发明申请
US20070253900A1 Nucleic acid and corresponding protein entitled 98P4B6 useful in treatment and detection of cancer
有权
核酸和相应的蛋白质98P4B6可用于治疗和检测癌症
- 专利标题： Nucleic acid and corresponding protein entitled 98P4B6 useful in treatment and detection of cancer
- 专利标题（中）： 核酸和相应的蛋白质98P4B6可用于治疗和检测癌症
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申请号： US11588203申请日： 2006-10-25
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公开(公告)号： US20070253900A1公开(公告)日： 2007-11-01
- 发明人: Arthur Raitano , Wangmao Ge , Aya Jakobovits , Pia Challita-Eid , Mary Faris
- 申请人： Arthur Raitano , Wangmao Ge , Aya Jakobovits , Pia Challita-Eid , Mary Faris
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A01K67/00 ; A61K31/395 ; A61K39/00 ; A61K49/00 ; A61K51/10 ; C07H21/04 ; C07K7/00 ; C12Q1/68 ; G01N33/574 ; G01N33/567 ; G01N33/53 ; C12N5/12 ; C07K14/00 ; C07H21/02 ; A61K49/16 ; A61K39/44 ; A61K31/7088 ; A61K35/12
摘要：
A novel gene 098P4B6 (also designated STEAP-2) and its encoded protein, and variants thereof, are described wherein 98P4B6 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table 1. Consequently, 98P4B6 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 98P4B6 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 98P4B6 can be used in active or passive immunization.