公开(公告)号：US20070196897A1

公开(公告)日：2007-08-23

申请号：US11071761

申请日：2005-03-03

申请人： John Feder ,  Chandra Ramanathan ,  Gabriel Mintier ,  David Bol ,  Donald Hawken

发明人： John Feder ,  Chandra Ramanathan ,  Gabriel Mintier ,  David Bol ,  Donald Hawken

IPC分类号： A61K38/17 ,  C07K14/705 ,  C07H21/04 ,  C12P21/06

CPC分类号： A61K49/0008 ,  A61K38/00 ,  C07K14/705 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/622 ,  Y10S435/975

摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。 本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US07223557B2

公开(公告)日：2007-05-29

申请号：US10153244

申请日：2002-05-22

申请人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Han Chang ,  Liana M. Le ,  Michael A. Blanar ,  David Bol

发明人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Han Chang ,  Liana M. Le ,  Michael A. Blanar ,  David Bol

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/02 ,  C12N5/06 ,  C07K14/705

CPC分类号： C07K14/705

摘要： The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel TRP-PLIK2, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码TRP-PLIK2多肽的新型多核苷酸，其片段和同源物。 本发明还提供分别编码TRP-PLIK2多肽，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d的变体和剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型TRP-PLIK2，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d多肽应用于诊断，治疗和/或预防与这些相关的各种疾病和/或病症的诊断和治疗方法 多肽。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US20060024665A1

公开(公告)日：2006-02-02

申请号：US11241347

申请日：2005-09-30

申请人： Lori Friedman ,  Gregory Plowman ,  Marcia Belvin ,  Helen Francis-Lang ,  Danxi Li ,  Roel Funke ,  Rolf Ryseck ,  Lata Jayaraman ,  David Bol ,  Matthew Lorenzi

发明人： Lori Friedman ,  Gregory Plowman ,  Marcia Belvin ,  Helen Francis-Lang ,  Danxi Li ,  Roel Funke ,  Rolf Ryseck ,  Lata Jayaraman ,  David Bol ,  Matthew Lorenzi

IPC分类号： C12Q1/00 ,  C12Q1/48

CPC分类号： G01N33/6872 ,  C12Q1/42 ,  G01N33/57496 ,  G01N2500/00

摘要： Human PRMT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of PRMT are provided.

公开(公告)号：US20050130286A1

公开(公告)日：2005-06-16

申请号：US10029345

申请日：2001-12-20

申请人： Donald Jackson ,  Chandra Ramanathan ,  John Feder ,  Gabe Mintier ,  Liana Lee ,  Thomas Nelson ,  Nathan Siemers ,  David Bol ,  Suzanne Suchard ,  Gary Schieven ,  Joshua Finger ,  C. Todderrud ,  Donna Bassolino ,  Stanley Krystek ,  Dana Banas ,  Patrick McAtee

发明人： Donald Jackson ,  Chandra Ramanathan ,  John Feder ,  Gabe Mintier ,  Liana Lee ,  Thomas Nelson ,  Nathan Siemers ,  David Bol ,  Suzanne Suchard ,  Gary Schieven ,  Joshua Finger ,  C. Todderrud ,  Donna Bassolino ,  Stanley Krystek ,  Dana Banas ,  Patrick McAtee

IPC分类号： A61K38/00 ,  A61K38/43 ,  A61K48/00 ,  A61P1/16 ,  A61P11/00 ,  A61P13/12 ,  A61P15/00 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07K16/40 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/16 ,  C12N15/09 ,  C12N15/55 ,  C12P21/00 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/573 ,  G01N33/68 ,  G06F19/16 ,  C07H21/04

CPC分类号： G06F19/16 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/30 ,  C12N9/16 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Y301/03048 ,  G01N33/573 ,  G01N33/6893 ,  G01N2333/916 ,  G01N2500/00 ,  G01N2500/04 ,  Y02A90/26

摘要： The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human phosphatase polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly cardiovascular diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供编码人磷酸酶多肽，其片段和同源物的新型多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型人磷酸酶多肽应用于诊断，治疗和/或预防与这些多肽，特别是心血管疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US20100015620A1

公开(公告)日：2010-01-21

申请号：US12448031

申请日：2007-12-06

申请人： Jeffrey W. Strovel ,  Pachai Natarajan ,  Tammy Purifoy ,  Marion Chakiath ,  David Bol ,  Juana Castaneda

发明人： Jeffrey W. Strovel ,  Pachai Natarajan ,  Tammy Purifoy ,  Marion Chakiath ,  David Bol ,  Juana Castaneda

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158

摘要： Sets of biomarker genes useful for monitoring exposure and response to anti-tumor agents that inhibit IMPDH and related biomolecules are disclosed along with methods for identifying such sets of genes, methods of using such sets to identify additional therapeutic agents as well as methods for stratifying patients into groups that are sensitive or resistant to such therapeutic agents. Methods of screening patients for recurrence of disease by monitoring changes in gene expression associated with malignancy are also described. The nucleotide sequence of such biomarkers are presented.

摘要翻译： 一些可用于监测对抑制IMPDH和相关生物分子的抗肿瘤剂的暴露和反应的生物标志物基因以及用于鉴定这样的基因组的方法，使用这些组来鉴定另外的治疗剂的方法以及分层患者的方法 成为对这种治疗剂敏感或抗性的组。 还描述了通过监测与恶性肿瘤相关的基因表达变化来筛选患者复发疾病的方法。 提出了这种生物标志物的核苷酸序列。

公开(公告)号：US07304141B2

公开(公告)日：2007-12-04

申请号：US11107572

申请日：2005-04-15

申请人： John N. Feder ,  Chandra S. Ramanathan ,  Gabriel A. Mintier ,  David Bol

发明人： John N. Feder ,  Chandra S. Ramanathan ,  Gabriel A. Mintier ,  David Bol

IPC分类号： C07K14/47 ,  C12N15/12 ,  C12N5/20 ,  C12P21/02

CPC分类号： C07K16/18 ,  A61K38/00 ,  A61K2039/53 ,  C07K14/47

摘要： The present invention provides novel polynucleotides encoding HLRRBM1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLRRBM1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly immune diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码HLRRBM1多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HLRRBM1多肽应用于诊断，治疗和/或预防与这些多肽，特别是免疫疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US20060014180A1

公开(公告)日：2006-01-19

申请号：US11143984

申请日：2005-06-02

申请人： Donald Jackson ,  Chandra Ramanathan ,  John Feder ,  Gabe Mintier ,  Liana Lee ,  Thomas Nelson ,  Nathan Siemers ,  David Bol ,  Suzanne Suchard ,  Gary Schieven ,  Joshua Finger ,  C. Todderrud ,  Donna Bassolino ,  Stanley Krystek ,  Dana Banas ,  Patrick McAtee

发明人： Donald Jackson ,  Chandra Ramanathan ,  John Feder ,  Gabe Mintier ,  Liana Lee ,  Thomas Nelson ,  Nathan Siemers ,  David Bol ,  Suzanne Suchard ,  Gary Schieven ,  Joshua Finger ,  C. Todderrud ,  Donna Bassolino ,  Stanley Krystek ,  Dana Banas ,  Patrick McAtee

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/16

CPC分类号： G06F19/16 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/30 ,  C12N9/16 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Y301/03048 ,  G01N33/573 ,  G01N33/6893 ,  G01N2333/916 ,  G01N2500/00 ,  G01N2500/04 ,  Y02A90/26

摘要： The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human phosphatase polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly cardiovascular diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供编码人磷酸酶多肽，其片段和同源物的新型多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型人磷酸酶多肽应用于诊断，治疗和/或预防与这些多肽，特别是心血管疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US20120010385A1

公开(公告)日：2012-01-12

申请号：US11891240

申请日：2007-08-09

申请人： John N. Feder ,  Chandra S. Ramanathan ,  Gabriel A. Mintier ,  David Bol ,  Donald R. Hawken

发明人： John N. Feder ,  Chandra S. Ramanathan ,  Gabriel A. Mintier ,  David Bol ,  Donald R. Hawken

IPC分类号： C07K14/00 ,  C07H21/04

CPC分类号： A61K49/0008 ,  A61K38/00 ,  C07K14/705 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/622 ,  Y10S435/975

摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。 本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US07427473B2

公开(公告)日：2008-09-23

申请号：US10590256

申请日：2005-02-24

申请人： Jeffrey W. Strovel ,  David Bol ,  Paul E. Young

发明人： Jeffrey W. Strovel ,  David Bol ,  Paul E. Young

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136

摘要： Methods for the identification of disease-related gene sets and expression nprofiles, based on common chemical modulation using a specific chemical compound are disclosed.

摘要翻译： 公开了基于使用特定化合物的常规化学调节的鉴定疾病相关基因组和表达谱的方法。

公开(公告)号：US07345148B2

公开(公告)日：2008-03-18

申请号：US11070456

申请日：2005-03-02

申请人： John N. Feder ,  Chandra S. Ramanathan ,  Gabriel A. Mintier ,  David Bol

发明人： John N. Feder ,  Chandra S. Ramanathan ,  Gabriel A. Mintier ,  David Bol

IPC分类号： C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  C12N1/20 ,  C12N15/74

CPC分类号： A61K49/0008 ,  A61K38/00 ,  C07K14/705 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/622 ,  Y10S435/975

摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。 本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。