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1.发明申请公开(公告)号：US20080305543A1
公开(公告)日：2008-12-11
申请号：US11710152
申请日：2007-02-22
申请人： Craig C. Mello , Andrew Fire , Hiroaki Tabara , Alla Grishok
发明人： Craig C. Mello , Andrew Fire , Hiroaki Tabara , Alla Grishok
CPC分类号： C12N15/67 , C07K14/43545
摘要： Genes involved in double-stranded RNA interference (RNAi pathway genes) are identified and used to investigate the RNAi pathway. The genes and their products are also useful for modulating RNAi pathway activity.
摘要翻译： 鉴定涉及双链RNA干扰基因（RNAi途径基因）并用于研究RNAi途径。 基因及其产物也可用于调节RNAi通路活性。
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公开(公告)号：US07560438B2
公开(公告)日：2009-07-14
申请号：US10283190
申请日：2002-10-30
申请人： Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
发明人： Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
CPC分类号： C12N15/8285 , A01K2217/05 , A01K2227/703 , A61K31/7105 , A61K31/713 , C12N15/113 , C12N15/8218 , C12N15/85 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/50 , C12N2310/53
摘要： A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
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公开(公告)号：US20080081373A1
公开(公告)日：2008-04-03
申请号：US11905449
申请日：2007-10-01
申请人： Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel Driver , Craig Mello
发明人： Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel Driver , Craig Mello
IPC分类号： C12N15/87
CPC分类号： C12N15/8285 , A01K2217/05 , A01K2227/703 , A61K31/7105 , A61K31/713 , C12N15/113 , C12N15/8218 , C12N15/85 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/50 , C12N2310/53
摘要： A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
摘要翻译： 提供了将RNA引入活细胞以抑制该细胞中的靶基因的基因表达的方法。 该方法可以离体或体内实施。 RNA具有双链结构的区域。 抑制是序列特异性的，因为RNA的双链体区域和靶基因的一部分的核苷酸序列是相同的。 本发明不同于现有技术通过反义或三链方法进行基因表达的干扰。
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4.发明授权公开(公告)号：US07282564B2
公开(公告)日：2007-10-16
申请号：US10645746
申请日：2003-08-20
申请人： Craig C. Mello , Andrew Fire , Hiroaki Tabara , Alla Grishok
发明人： Craig C. Mello , Andrew Fire , Hiroaki Tabara , Alla Grishok
CPC分类号： C12N15/67 , C07K14/43545
摘要： Genes involved in double-stranded RNA interference (RNAi pathway genes) are identified and used to investigate the RNAi pathway. The genes and their products are also useful for modulating RNAi pathway activity.
摘要翻译： 鉴定涉及双链RNA干扰基因（RNAi途径基因）并用于研究RNAi途径。 基因及其产物也可用于调节RNAi通路活性。
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5.发明申请RNA interference pathway genes as tools for targeted genetic interference 审中-公开RNA干扰途径基因作为靶向遗传干扰的工具公开(公告)号：US20060024798A1
公开(公告)日：2006-02-02
申请号：US11144985
申请日：2005-06-03
申请人： Craig Mello , Andrew Fire , Hiroaki Tabara , Alla Grishok
发明人： Craig Mello , Andrew Fire , Hiroaki Tabara , Alla Grishok
CPC分类号： C12N15/67 , C07K14/43545
摘要： Genes involved in double-stranded RNA interference (RNAi pathway genes) are identified and used to investigate the RNAi pathway. The genes and their products are also useful for modulating RNAi pathway activity.
摘要翻译： 鉴定涉及双链RNA干扰基因（RNAi途径基因）并用于研究RNAi途径。 基因及其产物也可用于调节RNAi通路活性。
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6.发明申请RNA interference pathway genes as tools for targeted genetic interference 审中-公开RNA干扰途径基因作为靶向遗传干扰的工具公开(公告)号：US20050100913A1
公开(公告)日：2005-05-12
申请号：US10645735
申请日：2003-08-20
申请人： Craig Mello , Andrew Fire , Hiroaki Tabara , Alla Grishok
发明人： Craig Mello , Andrew Fire , Hiroaki Tabara , Alla Grishok
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , A61P43/00 , C07K14/435 , C07K16/18 , C12N5/10 , C12N15/67 , C12Q1/68 , C07H21/02 , C12N9/22
CPC分类号： C12N15/67 , C07K14/43545
摘要： Genes involved in double-stranded RNA interference (RNAi pathway genes) are identified and used to investigate the RNAi pathway. The genes and their products are also useful for modulating RNAi pathway activity.
摘要翻译： 鉴定涉及双链RNA干扰基因（RNAi途径基因）并用于研究RNAi途径。 基因及其产物也可用于调节RNAi通路活性。
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公开(公告)号：US08283329B2
公开(公告)日：2012-10-09
申请号：US11905368
申请日：2007-09-28
申请人： Andrew Z. Fire , Stephen A. Kostas , Mary K. Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
发明人： Andrew Z. Fire , Stephen A. Kostas , Mary K. Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
CPC分类号： C12N15/8285 , A01K2217/05 , A01K2227/703 , A61K31/7105 , A61K31/713 , C12N15/113 , C12N15/8218 , C12N15/85 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/50 , C12N2310/53
摘要： A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
摘要翻译： 提供了将RNA引入活细胞以抑制该细胞中的靶基因的基因表达的方法。 该方法可以离体或体内实施。 RNA具有双链结构的区域。 抑制是序列特异性的，因为RNA的双链体区域和靶基因的一部分的核苷酸序列是相同的。 本发明不同于现有技术通过反义或三链方法进行基因表达的干扰。
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公开(公告)号：US20080050342A1
公开(公告)日：2008-02-28
申请号：US11826385
申请日：2007-07-13
申请人： Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel Driver , Craig Mello
发明人： Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel Driver , Craig Mello
CPC分类号： C12N15/8285 , A01K2217/05 , A01K2227/703 , A61K31/7105 , A61K31/713 , C12N15/113 , C12N15/8218 , C12N15/85 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/50 , C12N2310/53
摘要： A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
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公开(公告)号：US06506559B1
公开(公告)日：2003-01-14
申请号：US09215257
申请日：1998-12-18
申请人： Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
发明人： Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
IPC分类号： C12Q168
CPC分类号： C12N15/8285 , A01K2217/05 , A01K2227/703 , A61K31/7105 , A61K31/713 , C12N15/113 , C12N15/8218 , C12N15/85 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/50 , C12N2310/53
摘要： A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
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公开(公告)号：US08580754B2
公开(公告)日：2013-11-12
申请号：US11905449
申请日：2007-10-01
申请人： Andrew Z. Fire , Stephen A. Kostas , Mary K. Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
发明人： Andrew Z. Fire , Stephen A. Kostas , Mary K. Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
IPC分类号： C12N15/113 , C07H21/04
CPC分类号： C12N15/8285 , A01K2217/05 , A01K2227/703 , A61K31/7105 , A61K31/713 , C12N15/113 , C12N15/8218 , C12N15/85 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/50 , C12N2310/53
摘要： A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
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