发明申请
US20070274987A1 Expression of the cysteine protease legumain in vascular and inflammatory diseases
审中-公开
半胱氨酸蛋白酶在血管和炎症疾病中的表达
- 专利标题: Expression of the cysteine protease legumain in vascular and inflammatory diseases
- 专利标题(中): 半胱氨酸蛋白酶在血管和炎症疾病中的表达
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申请号: US11806000申请日: 2007-05-25
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公开(公告)号: US20070274987A1公开(公告)日: 2007-11-29
- 发明人: Valerie Clerin , Heather Shih , Kathleen Shields , Jeffrey Feldman , Gustave Hebert , Debra Pittman , Nanhua Deng
- 申请人: Valerie Clerin , Heather Shih , Kathleen Shields , Jeffrey Feldman , Gustave Hebert , Debra Pittman , Nanhua Deng
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; A61K38/17 ; C07H21/04 ; A61K39/00 ; C07K14/705 ; C07K16/28
摘要:
The present invention provides isolated and purified polynucleotides, polypeptides, and antibodies related to mammalian (e.g., mouse and human) legumain and the novel legumain splice variant, ZB-1. The invention further relates to the use of these isolated and purified polynucleotides, polypeptides, and antibodies, as well as other legumain and ZB-1 agonists and antagonists, in modulating legumain and/or ZB-1 activity, expression, and/or secretion in a cell or cell population, e.g., monocytes, macrophages, foam cells, vascular endothelial cells, kidney proximal tubule cells, arterial endothelial cells, sites of inflammatory cell invasion into a vessel intima, and neointimal lesional areas of an artery. The invention also provides legumain and ZB-1 antagonists, e.g., antagonistic small molecules, antibodies and antibody fragments to legumain and ZB-1, legumain and ZB-1 inhibitory polypeptides, and legumain and ZB-1 inhibitory polynucleotides. The present invention is also directed to novel methods for diagnosing, prognosing, monitoring, treating, ameliorating and/or preventing vascular disorders/diseases and inflammatory disorders/diseases.