发明申请
- 专利标题： Acylated Piperidines as Glycine Transporter Inhibitors
- 专利标题（中）： 酰化哌啶酮作为甘氨酸转运蛋白抑制剂
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申请号： US11908151申请日： 2006-03-09
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公开(公告)号： US20080255144A1公开(公告)日： 2008-10-16
- 发明人: Daniel Marcus Bradley , Clive Leslie Branch , Wai Ngor Chan , Steven Coulton , Anthony William Dean , Paul Martin Doyle , Brian Evans , Martin Leonard Gilpin , Sharon Lisa Gough , Jacqueline Anne Macritchie , Howard Robert Marshall , David John Nash , Roderick Alan Porter , Simon Edward Ward
- 申请人： Daniel Marcus Bradley , Clive Leslie Branch , Wai Ngor Chan , Steven Coulton , Anthony William Dean , Paul Martin Doyle , Brian Evans , Martin Leonard Gilpin , Sharon Lisa Gough , Jacqueline Anne Macritchie , Howard Robert Marshall , David John Nash , Roderick Alan Porter , Simon Edward Ward
- 专利权人： Glaxo Group Limited
- 当前专利权人： Glaxo Group Limited
- 优先权： GB0505084.4 20050311
- 国际申请： PCT/EP06/02484 WO 20060309
- 主分类号： A61K31/496
- IPC分类号： A61K31/496 ; C07D241/04 ; C07D405/10 ; C07D401/10 ; A61P25/18 ; C07D401/04 ; A61K31/495
摘要：
The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.
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