发明申请
- 专利标题： Human Extracellular Matrix-1
- 专利标题（中）： 人细胞外基质-1
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申请号： US12105768申请日： 2008-04-18
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公开(公告)号： US20080200391A1公开(公告)日： 2008-08-21
- 发明人: Jian Ni , Ping Feng , Patrick J. Dillon , Reiner L. Gentz , Joseph Merregaert , Patrick Smits
- 申请人： Jian Ni , Ping Feng , Patrick J. Dillon , Reiner L. Gentz , Joseph Merregaert , Patrick Smits
- 申请人地址： US MD Rockville BE B-2610 Wilrijk
- 专利权人： HUMAN GENOME SCIENCES, INC.,THE UNIVERSITY OF ANTWERP
- 当前专利权人： HUMAN GENOME SCIENCES, INC.,THE UNIVERSITY OF ANTWERP
- 当前专利权人地址： US MD Rockville BE B-2610 Wilrijk
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; C07H21/00 ; C12N15/63 ; C12N5/00 ; C12P21/00 ; A61P19/00 ; C07K16/00 ; G01N33/00 ; C07K14/00
摘要：
A human ECM-1 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating the differentiation in growth of osteoblasts and osteoclasts, which may be used to promote the healing of bone fractures and de novo bone formation, for osteoporosis, for and to promote angiogenesis. Antagonists to the polypeptide of the present invention are also disclosed which may be utilized to treat osteodystrophy, osteohypertrophy, osteoma, osteoblastoma and cancers. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention.
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