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公开(公告)号：US20070292438A1
公开(公告)日：2007-12-20
申请号：US10583466
申请日：2004-12-13
申请人： Stephen Anderson , Jane Brennan , Frederic de Sauvage , Zhiyong Ding , Joel Edwards , Nelda Fikes , Wenhu Huang , Wenjun Ouyang , Carolina Rangel , Mamta Sangha , Zheng-Zheng Shi , Mary Sparks , Joseph Trackey , Melissa Vetter , Ching-Yun Wang , Jessica Woodings
发明人： Stephen Anderson , Jane Brennan , Frederic de Sauvage , Zhiyong Ding , Joel Edwards , Nelda Fikes , Wenhu Huang , Wenjun Ouyang , Carolina Rangel , Mamta Sangha , Zheng-Zheng Shi , Mary Sparks , Joseph Trackey , Melissa Vetter , Ching-Yun Wang , Jessica Woodings
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0306
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO224, PRO9783, PRO1108, PRO34000, PRO240, PRO943, hu A33, PRO230, PRO178, PRO1199, PRO4333, PRO1336, PRO19598, PRO1083, hu TRPM2 or PRO1801 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地说，本发明提供包含PRO224，PRO9783，PRO1108，PRO34000，PRO240，PRO943，hu A33，PRO230，PRO178，PRO1199，PRO4333，PRO1336，PRO19598，PRO1083，hu TRPM2或PRO1801基因中的中断的转基因小鼠。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。
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公开(公告)号：US20120174239A1
公开(公告)日：2012-07-05
申请号：US13317754
申请日：2011-10-27
申请人： Stephen Jay Anderson , Jane Brennan , Frederic J. de Sauvage , Zhiyong Ding , Joel Edwards , Nelda A. Fikes , Wenhu Huang , Wenjun Ouyang , Carolina Rangel , Mamta Sangha , Zheng-Zheng Shi , Mary Jean Sparks , Joseph Trackey , Melissa Vetter , Ching-Yun Wang , Jessica Woodings
发明人： Stephen Jay Anderson , Jane Brennan , Frederic J. de Sauvage , Zhiyong Ding , Joel Edwards , Nelda A. Fikes , Wenhu Huang , Wenjun Ouyang , Carolina Rangel , Mamta Sangha , Zheng-Zheng Shi , Mary Jean Sparks , Joseph Trackey , Melissa Vetter , Ching-Yun Wang , Jessica Woodings
IPC分类号： G01N21/64 , G01N23/083 , C40B30/04 , G01N33/53
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0306
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO224, PRO9783, PRO1108, PRO34000, PRO240, PRO943, hu A33, PRO230, PRO178, PRO1199, PRO4333, PRO1336, PRO19598, PRO1083, hu TRPM2 or PRO1801 genes.Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地说，本发明提供包含PRO224，PRO9783，PRO1108，PRO34000，PRO240，PRO943，hu A33，PRO230，PRO178，PRO1199，PRO4333，PRO1336，PRO19598，PRO1083，hu TRPM2或PRO1801基因中的中断的转基因小鼠。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。
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3.发明授权Compositions and methods for the treatment of diseases and disorders associated with cytokine signaling 有权用于治疗与细胞因子信号传导相关的疾病和病症的组合物和方法公开(公告)号：US09555107B2
公开(公告)日：2017-01-31
申请号：US13404241
申请日：2012-02-24
申请人： Yvonne M. Chen , Anan Chuntharapai , Dimitry Danilenko , Wenjun Ouyang , Susan Sa , Patricia Valdez , Terence Wong , Jianfeng Wu , Yan Zheng
发明人： Yvonne M. Chen , Anan Chuntharapai , Dimitry Danilenko , Wenjun Ouyang , Susan Sa , Patricia Valdez , Terence Wong , Jianfeng Wu , Yan Zheng
CPC分类号： A61K39/3955 , A61K38/17 , A61K38/1793 , A61K38/20 , A61K2039/505 , A61K2039/57 , C07K16/244 , C07K16/2866 , C07K2317/76 , C07K2317/92
摘要： Compositions and methods are provided for the diagnosis and treatment of inflammation and autoimmune disorders, such as psoriasis. Compositions and methods for modulating IL-23 or IL-22 signaling are provided.
摘要翻译： 提供了用于诊断和治疗炎症和自身免疫性疾病如牛皮癣的组合物和方法。 提供了调节IL-23或IL-22信号传导的组合物和方法。
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公开(公告)号：US20110280828A1
公开(公告)日：2011-11-17
申请号：US13112850
申请日：2011-05-20
申请人： Alexander R. ABBAS , Nico P. Ghilardi , Zora Modrusan , Dimitry M. Danilenko , Frederic J. De Sauvage , Wenjun Ouyang , Patricia A. Valdez , Yan Zheng
发明人： Alexander R. ABBAS , Nico P. Ghilardi , Zora Modrusan , Dimitry M. Danilenko , Frederic J. De Sauvage , Wenjun Ouyang , Patricia A. Valdez , Yan Zheng
CPC分类号： A61K38/191 , A61K38/1709 , A61K38/20 , A61K38/204 , Y02A50/473
摘要： The present invention relates to compositions and methods for treatment of microbial disorder by modulation of the host immune response. More particularly, the present invention relates to compositions that mediate an anti-microbial immune response, and methods of treating a microbial infection using such compositions.
摘要翻译： 本发明涉及通过调节宿主免疫应答来治疗微生物病症的组合物和方法。 更具体地，本发明涉及介导抗微生物免疫应答的组合物，以及使用这些组合物治疗微生物感染的方法。
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5.发明申请公开(公告)号：US20100034817A1
公开(公告)日：2010-02-11
申请号：US12574818
申请日：2009-10-07
申请人： Alexander Abbas , Hilary Clark , Wenjun Ouyang , P. Mickey Williams , William I. Wood , Thomas D. Wu
发明人： Alexander Abbas , Hilary Clark , Wenjun Ouyang , P. Mickey Williams , William I. Wood , Thomas D. Wu
IPC分类号： A61K39/395 , C12Q1/68 , A61P37/04 , A61P37/06
CPC分类号： C12Q1/6837 , C07K14/47 , C12N9/2417 , C12Y302/01001 , G01N33/53 , G01N33/564 , G01N33/6893 , G01N2800/24
摘要： The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
摘要翻译： 本发明涉及含有新蛋白质的组合物和使用这些组合物来诊断和治疗免疫相关疾病的方法。
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公开(公告)号：US07479544B2
公开(公告)日：2009-01-20
申请号：US10987663
申请日：2004-11-12
申请人： Hilary Clark , Daniel L. Eaton , Bernd Wranik , Wenjun Ouyang , Lino Gonzalez , Austin L. Gurney , Kelly Loyet
发明人： Hilary Clark , Daniel L. Eaton , Bernd Wranik , Wenjun Ouyang , Lino Gonzalez , Austin L. Gurney , Kelly Loyet
IPC分类号： C07K16/00 , C07K16/28 , A61K39/395 , G01N33/53
CPC分类号： C07K14/705 , A61K38/00 , C07K16/28 , C07K2319/00 , G01N33/5011 , G01N33/57407 , G01N33/6893 , G01N2333/705 , G01N2800/065 , G01N2800/24 , G01N2800/245
摘要： The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related disease.
摘要翻译： 本发明涉及含有新蛋白质的组合物和使用这些组合物来诊断和治疗免疫相关疾病的方法。
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7.发明申请公开(公告)号：US20070184444A1
公开(公告)日：2007-08-09
申请号：US10567939
申请日：2004-08-11
申请人： Alexander Abbas , Hilary Clark , Wenjun Ouyang , P. Mickey Williams , William Wood , Thomas Wu
发明人： Alexander Abbas , Hilary Clark , Wenjun Ouyang , P. Mickey Williams , William Wood , Thomas Wu
IPC分类号： C12Q1/68 , G01N33/567 , C07K14/74 , C07K16/28 , C07H21/04
CPC分类号： C12Q1/6837 , C07K14/47 , C12N9/2417 , C12Y302/01001 , G01N33/53 , G01N33/564 , G01N33/6893 , G01N2800/24
摘要： The present invention relates to composition containing novel proteins and method of using those compositions for the dignosis and treatment of immune related diseases.
摘要翻译： 本发明涉及含有新蛋白质的组合物和使用这些组合物进行免疫相关疾病的治疗和治疗的方法。
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8.发明申请COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASES AND DISORDERS ASSOCIATED WITH CYTOKINE SIGNALING 审中-公开治疗与细胞因子信号相关的疾病和疾病的组合物和方法公开(公告)号：US20130224146A1
公开(公告)日：2013-08-29
申请号：US13404241
申请日：2012-02-24
申请人： Yvonne M. Chen , Anan Chuntharapai , Dimitry Danilenko , Wenjun Ouyang , Susan Sa , Patricia Valdez , Terence Wong , Jianfeng Wu , Yan Zheng
发明人： Yvonne M. Chen , Anan Chuntharapai , Dimitry Danilenko , Wenjun Ouyang , Susan Sa , Patricia Valdez , Terence Wong , Jianfeng Wu , Yan Zheng
IPC分类号： A61K39/395 , A61K38/20 , A61K38/17
CPC分类号： A61K39/3955 , A61K38/17 , A61K38/1793 , A61K38/20 , A61K2039/505 , A61K2039/57 , C07K16/244 , C07K16/2866 , C07K2317/76 , C07K2317/92
摘要： Compositions and methods are provided for the diagnosis and treatment of inflammation and autoimmune disorders, such as psoriasis. Compositions and methods for modulating IL-23 or IL-22 signaling are provided.
摘要翻译： 提供了用于诊断和治疗炎症和自身免疫性疾病如牛皮癣的组合物和方法。 提供了调节IL-23或IL-22信号传导的组合物和方法。
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9.发明申请公开(公告)号：US20130165332A1
公开(公告)日：2013-06-27
申请号：US13549297
申请日：2012-07-13
申请人： Alexander ABBAS , Hilary Clark , Wenjun Ouyang , P. Mickey Williams , William I. Wood , Thomas D. Wu
发明人： Alexander ABBAS , Hilary Clark , Wenjun Ouyang , P. Mickey Williams , William I. Wood , Thomas D. Wu
IPC分类号： G01N33/68
CPC分类号： C12Q1/6837 , C07K14/47 , C12N9/2417 , C12Y302/01001 , G01N33/53 , G01N33/564 , G01N33/6893 , G01N2800/24
摘要： The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
摘要翻译： 本发明涉及含有新蛋白质的组合物和使用这些组合物来诊断和治疗免疫相关疾病的方法。
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公开(公告)号：US20120201821A1
公开(公告)日：2012-08-09
申请号：US13317718
申请日：2011-10-25
IPC分类号： A61K39/395 , A61P1/04 , A61P1/00 , C07K16/28 , A61P29/00
CPC分类号： C07K16/2866 , A61K38/1793 , A61K38/191 , A61K38/2006 , C07K14/54 , C07K2317/76 , A61K2300/00
摘要： The present invention provides methods and means to reduce gastrointestinal inflammation. In particular, the invention provides methods and means to treat inflammatory bowel disease (IBD) and related conditions. The invention further provides methods and means to treat psoriasis. The invention further provides methods and means to treat asthma.
摘要翻译： 本发明提供了减少胃肠道炎症的方法和手段。 特别地，本发明提供治疗炎症性肠病（IBD）和相关病症的方法和手段。 本发明还提供治疗银屑病的方法和手段。 本发明还提供了治疗哮喘的方法和手段。
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