发明申请
- 专利标题： METHOD FOR IDENTIFYING TARGET PROTEIN OF DRUG AND METHOD FOR SCREENING THERAPEUTIC AGENT FOR DIABETES USING THE TARGET PROTEIN
- 专利标题（中）： 识别药物靶标蛋白的方法及使用目标蛋白筛选糖尿病治疗药物的方法
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申请号： US11909031申请日： 2006-08-09
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公开(公告)号： US20090041754A1公开(公告)日： 2009-02-12
- 发明人: Hideki Endoh , Hiroyuki Yokota , Masahiko Hayakawa , Shinji Soga
- 申请人： Hideki Endoh , Hiroyuki Yokota , Masahiko Hayakawa , Shinji Soga
- 申请人地址： JP Tokyo
- 专利权人： ASTELLAS PHARMA INC.
- 当前专利权人： ASTELLAS PHARMA INC.
- 当前专利权人地址： JP Tokyo
- 优先权： JP2005-234673 20050812; JP2005-279582 20050927
- 国际申请： PCT/JP2006/315745 WO 20060809
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; G01N33/68 ; G01N33/567 ; C12Q1/48 ; C07K2/00 ; C07H21/00 ; C12N5/06
摘要：
A method for identifying a target protein of a compound having a pharmacological action by detecting a tertiary structural change of a target protein by binding a compound having a pharmacological action to a target protein with the use of a molecular chaperone protein having a characteristic of binding to a protein by recognizing a tertiary structural change of the protein is disclosed. Further, a method for screening a therapeutic agent for diabetes using a target protein of biguanide which is a therapeutic agent for diabetes and was found by the identification method, a screening tool which can be used in the screening method and a pharmaceutical composition for treating diabetes containing a substance obtained by the screening method are disclosed.