发明申请
- 专利标题： Novel Gene Disruptions, Compositions and Methods Relating Thereto
- 专利标题（中）： 新型基因中断，组成和方法
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申请号： US10583466申请日： 2004-12-13
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公开(公告)号： US20070292438A1公开(公告)日： 2007-12-20
- 发明人: Stephen Anderson , Jane Brennan , Frederic de Sauvage , Zhiyong Ding , Joel Edwards , Nelda Fikes , Wenhu Huang , Wenjun Ouyang , Carolina Rangel , Mamta Sangha , Zheng-Zheng Shi , Mary Sparks , Joseph Trackey , Melissa Vetter , Ching-Yun Wang , Jessica Woodings
- 申请人： Stephen Anderson , Jane Brennan , Frederic de Sauvage , Zhiyong Ding , Joel Edwards , Nelda Fikes , Wenhu Huang , Wenjun Ouyang , Carolina Rangel , Mamta Sangha , Zheng-Zheng Shi , Mary Sparks , Joseph Trackey , Melissa Vetter , Ching-Yun Wang , Jessica Woodings
- 国际申请： PCT/US04/41721 WO 20041213
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/00 ; C12N5/00 ; C12N5/06 ; C12Q1/02 ; G01N33/00
摘要：
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO224, PRO9783, PRO1108, PRO34000, PRO240, PRO943, hu A33, PRO230, PRO178, PRO1199, PRO4333, PRO1336, PRO19598, PRO1083, hu TRPM2 or PRO1801 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
公开/授权文献
- US08067664B2 PRO224 gene disruptions, and methods related thereto 公开/授权日：2011-11-29