摘要:
The present invention relates to a novel BAIT protein which is a member of serpin superfamily which is expressed primarily in brain tissue. In particular, isolated nucleic acid molecules are provided encoding the human and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of BAIT activity. Also provided are diagnostic methods for detecting nervous system-related disorders and therapeutic methods for treating nervous system-related disorders. Additionally, the present invention is related to methods of treating patients with BAIT polynucleotides or polypeptides, wherein said patients have had seizures or epilepsy.
摘要:
Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the PDGF signaling pathway. The inventive method and composition is particularly suitable for conjunctive therapy of ischemic stroke using tPA and an anti-PDGF-C antagonist or an anti-PDGFR-α antagonist.
摘要:
Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the PDGF signaling pathway. The inventive method and composition is particularly suitable for conjunctive therapy of ischemic stroke using tPA and an anti-PDGF-C antagonist or an anti-PDGFR-α antagonist.
摘要:
Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the PDGF signaling pathway. The inventive method and composition is particularly suitable for conjunctive therapy of ischemic stroke using tPA and an anti-PDGF-C antagonist or an anti-PDGFR-α antagonist.
摘要:
Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the PDGF signaling pathway. The inventive method and composition is particularly suitable for conjunctive therapy of ischemic stroke using tPA and an anti-PDGF-C antagonist or an anti-PDGFR-α antagonist.
摘要:
The present invention is a method of reducing vascular permeability in tissue of a subject comprising inhibiting the activity of serine proteinase tissue-type plasminogen activator (tPA). This tPA activity which increases permeability of the tissue in a subject results in edema in the tissue is separate from tPA's thrombolytic activity. The present invention more specifically relates to administering an amount of a tPA inhibitor sufficient to reduce the vascular permeability increasing activity of tPA in a subject. Useful tPA inhibitors for the present method are neuroserpin, mutant neuroserpin, wild-type PAI-1, mutant PAI-1, an antibody that binds to tPA, an antibody that binds to the low-density lipoprotein (LDL) receptor or a low-density lipoprotein (LDL) receptor family antagonist.
摘要:
An RFID system including a battery powered RFID reader configured to detect an RFID tag. The RFID reader include a mounting surface configured to be affixed relative to an external structure, and is capable of being wirelessly coupled to a receiver for transmitting data to the receiver.
摘要:
An RFID system and network including an RFID reader capable of detecting an RFID tag. The RFID system further includes an intermediate device configured to be wirelessly coupled to the RFID reader. A third device is configured to be coupled to the intermediate device for communicating with the RFID reader via the intermediate device.
摘要:
An RFID antenna or tag is designed to be integrated with artwork such as a logo, brand name, trademark, graphic element, and/or letters. The RFID tag comprises a substrate, which may include or be integrated with a product package. An antenna is formed on the substrate. Non-conductive artwork is printed on the substrate. The antenna includes first and second conductive traces that are integrated with artwork. An integrated circuit is connected across the first and second conductive traces. The conductive traces are integrated with the artwork that is printed on or otherwise integrated with the substrate. At least one of a size, location, and/or gaps between said conductive traces are tuned based on at least on of impedance and radiation pattern thereof.
摘要:
An RFID antenna is fabricated according to varying current density requirements of different regions of the antenna. A method such as computer modeling is used to determine the current densities of the antenna regions. In one aspect of the invention, a conductive material is printed to a substrate at varying thickness according to current density requirements of particular antenna regions. In another aspect of the invention, materials of different conductivity are printed to the substrate according to the current density requirements. A material of higher conductivity is printed at an antenna region that requires high current density, and a material of lower conductivity is printed at antenna region that requires lower current density.