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公开(公告)号：US20080255144A1
公开(公告)日：2008-10-16
申请号：US11908151
申请日：2006-03-09
申请人： Daniel Marcus Bradley , Clive Leslie Branch , Wai Ngor Chan , Steven Coulton , Anthony William Dean , Paul Martin Doyle , Brian Evans , Martin Leonard Gilpin , Sharon Lisa Gough , Jacqueline Anne Macritchie , Howard Robert Marshall , David John Nash , Roderick Alan Porter , Simon Edward Ward
发明人： Daniel Marcus Bradley , Clive Leslie Branch , Wai Ngor Chan , Steven Coulton , Anthony William Dean , Paul Martin Doyle , Brian Evans , Martin Leonard Gilpin , Sharon Lisa Gough , Jacqueline Anne Macritchie , Howard Robert Marshall , David John Nash , Roderick Alan Porter , Simon Edward Ward
IPC分类号： A61K31/496 , C07D241/04 , C07D405/10 , C07D401/10 , A61P25/18 , C07D401/04 , A61K31/495
CPC分类号： C07D231/12 , C07D209/08 , C07D213/56 , C07D213/74 , C07D295/192 , C07D307/54 , C07D333/24 , C07D405/12 , C07D471/04
摘要： The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.
摘要翻译： 本发明提供式（I）化合物或其盐或溶剂合物：其中R 1，n，X，Y和Z如说明书中所定义，以及这些化合物的用途。 该化合物抑制GlyT1转运蛋白并且可用于治疗某些神经和神经精神障碍，包括精神分裂症。
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公开(公告)号：US20080287547A1
公开(公告)日：2008-11-20
申请号：US11718333
申请日：2005-12-21
申请人： Daniel Marcus Bradley , Clive Leslie Branch , Wai Ngor Chan , Steven Coulton , Martin Leonard Gilpin , Andrew Jonathan Harris , Albert Andrzej Jaxa-Chamiec , Justine Yeun Quai Lai , Jacqueline Anne Macritchie , Howard Robert Marshall , David John Nash , Roderick Alan Porter , Simone Spada , Kevin Michael Thewlis , Simon Edward Ward
发明人： Daniel Marcus Bradley , Clive Leslie Branch , Wai Ngor Chan , Steven Coulton , Martin Leonard Gilpin , Andrew Jonathan Harris , Albert Andrzej Jaxa-Chamiec , Justine Yeun Quai Lai , Jacqueline Anne Macritchie , Howard Robert Marshall , David John Nash , Roderick Alan Porter , Simone Spada , Kevin Michael Thewlis , Simon Edward Ward
IPC分类号： A61K31/166 , A61P25/00 , C07C233/65 , A61P25/18
CPC分类号： C07C233/78 , C07C235/50 , C07C235/60 , C07C323/62 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D205/04 , C07D207/20 , C07D209/02 , C07D295/13 , C07D307/22
摘要： The present invention relates to compounds of formula (I), or to salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.
摘要翻译： 本发明涉及式（I）化合物或其盐或溶剂化物，其用于制备用于治疗神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷障碍的药物。 本发明还包括制备这些化合物及其药物制剂的方法。
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公开(公告)号：US20090270510A1
公开(公告)日：2009-10-29
申请号：US11722213
申请日：2005-12-21
申请人： Daniel Marcus Bradley , Clive Leslie Branch , Wai Ngor Chan , Steven Coulton , Martin Leonard Gilpin , Andrew Jonathan Harris , Justine Yeun Quai Lai , Jacqueline Anne Macritchie , Howard Robert Marshall , David John Nash , Roderick Alan Porter , Simone Spada , Kevin Michael Thewlis , Simon Edward Ward
发明人： Daniel Marcus Bradley , Clive Leslie Branch , Wai Ngor Chan , Steven Coulton , Martin Leonard Gilpin , Andrew Jonathan Harris , Justine Yeun Quai Lai , Jacqueline Anne Macritchie , Howard Robert Marshall , David John Nash , Roderick Alan Porter , Simone Spada , Kevin Michael Thewlis , Simon Edward Ward
IPC分类号： A61K31/166 , C07C321/10 , C07C233/78 , C07C211/27
CPC分类号： C07C235/60 , C07C211/27 , C07C233/78 , C07C235/50 , C07C323/62
摘要： The present invention relates to compounds of formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.
摘要翻译： 本发明涉及式（I）化合物或其盐或溶剂合物，其用于制备用于治疗神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷障碍的药物。 本发明还包括制备这些化合物及其药物制剂的方法。
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公开(公告)号：US20100216837A1
公开(公告)日：2010-08-26
申请号：US11722210
申请日：2005-12-21
申请人： Andrea Bozzoli , Daniel Marcus Bradley , Steven Coulton , Martin Leonard Gilpin , Jacqueline Anne MacRitchie , Roderick Alan Porter , Kevin Michael Thewlis
发明人： Andrea Bozzoli , Daniel Marcus Bradley , Steven Coulton , Martin Leonard Gilpin , Jacqueline Anne MacRitchie , Roderick Alan Porter , Kevin Michael Thewlis
IPC分类号： A61K31/4709 , C07C231/06 , A61K31/166 , C07D215/50 , A61K31/47 , C07D333/06 , A61K31/381 , C07D207/04 , A61K31/40 , A61P25/00
CPC分类号： C07C211/36 , C07C211/29 , C07C229/34 , C07C233/78 , C07C271/22 , C07C2601/08 , C07D215/50 , C07D295/13 , C07D333/20 , C07D409/12
摘要： The present invention relates to compounds of formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.
摘要翻译： 本发明涉及式（I）化合物或其盐或溶剂合物，其用于制备用于治疗神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷障碍的药物。 本发明还包括制备这些化合物及其药物制剂的方法。
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公开(公告)号：US20090286828A1
公开(公告)日：2009-11-19
申请号：US11722219
申请日：2005-12-21
申请人： Andrea Bozzoli , Clive Leslie Branch , Jacqueline Anne Macritchie , Howard Robert Marshall , Roderick Alan Porter , Simone Spada
发明人： Andrea Bozzoli , Clive Leslie Branch , Jacqueline Anne Macritchie , Howard Robert Marshall , Roderick Alan Porter , Simone Spada
IPC分类号： A61K31/47 , A61K31/4709 , A61K31/165 , C07D215/38 , C07C233/00 , C07D401/02
CPC分类号： C07C255/57 , C07C233/78 , C07C235/66 , C07C237/48 , C07C2601/08 , C07C2602/08 , C07D215/50 , C07D295/135 , C07D405/12
摘要： The present invention relates to compounds of formula (I), or to salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof. wherein R1 is a group selected from:
摘要翻译： 本发明涉及式（I）化合物或其盐或溶剂化物，其用于制备用于治疗神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷障碍的药物。 本发明还包括制备这些化合物及其药物制剂的方法。 其中R1是选自：
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6.发明申请OXYGEN CONTAINING HETEROCYCLES AS GLYCINE TRANSPORTER INHIBITING COMPOUNDS 审中-公开含氧化合物作为甘氨酸运输抑制剂的含氧化合物公开(公告)号：US20100137428A1
公开(公告)日：2010-06-03
申请号：US11722216
申请日：2005-12-21
申请人： Andrea Bozzoli , Clive Leslie Branch , Jacqueline Anne MacRitchie , Howard Robert Marshall , Roderick Alan Porter , Simone Spada
发明人： Andrea Bozzoli , Clive Leslie Branch , Jacqueline Anne MacRitchie , Howard Robert Marshall , Roderick Alan Porter , Simone Spada
IPC分类号： A61K31/36 , C07D307/87 , A61K31/343 , C07D317/46 , A61P25/18 , A61P25/28 , A61P25/00
CPC分类号： C07D307/84 , C07D317/48
摘要： The present invention relates to compounds of formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof. wherein R1 is a group selected from:
摘要翻译： 本发明涉及式（I）化合物或其盐或溶剂合物，其用于制备用于治疗神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷障碍的药物。 本发明还包括制备这些化合物及其药物制剂的方法。 其中R1是选自：
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公开(公告)号：US07928124B2
公开(公告)日：2011-04-19
申请号：US11926398
申请日：2007-10-29
申请人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp
发明人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp
IPC分类号： A61K31/4433 , A61K31/444 , C07D405/14
CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/04
摘要： Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.
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8.发明申请公开(公告)号：US20080318944A1
公开(公告)日：2008-12-25
申请号：US11926409
申请日：2007-10-29
申请人： Clive Leslie BRANCH , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth, Anne Stead , Geoffrey Stemp
发明人： Clive Leslie BRANCH , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth, Anne Stead , Geoffrey Stemp
IPC分类号： A61K31/454 , A61P3/04 , C07D405/06 , C07D417/14 , C07D405/14 , C07D413/14 , C07D401/14 , A61K31/506 , A61K31/4545 , A61K31/5377 , A61K31/4525
CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/04
摘要： Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.
摘要翻译： 公开了具有下式的N-芳酰基环胺衍生物：其中变量如本文所定义，以及它们作为药物的用途，特别是作为食欲素受体拮抗剂。
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公开(公告)号：US07893090B2
公开(公告)日：2011-02-22
申请号：US11928072
申请日：2007-10-30
申请人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp
发明人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp
IPC分类号： A61K31/4525 , C07D401/06
CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/04
摘要： Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.
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公开(公告)号：US20090012083A1
公开(公告)日：2009-01-08
申请号：US11926398
申请日：2007-10-29
申请人： Clive Leslie BRANCH , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth, Anne Stead , Geoffrey Stemp
发明人： Clive Leslie BRANCH , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth, Anne Stead , Geoffrey Stemp
IPC分类号： A61K31/454 , A61P3/04 , C07D417/14 , C07D405/14 , C07D413/14 , C07D405/06 , A61K31/4709 , A61K31/5377 , A61K31/506 , A61K31/4725 , A61K31/4545 , C07D401/14 , C07D401/06 , C07D409/14 , A61K31/4525
CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/04
摘要： Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.
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