发明申请
- 专利标题： Human Osteoclast Derived Cathepsin
- 专利标题（中）： 人类破骨细胞衍生的组织蛋白酶
-
申请号： US11756638申请日： 2007-06-01
-
公开(公告)号： US20080317754A1公开(公告)日： 2008-12-25
- 发明人: Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
- 申请人： Gregg A. Hastings , Mark D. Adams , Claire M. Fraser , Norman H. Lee , Ewen F. Kirkness , Judith A. Blake , Lisa M. Fitzgerald , Fred H. Drake , Maxine Gowan
- 申请人地址： US MD Rockville US PA Philadelphia
- 专利权人： Human Genome Sciences, Inc.,SmithKline Beecham Corp.
- 当前专利权人： Human Genome Sciences, Inc.,SmithKline Beecham Corp.
- 当前专利权人地址： US MD Rockville US PA Philadelphia
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C12N15/11 ; C12N15/00 ; C12N1/20 ; C12P21/04 ; G01N33/53 ; A61P31/00 ; C12N9/50 ; C07K16/18 ; A61K38/43 ; A61K31/7088
摘要：
Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.
信息查询
