公开(公告)号：US20070274987A1

公开(公告)日：2007-11-29

申请号：US11806000

申请日：2007-05-25

申请人： Valerie Clerin ,  Heather Shih ,  Kathleen Shields ,  Jeffrey Feldman ,  Gustave Hebert ,  Debra Pittman ,  Nanhua Deng

发明人： Valerie Clerin ,  Heather Shih ,  Kathleen Shields ,  Jeffrey Feldman ,  Gustave Hebert ,  Debra Pittman ,  Nanhua Deng

IPC分类号： A61K39/395 ,  A61K38/17 ,  C07H21/04 ,  A61K39/00 ,  C07K14/705 ,  C07K16/28

CPC分类号： C12N9/6472 ,  A61K38/00 ,  C12Y304/22034 ,  G01N33/5091 ,  G01N2333/95 ,  G01N2800/32

摘要： The present invention provides isolated and purified polynucleotides, polypeptides, and antibodies related to mammalian (e.g., mouse and human) legumain and the novel legumain splice variant, ZB-1. The invention further relates to the use of these isolated and purified polynucleotides, polypeptides, and antibodies, as well as other legumain and ZB-1 agonists and antagonists, in modulating legumain and/or ZB-1 activity, expression, and/or secretion in a cell or cell population, e.g., monocytes, macrophages, foam cells, vascular endothelial cells, kidney proximal tubule cells, arterial endothelial cells, sites of inflammatory cell invasion into a vessel intima, and neointimal lesional areas of an artery. The invention also provides legumain and ZB-1 antagonists, e.g., antagonistic small molecules, antibodies and antibody fragments to legumain and ZB-1, legumain and ZB-1 inhibitory polypeptides, and legumain and ZB-1 inhibitory polynucleotides. The present invention is also directed to novel methods for diagnosing, prognosing, monitoring, treating, ameliorating and/or preventing vascular disorders/diseases and inflammatory disorders/diseases.

摘要翻译： 本发明提供了与哺乳动物（例如，小鼠和人）legumain和新型legumain拼接变体ZB-1相关的分离和纯化的多核苷酸，多肽和抗体。 本发明还涉及这些分离和纯化的多核苷酸，多肽和抗体以及其他legumain和ZB-1激动剂和拮抗剂在调节legumain和/或ZB-1活性，表达和/或分泌中的用途 细胞或细胞群，例如单核细胞，巨噬细胞，泡沫细胞，血管内皮细胞，肾近端小管细胞，动脉内皮细胞，炎性细胞侵入血管内膜的部位和动脉的新内膜损伤区域。 本发明还提供legumain和ZB-1拮抗剂，例如对于legumain和ZB-1，legumain和ZB-1抑制性多肽的拮抗性小分子，抗体和抗体片段，以及legumain和ZB-1抑制性多核苷酸。 本发明还涉及用于诊断，预后，监测，治疗，改善和/或预防血管疾病/疾病和炎症性疾病/疾病的新颖方法。

公开(公告)号：US20100158924A1

公开(公告)日：2010-06-24

申请号：US12700178

申请日：2010-02-04

申请人： Valerie Clerin ,  Heather H. Shih ,  Kathleen Shields ,  Jeffrey Feldman ,  Gustave T. Hebert ,  Debra D. Pittman ,  Nanhua Dan Deng

发明人： Valerie Clerin ,  Heather H. Shih ,  Kathleen Shields ,  Jeffrey Feldman ,  Gustave T. Hebert ,  Debra D. Pittman ,  Nanhua Dan Deng

IPC分类号： A61K39/395 ,  C07H21/00 ,  C07K14/00 ,  C07K16/00 ,  A61K31/7052 ,  A61K38/02 ,  C12Q1/37 ,  A61P9/00 ,  A61P29/00

CPC分类号： C12N9/6472 ,  A61K38/00 ,  C12Y304/22034 ,  G01N33/5091 ,  G01N2333/95 ,  G01N2800/32

摘要： The present invention provides isolated and purified polynucleotides, polypeptides, and antibodies related to mammalian (e.g., mouse and human) legumain and the novel legumain splice variant, ZB-1. The invention further relates to the use of these isolated and purified polynucleotides, polypeptides, and antibodies, as well as other legumain and ZB-1 agonists and antagonists, in modulating legumain and/or ZB-1 activity, expression, and/or secretion in a cell or cell population, e.g., monocytes, macrophages, foam cells, vascular endothelial cells, kidney proximal tubule cells, arterial endothelial cells, sites of inflammatory cell invasion into a vessel intima, and neointimal lesional areas of an artery. The invention also provides legumain and ZB-1 antagonists, e.g., antagonistic small molecules, antibodies and antibody fragments to legumain and ZB-1, legumain and ZB-1 inhibitory polypeptides, and legumain and ZB-1 inhibitory polynucleotides. The present invention is also directed to novel methods for diagnosing, prognosing, monitoring, treating, ameliorating and/or preventing vascular disorders/diseases and inflammatory disorders/diseases.

摘要翻译： 本发明提供了与哺乳动物（例如，小鼠和人）legumain和新型legumain拼接变体ZB-1相关的分离和纯化的多核苷酸，多肽和抗体。 本发明还涉及这些分离和纯化的多核苷酸，多肽和抗体以及其他legumain和ZB-1激动剂和拮抗剂在调节legumain和/或ZB-1活性，表达和/或分泌中的用途 细胞或细胞群，例如单核细胞，巨噬细胞，泡沫细胞，血管内皮细胞，肾近端小管细胞，动脉内皮细胞，炎性细胞侵入血管内膜的部位和动脉的新内膜损伤区域。 本发明还提供legumain和ZB-1拮抗剂，例如对于legumain和ZB-1，legumain和ZB-1抑制性多肽的拮抗性小分子，抗体和抗体片段，以及legumain和ZB-1抑制性多核苷酸。 本发明还涉及用于诊断，预后，监测，治疗，改善和/或预防血管疾病/疾病和炎症性疾病/疾病的新颖方法。

公开(公告)号：US20050244849A1

公开(公告)日：2005-11-03

申请号：US11014625

申请日：2004-12-16

申请人： Debra Pittman ,  Jeffrey Feldman ,  Kathleen Shields ,  William Trepicchio

发明人： Debra Pittman ,  Jeffrey Feldman ,  Kathleen Shields ,  William Trepicchio

IPC分类号： A61K38/00 ,  C07K14/47 ,  C12Q1/68 ,  G01N33/48 ,  G01N33/50 ,  G01N33/53 ,  G06F19/00

CPC分类号： C07K14/4713 ,  A61K38/00

摘要： The invention provides methods for identifying, designing, and optimizing therapeutics for R.A using as targets one or more genes (and/or their encoded gene products) that have been shown to be up- or down-regulated in cells of R.A. relative to normal counterpart cells. Methods and compositions for diagnostic assays for detecting R.A. are also provided.

摘要翻译： 本发明提供了用于鉴定，设计和优化用于作为靶标的治疗的治疗方法，所述基因一个或多个基因（和/或其编码的基因产物）已被证明在R.A.的细胞中被上调或下调。 相对于正常的对应细胞。 用于检测R.A.的诊断测定法的方法和组合物 也提供。

公开(公告)号：US20060140933A1

公开(公告)日：2006-06-29

申请号：US10643589

申请日：2003-08-18

申请人： Debra Pittman ,  Brian Clancy ,  Glenn Larsen ,  William Trepicchio ,  Fionula Brennan ,  Marc Feldmann ,  Brian John Foxwell ,  Jeffrey Feldman

发明人： Debra Pittman ,  Brian Clancy ,  Glenn Larsen ,  William Trepicchio ,  Fionula Brennan ,  Marc Feldmann ,  Brian John Foxwell ,  Jeffrey Feldman

IPC分类号： A61K39/395 ,  C07K16/46

CPC分类号： C07K14/70503 ,  C07K2319/30 ,  C07K2319/70

摘要： Fusion proteins comprising a Receptor for Advanced Glycation End Products Ligand Binding Element (RAGE-LBE) and an immunoglobulin element are disclosed. Also disclosed are fusion proteins comprising a RAGE-LBE and a dimerization domain. Also disclosed are nucleic acids encoding such fusion proteins and methods for using disclosed nucleic acids and proteins to, for example, treat RAGE-related disorders. Additional compositions and methods are also disclosed.

摘要翻译： 公开了包含高级糖基末端产物配体结合元件（RAGE-LBE）的受体和免疫球蛋白元件的融合蛋白。 还公开了包含RAGE-LBE和二聚化结构域的融合蛋白。 还公开了编码这种融合蛋白的核酸和使用公开的核酸和蛋白质例如治疗RAGE相关病症的方法。 还公开了另外的组合物和方法。

公开(公告)号：US20060247996A1

公开(公告)日：2006-11-02

申请号：US11476830

申请日：2006-06-29

申请人： Jeffrey Feldman

发明人： Jeffrey Feldman

IPC分类号： G06Q40/00

CPC分类号： G06Q40/06 ,  G06Q40/00

摘要： An investment vehicle is formed according to novel selection methods which organize investment according to investor definitions of technology application. For example, healthcare companies can be organized according to their involvement with particular diagnostic or therapeutic modalities. The investment vehicle can then be used to back a structured note for use with a health savings account.

摘要翻译： 根据投资者技术应用定义组织投资的新选择方法，形成投资工具。 例如，医疗保健公司可以根据他们参与具体的诊断或治疗方式进行组织。 然后可以将投资工具用于支付结算票据以与健康储蓄账户一起使用。