发明申请
US20090093875A1 DRUG ELUTING STENTS WITH PROLONGED LOCAL ELUTION PROFILES WITH HIGH LOCAL CONCENTRATIONS AND LOW SYSTEMIC CONCENTRATIONS
审中-公开
具有高度局部浓度和较低系统浓度的局部升华型号的药物治疗
- 专利标题： DRUG ELUTING STENTS WITH PROLONGED LOCAL ELUTION PROFILES WITH HIGH LOCAL CONCENTRATIONS AND LOW SYSTEMIC CONCENTRATIONS
- 专利标题（中）： 具有高度局部浓度和较低系统浓度的局部升华型号的药物治疗
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申请号： US12112935申请日： 2008-04-30
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公开(公告)号： US20090093875A1公开(公告)日： 2009-04-09
- 发明人: Kent C. B. Stalker , Winnette S. McIntosh , Dudley S. Jayasinghe , Gregory C. Orr , John E. Papp , Lewis B. Schwartz
- 申请人： Kent C. B. Stalker , Winnette S. McIntosh , Dudley S. Jayasinghe , Gregory C. Orr , John E. Papp , Lewis B. Schwartz
- 申请人地址： US IL Abbott Park
- 专利权人： ABBOTT LABORATORIES
- 当前专利权人： ABBOTT LABORATORIES
- 当前专利权人地址： US IL Abbott Park
- 主分类号： A61F2/06
- IPC分类号： A61F2/06
摘要：
A drug eluting stent can include a stent body having a polymeric coating with a lipophilic and/or hydrophilic element. A drug that has a bioactivity that inhibits cell proliferation can be disposed in the polymeric coating. The drug can be present in the polymer at an amount greater than or equal to about 150 ug/cm2. The polymeric coating and drug are configured to cooperate so as to form a diffusion pathway with tissue when the stent is disposed in a body lumen such that the drug preferentially diffuses into the tissue over a body fluid passing through the body lumen such that a maximum systemic blood concentration of the drug is less than about 40 ng/ml.
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