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公开(公告)号：US20090029929A1
公开(公告)日：2009-01-29
申请号：US10594146
申请日：2005-03-28
申请人： Toshihiro Nakajima , Kaneyuki Tsuchimochi , Naoko Yagishita , Satoshi Yamasaki , Yukihiro Kato , Tetsuya Amano , Kaori Tamitsu
发明人： Toshihiro Nakajima , Kaneyuki Tsuchimochi , Naoko Yagishita , Satoshi Yamasaki , Yukihiro Kato , Tetsuya Amano , Kaori Tamitsu
IPC分类号： A61K31/711 , A61K48/00 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/00 , C12N15/12 , C12N5/10
CPC分类号： C12N15/113 , A61K31/7088 , A61K48/00 , C12N2310/13
摘要： The present invention provides a decoy nucleic acid for the Synoviolin gene promoter. Also provided is the decoy nucleic acid can inhibit the promoter activity by binding to the transcription factor of the Synoviolin gene promoter. It also provides a decoy nucleic acid as expressed in (a) a decoy nucleic acid consisting of a nucleotide sequence as shown in SEQ ID NO: 11 or 12; and it also provides (b) a decoy nucleic acid consisting of a nucleotide sequence as shown in SEQ ID NO: 11 or 12 having deletion, substitution or addition of one or several nucleotides and has the function of inhibiting Synoviolin gene promoter activity.
摘要翻译： 本发明提供了用于滑膜炎基因启动子的诱饵核酸。 还提供了诱饵核酸可以通过与滑膜素基因启动子的转录因子结合来抑制启动子活性。 它还提供如（a）由如SEQ ID NO：11或12所示的核苷酸序列组成的诱饵核酸所表达的诱饵核酸; 并且还提供（b）由SEQ ID NO：11或12所示的具有缺失，取代或添加一个或几个核苷酸的核苷酸序列组成的具有抑制滑膜素基因启动子活性的功能的诱饵核酸。
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公开(公告)号：US20070238677A1
公开(公告)日：2007-10-11
申请号：US10592918
申请日：2005-03-16
申请人： Toshihiro Nakajima , Tetsuya Amano , Satoshi Yamasaki , Naoko Yagishita , Takeshi Sasaki , Yukihiro Kato , Lei Zhang
发明人： Toshihiro Nakajima , Tetsuya Amano , Satoshi Yamasaki , Naoko Yagishita , Takeshi Sasaki , Yukihiro Kato , Lei Zhang
IPC分类号： A61K31/7088 , A61K45/00 , A61K48/00 , A61P19/02 , A61P29/00 , A61P35/00 , C12N15/09 , C12N5/00
CPC分类号： C12N15/113 , A61K48/00 , C12N2310/14
摘要： The present invention provides a pharmaceutical composition containing a substance which inhibits the proliferation of synovial tissue or synovial cells and the interleukin-6 production. It also provides a pharmaceutical composition for inhibiting the proliferation of synovial tissue or synovial cells and the interleukin-6 production, which is useful for diagnosing and treating at least one selected from the group consisting of rheumatoid arthritis, fibrosis, arthritis, cancers, and cerebral neural diseases. In addition, it provides a method for inhibiting the proliferation of synovial cells and the interleukin-6 production by inhibiting the expression of hsHRD3 in synovial cells.
摘要翻译： 本发明提供含有抑制滑膜组织或滑膜细胞增殖的物质和白细胞介素-6产生的药物组合物。 它还提供用于抑制滑膜组织或滑膜细胞增殖的药物组合物和白细胞介素-6产生，其可用于诊断和治疗选自以下的至少一种：类风湿性关节炎，纤维化，关节炎，癌症和脑 神经疾病 另外，通过抑制滑膜细胞中hsHRD3的表达，提供了抑制滑膜细胞增殖和白细胞介素-6产生的方法。
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公开(公告)号：US20080274479A1
公开(公告)日：2008-11-06
申请号：US11628412
申请日：2005-06-02
申请人： Toshihiro Nakajima , Sayumi Toriyama , Tadayuki Yamadera , Tomohiko Ohta , Satoshi Yamasaki , Naoko Yagishita , Lei Zhang , Rie Ikeda , Takeshi Sasaki , Tetsuya Amano
发明人： Toshihiro Nakajima , Sayumi Toriyama , Tadayuki Yamadera , Tomohiko Ohta , Satoshi Yamasaki , Naoko Yagishita , Lei Zhang , Rie Ikeda , Takeshi Sasaki , Tetsuya Amano
IPC分类号： G01N33/53
CPC分类号： C12Q1/25 , G01N2333/9015 , G01N2500/02
摘要： The present invention relates to an assay method for determining a auto-ubiquitination activity of synoviolin, comprising reacting synoviolin and ubiquitin in a reaction system containing them and determining an amount of ubiquitin binding to synoviolin, to a method of screening a substance capable of regulating such an activity, and to a kit for auto-ubiquitination assay of synoviolin.
摘要翻译： 本发明涉及一种用于测定滑膜蛋白的自身泛素化活性的测定方法，包括使滑膜蛋白和泛素在含有它们的反应体系中反应并确定与滑膜蛋白结合的泛素的量，以筛选能够调节这种蛋白质的物质的方法 一种活性，以及用于滑膜蛋白自动泛素化测定的试剂盒。
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公开(公告)号：US20080039409A1
公开(公告)日：2008-02-14
申请号：US10584289
申请日：2004-12-24
IPC分类号： A61K31/7105 , A61P35/00 , C12N5/06 , C12N9/12
CPC分类号： C07K14/705 , A01K67/0276 , A01K2217/075 , A01K2267/0325 , A01K2267/0331 , A61K31/7088 , C12N15/8509
摘要： The present invention provides a method for suppressing cancer comprising activating tumor suppressor gene p53 or protein p53 for localizing the protein to the nuclear, and a pharmaceutical composition comprising a substance that promotes activation of tumor suppressor gene p53 or protein p53.
摘要翻译： 本发明提供一种抑制癌症的方法，包括激活肿瘤抑制基因p53或蛋白质p53以将蛋白定位于核，以及包含促进肿瘤抑制基因p53或蛋白质p53激活的物质的药物组合物。
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公开(公告)号：US20070275887A1
公开(公告)日：2007-11-29
申请号：US10576281
申请日：2004-10-20
申请人： Toshihiro Nakajima , Tetsuya Amano , Lei Zhang , Rie Ikeda , Satoshi Yamasaki , Naoko Yagishita
发明人： Toshihiro Nakajima , Tetsuya Amano , Lei Zhang , Rie Ikeda , Satoshi Yamasaki , Naoko Yagishita
CPC分类号： C12N15/1137 , A61K31/7088 , A61K45/06 , C12N2310/14 , A61K2300/00
摘要： The present invention provides a method for inhibiting secretase activity. A method for promoting the sensitivity of a secretase inhibitor, a method for binding synoviolin to Herp (homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-like domain member 1), or the like is employed to inhibit secretase activity.
摘要翻译： 本发明提供抑制分泌酶活性的方法。 用于促进分泌酶抑制剂的敏感性的方法，将滑膜蛋白与Herp结合的方法（同型半胱氨酸诱导型内质网应激诱导型泛素样结构域成员1）等用于抑制分泌酶活性。
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公开(公告)号：US20070134720A1
公开(公告)日：2007-06-14
申请号：US10568913
申请日：2004-08-20
申请人： Toshihiro Nakajima , Tetsuya Amano , Lei Zhang , Rie Ikeda , Satoshi Yamasaki , Naoko Yagishita , Hiromitsu Yokohama , Motoji Kogushi
发明人： Toshihiro Nakajima , Tetsuya Amano , Lei Zhang , Rie Ikeda , Satoshi Yamasaki , Naoko Yagishita , Hiromitsu Yokohama , Motoji Kogushi
CPC分类号： A61K38/16 , A61K38/005 , C12Q1/25 , C12Q1/26 , G01N2333/90245 , G01N2500/00
摘要： The present invention provides methods for evaluating the regulation on prolyl 4-hydroxylase activity. The present invention also provides screening methods using the evaluation methods. Furthermore, the present invention provides methods of screening for compounds that are useful for treating or preventing fibrosis or rheumatoid arthritis. The present invention relates to methods for detecting regulatory activity on the synoviolin ubiquitination of prolyl 4-hydroxylase α subunit (P4HA1). It also relates to methods of screening for compounds with regulatory effect on the ubiquitination activity of synoviolin on P4HA1 based on these methods. Compounds discovered in the screening are useful for treating and/or preventing diseases caused by abnormalities in the prolyl 4-hydroxylase activity, such as fibrosis and rheumatoid arthritis.
摘要翻译： 本发明提供了评估脯氨酰4-羟化酶活性调节的方法。 本发明还提供了使用评价方法的筛选方法。 此外，本发明提供筛选可用于治疗或预防纤维化或类风湿性关节炎的化合物的方法。 本发明涉及检测脯氨酰4-羟化酶α亚基（P4HA1）的滑膜蛋白泛素化的调节活性的方法。 它还涉及基于这些方法筛选对P4HA1上滑膜素泛素化活性具有调节作用的化合物的方法。 在筛选中发现的化合物可用于治疗和/或预防由脯氨酰4-羟化酶活性异常引起的疾病，例如纤维化和类风湿性关节炎。
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公开(公告)号：US20080070298A1
公开(公告)日：2008-03-20
申请号：US10569330
申请日：2004-08-23
CPC分类号： C07K14/47
摘要： The present invention provides a promoter of the synoviolin gene comprising at least the nucleotide sequence of nucleotides 2120-2130 in the nucleotide sequence represented by SEQ ID: NO 1 or 2, or comprising at least the nucleotide sequence of the region of nucleotides 1-2201, 969-2201, 1142-2201, 1699-2201, 1880-2201, 2002-2201, 2094-2201 or 2118-2201 in the nucleotide sequence represented by SEQ ID: NO 1 or 2;or a method for regulating transcription activity characterized in that the activity of the promoter is inhibited or enhanced.
摘要翻译： 本发明提供滑膜蛋白基因的启动子，其至少包含由SEQ ID NO：1所示的核苷酸序列中的核苷酸2120-2130的核苷酸序列，或者至少包含核苷酸区域的核苷酸序列1-2201 ，969-2201,1142-2201,1699-2201,1880-2201,2002-2201,2094-2201或2118-2201所示的核苷酸序列;或调节转录活性的方法，其特征在于 因为启动子的活性被抑制或增强。
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公开(公告)号：US20070244060A1
公开(公告)日：2007-10-18
申请号：US10568823
申请日：2004-08-23
IPC分类号： A61K31/7105 , A61K31/343
CPC分类号： A61K31/00 , A61K31/335 , A61K31/343 , A61K31/7072 , A61K31/7105
摘要： The present invention provides an apoptosis-inducing agent or a therapeutic agent for autoimmune diseases, comprising a substance that induces ER stress; and a method for inhibiting the proliferation of cells, wherein the cells (for example, synoviocytes) are treated with the inducing agent.
摘要翻译： 本发明提供一种凋亡诱导剂或用于自身免疫疾病的治疗剂，其包含诱导ER应激的物质; 以及抑制细胞增殖的方法，其中用诱导剂处理细胞（例如滑膜细胞）。
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公开(公告)号：US20080305499A1
公开(公告)日：2008-12-11
申请号：US11631283
申请日：2005-07-04
申请人： Toshihiro Nakajima , Satoshi Yamasaki , Lei Zhang , Tetsuya Amano
发明人： Toshihiro Nakajima , Satoshi Yamasaki , Lei Zhang , Tetsuya Amano
IPC分类号： G01N33/567 , C07K16/40 , C12N5/16 , C12P21/08 , C12N9/10
CPC分类号： C12Q1/25 , A61K2039/505 , C07K16/40 , C07K2317/76
摘要： The present invention relates to an antibody against synoviolin or a fragment thereof for providing a monoclonal antibody capable of recognizing a part of synoviolin, which monoclonal antibody is capable of inhibiting the auto-ubiquitination of synoviolin.
摘要翻译： 本发明涉及用于提供能够识别部分滑膜蛋白的单克隆抗体的抗滑膜炎抗体或其片段，该单克隆抗体能够抑制滑膜素的自身泛素化。
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