发明申请
US20080064094A1 Polynucleotides encoding two novel human G-protein coupled receptors, HGPRBMY28 and HGPRBMY29, and splice variants thereof
有权
编码两种新型人G蛋白偶联受体的多核苷酸HGPRBMY28和HGPRBMY29及其剪接变体
- 专利标题： Polynucleotides encoding two novel human G-protein coupled receptors, HGPRBMY28 and HGPRBMY29, and splice variants thereof
- 专利标题（中）： 编码两种新型人G蛋白偶联受体的多核苷酸HGPRBMY28和HGPRBMY29及其剪接变体
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申请号： US11890963申请日： 2007-08-08
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公开(公告)号： US20080064094A1公开(公告)日： 2008-03-13
- 发明人: John Feder , Chandra Ramanathan , Gabriel Mintier , David Bol , Donald Hawken
- 申请人： John Feder , Chandra Ramanathan , Gabriel Mintier , David Bol , Donald Hawken
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 主分类号： C12N5/00
- IPC分类号： C12N5/00 ; C07K1/00 ; C07K16/00
摘要：
The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
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