发明申请
US20070259806A1 Brain-Associated Inhibitor of Tissue-Type Plasminogen Activator
审中-公开
脑组织型纤溶酶原激活物的脑相关抑制剂
- 专利标题： Brain-Associated Inhibitor of Tissue-Type Plasminogen Activator
- 专利标题（中）： 脑组织型纤溶酶原激活物的脑相关抑制剂
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申请号： US11757481申请日： 2007-06-04
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公开(公告)号： US20070259806A1公开(公告)日： 2007-11-08
- 发明人: Gregg Hastings , Timothy Coleman , Patrick Dillon , Daniel Lawrence , Maria Sandkvist , Manuel Yepes , Michael Wong
- 申请人： Gregg Hastings , Timothy Coleman , Patrick Dillon , Daniel Lawrence , Maria Sandkvist , Manuel Yepes , Michael Wong
- 申请人地址： US MD Rockville US MI Ann Arbor
- 专利权人： Human Genome Sciences, Inc.,The Regents of the University of Michigan
- 当前专利权人： Human Genome Sciences, Inc.,The Regents of the University of Michigan
- 当前专利权人地址： US MD Rockville US MI Ann Arbor
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07H21/04 ; C07K14/00 ; C07K16/18 ; C12N15/00 ; C12N15/87 ; C12N5/06 ; C12P1/04 ; G01N33/53
摘要：
The present invention relates to a novel BAIT protein which is a member of serpin superfamily which is expressed primarily in brain tissue. In particular, isolated nucleic acid molecules are provided encoding the human and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of BAIT activity. Also provided are diagnostic methods for detecting nervous system-related disorders and therapeutic methods for treating nervous system-related disorders. Additionally, the present invention is related to methods of treating patients with BAIT polynucleotides or polypeptides, wherein said patients have had seizures or epilepsy.
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