Invention Application
- Patent Title: Genetic Inhibition of double-stranded RNA
- Patent Title (中): 双链RNA的遗传抑制
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Application No.: US11905368Application Date: 2007-09-28
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Publication No.: US20080248576A1Publication Date: 2008-10-09
- Inventor: Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
- Applicant: Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
- Applicant Address: US DC Washington US MA Boston
- Assignee: Carnegie Institution of Washington, the,University of Massachusetts, the
- Current Assignee: Carnegie Institution of Washington, the,University of Massachusetts, the
- Current Assignee Address: US DC Washington US MA Boston
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12N15/00
Abstract:
A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
Public/Granted literature
- US08283329B2 Genetic inhibition of double-stranded RNA Public/Granted day:2012-10-09
Information query
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