发明申请
US20080249056A1 Methods of Altering an Immune Response Induced by Cpg Oligodeoxynucleotides
有权
改变Cpg寡脱氧核苷酸诱导的免疫反应的方法
- 专利标题： Methods of Altering an Immune Response Induced by Cpg Oligodeoxynucleotides
- 专利标题（中）： 改变Cpg寡脱氧核苷酸诱导的免疫反应的方法
-
申请号： US12065085申请日： 2006-08-28
-
公开(公告)号： US20080249056A1公开(公告)日： 2008-10-09
- 发明人: Dennis M. Klinman , Mayda Gursel , Ihsan Gursel
- 申请人： Dennis M. Klinman , Mayda Gursel , Ihsan Gursel
- 国际申请： PCT/US06/33774 WO 20060828
- 主分类号： A61K31/711
- IPC分类号： A61K31/711 ; C12N5/00 ; G01N33/53 ; C12Q1/68
摘要：
It is disclosed herein that agents that affect the activity and/or expression of CXCL16 can be used to alter the uptake of D-type CpG oligodeoxynucleotides (D ODNs). Methods of inducing an immune response are disclosed that include administering agents that increase the activity and/or expression of CXCL16 and a D ODN. Methods of decreasing an immune response to a CpG ODN are also disclosed. These methods include administering an agent that decreases the activity and/or expression of CXCL16. Compositions including one or more D-type ODNs and an agent that modulates that activity and/or expression of CXCL16 are provided.
公开/授权文献
信息查询
IPC分类:
