发明申请
US20080318227A1 Intermediates and enzymes of the non-mevalonate isoprenoid pathway
审中-公开
非甲羟戊酸异戊二烯途径的中间体和酶
- 专利标题： Intermediates and enzymes of the non-mevalonate isoprenoid pathway
- 专利标题（中）： 非甲羟戊酸异戊二烯途径的中间体和酶
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申请号： US11897349申请日： 2007-08-30
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公开(公告)号： US20080318227A1公开(公告)日： 2008-12-25
- 发明人: Adelbert Bacher , Felix Rohdich , Petra Adam , Sabine Amslinger , Wolfgang Eisenreich , Stefan Hecht
- 申请人： Adelbert Bacher , Felix Rohdich , Petra Adam , Sabine Amslinger , Wolfgang Eisenreich , Stefan Hecht
- 优先权： DE10118166.3 20010411; DE10130236.3 20010622; DE10155084.7 20011109; DE10201458.2 20020116
- 主分类号： C12N9/10
- IPC分类号： C12N9/10 ; C12N15/54 ; C40B30/08 ; C40B30/06 ; C12N1/11 ; C12N1/15 ; C12N1/21 ; C12N5/10 ; A01K67/027 ; A01H5/00 ; C07F9/02 ; A61K31/66 ; C07K16/00 ; C12P21/02 ; G01N33/53 ; C12Q1/68 ; C12P9/00 ; C12N15/11
摘要：
The invention provides a protein in a form that is functional for the enzymatic conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate to 1-hydroxy-2-methyl-2-butenyl 4-diphosphate notably in its (E)-form of the non-mevalonate biosynthetic pathway to isoprenoids. The invention also provides a protein in a form that is functional for the enzymatic conversion of 1-hydroxy-2-methyl-2-butenyl 4-diphosphate, notably in its (E)-form, to isopentenyl diphosphate and/or dimethylallyl diphosphate. Further, screening methods for inhibitors of these proteins are provided. Further, 1-hydroxy-2-methyl-2-butenyl 4-diphosphate is provided and chemical and enzymatic methods of its preparation.
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