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公开(公告)号：US07566786B2
公开(公告)日：2009-07-28
申请号：US10557079
申请日：2004-05-19
申请人： Ian Robert Baldwin , Michael David Barker , Anthony William Dean , Colin David Eldred , Brian Evans , Sharon Lisa Gough , Stephen Barry Guntrip , Julie Nicole Hamblin , Stuart Holman , Paul Jones , Mika Kristian Lindvall , Christopher James Lunniss , Tracy Jane Redfern , Alison Judith Redgrave , John Edward Robinson , Michael Woodrow
发明人： Ian Robert Baldwin , Michael David Barker , Anthony William Dean , Colin David Eldred , Brian Evans , Sharon Lisa Gough , Stephen Barry Guntrip , Julie Nicole Hamblin , Stuart Holman , Paul Jones , Mika Kristian Lindvall , Christopher James Lunniss , Tracy Jane Redfern , Alison Judith Redgrave , John Edward Robinson , Michael Woodrow
IPC分类号： C07D215/38 , C07D215/44
CPC分类号： C07D401/12 , C07D215/54 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02
摘要： There are provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R19, R20, and R34 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
摘要翻译： 根据本发明提供新的式（I）化合物或其药学上可接受的盐，其中R1，R2，R19，R20和R34如说明书中所述，其制备方法，含有它们的制剂及其在 治疗炎症性疾病。
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2.发明申请Glyt1 Transporter Inhibitors and Uses Thereof in Treatment of Neurological and Neuropsychiatric Disorders 审中-公开Glyt1转运蛋白抑制剂及其在神经和神经精神障碍治疗中的应用公开(公告)号：US20080221185A1
公开(公告)日：2008-09-11
申请号：US11997427
申请日：2006-07-31
IPC分类号： A61K31/4184 , C07D235/02 , A61P25/18
CPC分类号： C07D235/02
摘要： The invention provides a compound of formula (I) or a solvate thereof: wherein R1, R2, R3, R4, R5, R6, and n are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.
摘要翻译： 本发明提供式（I）化合物或其溶剂化物：其中R 1，R 2，R 3，R 3， R 5，R 5，R 6和n如说明书中所定义，以及这些化合物的用途。 该化合物抑制GlyT1转运蛋白并且可用于治疗某些神经和神经精神障碍，包括精神分裂症。
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公开(公告)号：US20100022486A1
公开(公告)日：2010-01-28
申请号：US12519612
申请日：2007-12-19
申请人： Anne Marie Jeanne Bouillot , Alain Claude-Marie Daugan , Anthony William Dean , Martin Christian Fillmore
发明人： Anne Marie Jeanne Bouillot , Alain Claude-Marie Daugan , Anthony William Dean , Martin Christian Fillmore
IPC分类号： A61K31/593 , C07D217/00 , A61K31/47 , A61P3/06 , A61P9/10 , A61P3/10 , A61P25/00 , A61K31/56
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14
摘要： The present invention relates to substituted 3-Aminopyrazole compounds of formula (I): and pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing them and their use in medicine. In particular, the invention relates to compounds for modulating SCD activity.
摘要翻译： 本发明涉及式（I）的取代的3-氨基吡唑化合物及其药学上可接受的盐，其含有它们的药物组合物及其在药物中的用途。 特别地，本发明涉及用于调节SCD活性的化合物。
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公开(公告)号：US20100120669A1
公开(公告)日：2010-05-13
申请号：US12528647
申请日：2008-02-26
申请人： Anne Marie Jeanne Bouillot , Thierry Boyer , Alain Claude-Marie Daugan , Anthony William Dean , Martin Christian Fillmore , Yann Lamotte
发明人： Anne Marie Jeanne Bouillot , Thierry Boyer , Alain Claude-Marie Daugan , Anthony William Dean , Martin Christian Fillmore , Yann Lamotte
IPC分类号： A61K38/12 , C07D217/00 , A61K31/47 , A61K31/56 , A61K31/593 , A61K31/65 , A61P9/00 , A61P3/04 , A61P3/10 , A61P35/00 , A61P25/00
CPC分类号： C07D417/12 , C07D417/14
摘要： The present invention relates to substituted thiadiazole compounds of the formula (I): and pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing them and their use in medicine. In particular, the invention relates to compounds for modulating SCD activity.
摘要翻译： 本发明涉及式（I）的取代噻二唑化合物及其药学上可接受的盐，涉及含有它们的药物组合物及其在药物中的用途。 特别地，本发明涉及用于调节SCD活性的化合物。
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公开(公告)号：US20100041696A1
公开(公告)日：2010-02-18
申请号：US12519877
申请日：2007-12-19
IPC分类号： A61K31/47 , C07D401/12
CPC分类号： C07D401/12
摘要： The present invention relates to substituted 4-Aminopyrazole compounds of the formula (I): and pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing them and their use in medicine. In particular, the invention relates to compounds for modulating SCD activity.
摘要翻译： 本发明涉及式（I）的取代的4-氨基吡唑化合物及其药学上可接受的盐，涉及含有它们的药物组合物及其在药物中的用途。 特别地，本发明涉及用于调节SCD活性的化合物。
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公开(公告)号：US20090312325A1
公开(公告)日：2009-12-17
申请号：US12474324
申请日：2009-05-29
申请人： Ian Robert Baldwin , Michael David Barker , Anthony William Dean , Colin David Eldred , Brian Evans , Sharon Lisa Gough , Stephen Barry Guntrip , Julie Nicole Hamblin , Stuart Holman , Paul Jones , Mika Kristian Lindvall , Christopher James Lunniss , Tracy Jane Redfern , Alison Judith Redgrave , John Edward Robinson , Michael Woodrow
发明人： Ian Robert Baldwin , Michael David Barker , Anthony William Dean , Colin David Eldred , Brian Evans , Sharon Lisa Gough , Stephen Barry Guntrip , Julie Nicole Hamblin , Stuart Holman , Paul Jones , Mika Kristian Lindvall , Christopher James Lunniss , Tracy Jane Redfern , Alison Judith Redgrave , John Edward Robinson , Michael Woodrow
IPC分类号： A61K31/4709 , C07D401/12 , C07D417/12 , C07D403/12 , C07D215/38 , A61K31/47 , A61K31/5377 , A61P29/00 , A61P37/08
CPC分类号： C07D401/12 , C07D215/54 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02
摘要： There are provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R19, R20, and R34 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
摘要翻译： 根据本发明提供新的式（I）化合物或其药学上可接受的盐，其中R1，R2，R19，R20和R34如说明书中所述，其制备方法，含有它们的制剂及其在 治疗炎症性疾病。
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公开(公告)号：US07572915B2
公开(公告)日：2009-08-11
申请号：US11349677
申请日：2006-02-08
IPC分类号： C07D215/38
CPC分类号： C07D401/12 , C07D215/54 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02
摘要： There are provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R19, R20, and R34 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
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公开(公告)号：US20080255144A1
公开(公告)日：2008-10-16
申请号：US11908151
申请日：2006-03-09
申请人： Daniel Marcus Bradley , Clive Leslie Branch , Wai Ngor Chan , Steven Coulton , Anthony William Dean , Paul Martin Doyle , Brian Evans , Martin Leonard Gilpin , Sharon Lisa Gough , Jacqueline Anne Macritchie , Howard Robert Marshall , David John Nash , Roderick Alan Porter , Simon Edward Ward
发明人： Daniel Marcus Bradley , Clive Leslie Branch , Wai Ngor Chan , Steven Coulton , Anthony William Dean , Paul Martin Doyle , Brian Evans , Martin Leonard Gilpin , Sharon Lisa Gough , Jacqueline Anne Macritchie , Howard Robert Marshall , David John Nash , Roderick Alan Porter , Simon Edward Ward
IPC分类号： A61K31/496 , C07D241/04 , C07D405/10 , C07D401/10 , A61P25/18 , C07D401/04 , A61K31/495
CPC分类号： C07D231/12 , C07D209/08 , C07D213/56 , C07D213/74 , C07D295/192 , C07D307/54 , C07D333/24 , C07D405/12 , C07D471/04
摘要： The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.
摘要翻译： 本发明提供式（I）化合物或其盐或溶剂合物：其中R 1，n，X，Y和Z如说明书中所定义，以及这些化合物的用途。 该化合物抑制GlyT1转运蛋白并且可用于治疗某些神经和神经精神障碍，包括精神分裂症。
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