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公开(公告)号：US08580754B2
公开(公告)日：2013-11-12
申请号：US11905449
申请日：2007-10-01
Applicant: Andrew Z. Fire , Stephen A. Kostas , Mary K. Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
Inventor： Andrew Z. Fire , Stephen A. Kostas , Mary K. Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
IPC: C12N15/113 , C07H21/04
CPC classification number: C12N15/8285 , A01K2217/05 , A01K2227/703 , A61K31/7105 , A61K31/713 , C12N15/113 , C12N15/8218 , C12N15/85 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/50 , C12N2310/53
Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
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公开(公告)号：US20130029425A1
公开(公告)日：2013-01-31
申请号：US13557995
申请日：2012-07-25
Applicant: Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
Inventor： Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
IPC: C12N15/82
CPC classification number: C12N15/8285 , A01K2217/05 , A01K2227/703 , A61K31/7105 , A61K31/713 , C12N15/113 , C12N15/8218 , C12N15/85 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/50 , C12N2310/53
Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
Abstract translation: 提供了将RNA引入活细胞以抑制该细胞中的靶基因的基因表达的方法。 该方法可以离体或体内实施。 RNA具有双链结构的区域。 抑制是序列特异性的，因为RNA的双链体区域和靶基因的一部分的核苷酸序列是相同的。 本发明不同于现有技术通过反义或三链方法进行基因表达的干扰。
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3.发明授权公开(公告)号：US07691995B2
公开(公告)日：2010-04-06
申请号：US10195034
申请日：2002-07-12
Applicant: Phillip D. Zamore , Juanita McLachlan , Gyorgy Hutvagner , Alla Grishok , Craig C. Mello
Inventor： Phillip D. Zamore , Juanita McLachlan , Gyorgy Hutvagner , Alla Grishok , Craig C. Mello
IPC: C07H21/04
CPC classification number: C12N15/113 , A01K2217/05 , A01K2227/105 , A01K2267/03 , C12N15/111 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/30 , C12N2330/30 , C12N2330/51 , C12N2517/02 , C12N2799/021 , C12N2830/008
Abstract: The invention provides engineered RNA precursors that when expressed in a cell are processed by the cell to produce targeted small interfering RNAs (siRNAs) that selectively silence targeted genes (by cleaving specific mRNAs) using the cell's own RNA interference (RNAi) pathway. By introducing nucleic acid molecules that encode these engineered RNA precursors into cells in vivo with appropriate regulatory sequences, expression of the engineered RNA precursors can be selectively controlled both temporally and spatially, i.e., at particular times and/or in particular tissues, organs, or cells.
Abstract translation: 本发明提供了工程化的RNA前体，其在细胞中表达时被细胞加工以产生靶向小干扰RNA（siRNA），其使用细胞自身的RNA干扰（RNAi）途径选择性沉默靶基因（通过切割特异性mRNA）。 通过将具有合适的调节序列将这些工程化RNA前体编码的核酸分子引入细胞体内，工程化RNA前体的表达可以在时间和空间上选择性地控制，即在特定时间和/或特别是组织，器官或 细胞。
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公开(公告)号：US07622633B2
公开(公告)日：2009-11-24
申请号：US10283267
申请日：2002-10-30
Applicant: Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
Inventor： Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
CPC classification number: C12N15/8285 , A01K2217/05 , A01K2227/703 , A61K31/7105 , A61K31/713 , C12N15/113 , C12N15/8218 , C12N15/85 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/50 , C12N2310/53
Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
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公开(公告)号：US07538095B2
公开(公告)日：2009-05-26
申请号：US10282996
申请日：2002-10-30
Applicant: Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
Inventor： Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
CPC classification number: C12N15/8285 , A01K2217/05 , A01K2227/703 , A61K31/7105 , A61K31/713 , C12N15/113 , C12N15/8218 , C12N15/85 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/50 , C12N2310/53
Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
Abstract translation: 提供了将RNA引入活细胞以抑制该细胞中的靶基因的基因表达的方法。 该方法可以离体或体内实施。 RNA具有双链结构的区域。 抑制是序列特异性的，因为RNA的双链体区域和靶基因的一部分的核苷酸序列是相同的。 本发明不同于现有技术通过反义或三链方法进行基因表达的干扰。
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Patent Agency Ranking
6.发明授权公开(公告)号：US07759463B2
公开(公告)日：2010-07-20
申请号：US11710152
申请日：2007-02-22
Applicant: Craig C. Mello , Hiroaki Tabara , Andrew Fire , Alla Grishok
Inventor： Craig C. Mello , Hiroaki Tabara , Andrew Fire , Alla Grishok
CPC classification number: C12N15/67 , C07K14/43545
Abstract: Genes involved in double-stranded RNA interference (RNAi pathway genes) are identified and used to investigate the RNAi pathway. The genes and their products are also useful for modulating RNAi pathway activity.
Abstract translation: 鉴定涉及双链RNA干扰基因（RNAi途径基因）并用于研究RNAi途径。 基因及其产物也可用于调节RNAi通路活性。
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公开(公告)号：US20080248576A1
公开(公告)日：2008-10-09
申请号：US11905368
申请日：2007-09-28
Applicant: Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
Inventor： Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
CPC classification number: C12N15/8285 , A01K2217/05 , A01K2227/703 , A61K31/7105 , A61K31/713 , C12N15/113 , C12N15/8218 , C12N15/85 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/50 , C12N2310/53
Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
Abstract translation: 提供了将RNA引入活细胞以抑制该细胞中的靶基因的基因表达的方法。 该方法可以离体或体内实施。 RNA具有双链结构的区域。 抑制是序列特异性的，因为RNA的双链体区域和靶基因的一部分的核苷酸序列是相同的。 本发明不同于现有技术通过反义或三链方法进行基因表达的干扰。
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公开(公告)号：US08530438B2
公开(公告)日：2013-09-10
申请号：US12727783
申请日：2010-03-19
Applicant: Phillip D. Zamore , Juanita McLachlan , Gyorgy Hutvagner , Alla Grishok , Craig C. Mello
Inventor： Phillip D. Zamore , Juanita McLachlan , Gyorgy Hutvagner , Alla Grishok , Craig C. Mello
IPC: C12N15/11
CPC classification number: C12N15/113 , A01K2217/05 , A01K2227/105 , A01K2267/03 , C12N15/111 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/30 , C12N2330/30 , C12N2330/51 , C12N2517/02 , C12N2799/021 , C12N2830/008
Abstract: The invention provides engineered RNA precursors that when expressed in a cell are processed by the cell to produce targeted small interfering RNAs (siRNAs) that selectively silence targeted genes (by cleaving specific mRNAs) using the cell's own RNA interference (RNAi) pathway. By introducing nucleic acid molecules that encode these engineered RNA precursors into cells in vivo with appropriate regulatory sequences, expression of the engineered RNA precursors can be selectively controlled both temporally and spatially, i.e., at particular times and/or in particular tissues, organs, or cells.
Abstract translation: 本发明提供了工程化的RNA前体，其在细胞中表达时被细胞加工以产生靶向小干扰RNA（siRNA），其使用细胞自身的RNA干扰（RNAi）途径选择性沉默靶基因（通过切割特异性mRNA）。 通过将具有合适的调节序列将这些工程化RNA前体编码的核酸分子引入细胞体内，工程化RNA前体的表达可以在时间和空间上选择性地控制，即在特定时间和/或特别是组织，器官或 细胞。
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9.发明授权公开(公告)号：US07893036B2
公开(公告)日：2011-02-22
申请号：US12079531
申请日：2008-03-26
Applicant: Phillip D. Zamore , Juanita McLachlan , Gyoergy Hutvagner , Alla Grishok , Craig C. Mello
Inventor： Phillip D. Zamore , Juanita McLachlan , Gyoergy Hutvagner , Alla Grishok , Craig C. Mello
CPC classification number: C12N15/113 , A01K2217/05 , A01K2227/105 , A01K2267/03 , C12N15/111 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/30 , C12N2330/30 , C12N2330/51 , C12N2517/02 , C12N2799/021 , C12N2830/008
Abstract: The invention provides engineered RNA precursors that when expressed in a cell are processed by the cell to produce targeted small interfering RNAs (siRNAs) that selectively silence targeted genes (by cleaving specific mRNAs) using the cell's own RNA interference (RNAi) pathway. By introducing nucleic acid molecules that encode these engineered RNA precursors into cells in vivo with appropriate regulatory sequences, expression of the engineered RNA precursors can be selectively controlled both temporally and spatially, i.e., at particular times and/or in particular tissues, organs, or cells.
Abstract translation: 本发明提供了工程化的RNA前体，其在细胞中表达时被细胞加工以产生靶向小干扰RNA（siRNA），其使用细胞自身的RNA干扰（RNAi）途径选择性沉默靶基因（通过切割特异性mRNA）。 通过将具有合适的调节序列将这些工程化RNA前体编码的核酸分子引入细胞体内，工程化RNA前体的表达可以在时间和空间上选择性地控制，即在特定时间和/或特别是组织，器官或 细胞。
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公开(公告)号：US07560438B2
公开(公告)日：2009-07-14
申请号：US10283190
申请日：2002-10-30
Applicant: Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
Inventor： Andrew Fire , Stephen Kostas , Mary Montgomery , Lisa Timmons , SiQun Xu , Hiroaki Tabara , Samuel E. Driver , Craig C. Mello
CPC classification number: C12N15/8285 , A01K2217/05 , A01K2227/703 , A61K31/7105 , A61K31/713 , C12N15/113 , C12N15/8218 , C12N15/85 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/50 , C12N2310/53
Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
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