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    DUAL ANTIPLATELET THERAPY AND TIME BASED RISK PREDICTION
    3.
    发明公开
    DUAL ANTIPLATELET THERAPY AND TIME BASED RISK PREDICTION 审中-公开

    公开(公告)号：US20240186019A1

    公开(公告)日：2024-06-06

    申请号：US18514454

    申请日：2023-11-20

    申请人： Abbott Laboratories

    发明人： Divine E. Ediebah ,  Jana R. Buccola ,  Ciaran Byrne

    IPC分类号： G16H50/30 ,  G16H50/20 ,  G16H50/70

    CPC分类号： G16H50/30 ,  G16H50/20 ,  G16H50/70

    摘要： Systems, apparatuses and methods may provide technology that automatically converts, by a machine learning model, a Shapley plot into a hazard ratio plot. The technology may also identify a set of preoperative baseline characteristics associated with a procedure on a pooled patient population, determine, by a machine learning model, a set of health failure probabilities for a target patient based on the set of preoperative baseline characteristic and a set of preoperative target characteristics, wherein the set of preoperative target characteristics correspond to the target client, and pair, by the machine learning model, each probability in the set of health failure probabilities with a postoperative dual antiplatelet therapy (DAPT) duration for the target patient.

    METHODS OF DIAGNOSING BRAIN INJURY
    6.
    发明公开
    METHODS OF DIAGNOSING BRAIN INJURY 审中-公开

    公开(公告)号：US20230295684A1

    公开(公告)日：2023-09-21

    申请号：US18147360

    申请日：2022-12-28

    申请人： Abbott Laboratories

    发明人： Beth McQuiston ,  Saul Datwyler ,  Raj Chandran

    IPC分类号： C12Q1/44 ,  G01N33/68 ,  A61B5/00

    CPC分类号： C12Q1/44 ,  A61B5/4064 ,  G01N33/68 ,  G01N2800/40

    摘要： Disclosed herein are methods and systems of determining whether a subject’s levels of GFAP, UCH-L1, or GFAP and UCH-L1 are elevated in a sample collected from the subject. The methods comprise determining whether the levels of GFAP, UCH-L1, or GFAP and UCH-L1 are elevated in the sample, and communicating the determination on or from an instrument. The methods may be used to aid in the diagnosis and evaluation of a subject (e.g., a human subject) that has sustained or may have sustained an injury to the head, such as to determine whether the subject is suffering from a mild, moderate, severe, or moderate to severe traumatic brain injury (TBI).

    BOVINE MILK EXOSOME PRODUCTS AND METHODS, NUTRITIONAL COMPOSITIONS, AND THERAPEUTIC METHODS
    9.
    发明公开
    BOVINE MILK EXOSOME PRODUCTS AND METHODS, NUTRITIONAL COMPOSITIONS, AND THERAPEUTIC METHODS 审中-公开

    公开(公告)号：US20230263178A1

    公开(公告)日：2023-08-24

    申请号：US17907750

    申请日：2021-04-01

    申请人： Abbott Laboratories

    发明人： José María LÓPEZ PEDROSA ,  Ricardo RUEDA CABRERA ,  Jorge GARCÍA MARTÍNEZ

    IPC分类号： A23C9/142 ,  A23L33/00 ,  A61P3/10 ,  A61K35/20

    CPC分类号： A23C9/1425 ,  A23L33/40 ,  A61P3/10 ,  A61K35/20

    摘要： A method of obtaining an exosome-enriched product comprises providing a whey-containing bovine milk fraction, conducting a first centrifugation of the whey-containing bovine milk fraction to obtain a whey middle fraction, conducting a second centrifugation of the whey middle fraction at an increased speed to obtain a concentrated whey fraction, filtering the concentrated whey fraction to obtain a filtered whey fraction, and conducting a third centrifugation of the filtered whey fraction at a further increased speed to obtain an exosome-enriched product. The exosome-enriched product comprises intact exosomes and less than 5 wt % casein based on the total weight of protein in the exosome-enriched product. Nutritional compositions comprise protein, carbohydrate, and/or fat, and exosomes provided by addition of the exosome-enriched product. A method of improving insulin sensitivity in a subject comprises administering a nutritional composition comprising the exosome-enriched product.