公开(公告)号：US20090093875A1

公开(公告)日：2009-04-09

申请号：US12112935

申请日：2008-04-30

申请人： Kent C. B. Stalker ,  Winnette S. McIntosh ,  Dudley S. Jayasinghe ,  Gregory C. Orr ,  John E. Papp ,  Lewis B. Schwartz

发明人： Kent C. B. Stalker ,  Winnette S. McIntosh ,  Dudley S. Jayasinghe ,  Gregory C. Orr ,  John E. Papp ,  Lewis B. Schwartz

IPC分类号： A61F2/06

CPC分类号： A61F2/915 ,  A61F2/06 ,  A61F2002/91541 ,  A61F2002/91583 ,  A61F2250/0067 ,  A61L31/022 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2420/08

摘要： A drug eluting stent can include a stent body having a polymeric coating with a lipophilic and/or hydrophilic element. A drug that has a bioactivity that inhibits cell proliferation can be disposed in the polymeric coating. The drug can be present in the polymer at an amount greater than or equal to about 150 ug/cm2. The polymeric coating and drug are configured to cooperate so as to form a diffusion pathway with tissue when the stent is disposed in a body lumen such that the drug preferentially diffuses into the tissue over a body fluid passing through the body lumen such that a maximum systemic blood concentration of the drug is less than about 40 ng/ml.

摘要翻译： 药物洗脱支架可以包括具有亲脂和/或亲水元件的聚合物涂层的支架体。 具有抑制细胞增殖的生物活性的药物可以设置在聚合物涂层中。 药物可以以大于或等于约150μg/ cm 2的量存在于聚合物中。 聚合物涂层和药物被配置为配合以便当支架设置在体腔中时与组织形成扩散路径，使得药物优先地通过穿过体腔的体液扩散到组织中，使得最大系统 药物的血液浓度小于约40ng / ml。

公开(公告)号：US07252675B2

公开(公告)日：2007-08-07

申请号：US10260710

申请日：2002-09-30

申请人： Andy E. Denison ,  William J. Harrison ,  Benjamin C. Huter ,  Scott J. Huter ,  John E. Papp ,  Steven T. Saville ,  Kent C. B. Stalker

发明人： Andy E. Denison ,  William J. Harrison ,  Benjamin C. Huter ,  Scott J. Huter ,  John E. Papp ,  Steven T. Saville ,  Kent C. B. Stalker

IPC分类号： A61M29/00

CPC分类号： A61F2/013 ,  A61F2002/015 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/008

摘要： An expandable frame for an embolic filtering device used to capture embolic debris in a body vessel includes a first half frame having a first control arm connected to a second control arm by a partial loop and a second half frame having a first control arm connected to a second control arm by a partial loop. The partial loops cooperatively form a composite loop for attachment of a filtering element which will expand in the body vessel to capture embolic debris entrained in the fluid of the vessel. The lengths and positioning of the first and second control arms of each half frame can be varied to create an expandable frame which conforms to the size and shape of the body vessel in which the filtering device is deployed. Additionally, the radius of the partial loops, along with the length of the arc of the partial loops, can be varied on each of the frames to create a composite filtering assembly that can easily adapt to the size and shape of the body vessel. Additionally, the control arms of the half frames can be disposed either proximally or distally of the composite loop to create a distinct filtering structure.

摘要翻译： 用于捕获身体血管中的栓塞碎片的栓塞过滤装置的可膨胀框架包括：第一半框架，具有通过部分回路连接到第二控制臂的第一控制臂，以及具有连接到第二控制臂的第二控制臂的第二半框架 第二控制臂通过部分回路。 部分回路协同地形成用于附接过滤元件的复合回路，该过滤元件将在体内容器中膨胀以捕获携带在血管流体中的栓塞碎片。 可以改变每个半框架的第一和第二控制臂的长度和定位，以便产生符合过滤装置展开的身体容器的尺寸和形状的可扩张框架。 此外，部分回路的半径以及部分回路的圆弧的长度可以在每个框架上变化以产生可以容易地适应身体血管的尺寸和形状的复合过滤组件。 此外，半框架的控制臂可以在复合环路的近侧或远端设置，以产生不同的过滤结构。

公开(公告)号：US08672991B2

公开(公告)日：2014-03-18

申请号：US12724140

申请日：2010-03-15

申请人： William J. Boyle ,  Andy E. Denison ,  Benjamin C. Huter ,  Scott J. Huter ,  John E. Papp ,  Charles R. Peterson ,  Kent C. B. Stalker

发明人： William J. Boyle ,  Andy E. Denison ,  Benjamin C. Huter ,  Scott J. Huter ,  John E. Papp ,  Charles R. Peterson ,  Kent C. B. Stalker

IPC分类号： A61F2/06

CPC分类号： A61F2/013 ,  A61F2/95 ,  A61F2002/011 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/008

摘要： A deployment control system provides controlled deployment of an embolic protection device which may include a guide wire, an expandable filter attached to the guide wire near its distal end, and a restraining sheath that maintains the expanded filter in a collapsed position. The deployment control system includes a torque control device which allows the physician to torque the guide wire into the patient's anatomy and a mechanism for preventing the guide wire from buckling as the restraining sheath is being retracted to deploy the expandable filter. A recovery control system for recovering the embolic protection device includes an inner catheter which extends within a lumen of an outer recovery sheath in a coaxial arrangement. A distal portion of the inner catheter extends beyond another recovery sheath during advancement of the recovery system into the vasculature. The recovery sheath can be advanced over the inner catheter to collapse the expandable filter. The proximal ends of the inner catheter and recovery sheath include handle portions having snap mechanisms which hold the components together as the recovery system is being advanced into the patient's vasculature.

摘要翻译： 部署控制系统提供栓塞保护装置的可控部署，该栓塞保护装置可以包括引导线，在其远端附近附接到导丝的可扩张过滤器，以及将扩张过滤器保持在折叠位置的限制护套。 部署控制系统包括扭矩控制装置，该扭矩控制装置允许医师将导丝扭转到患者的解剖结构中，以及用于防止导线在收缩护套以展开可膨胀过滤器时弯曲的机构。 用于回收栓塞保护装置的恢复控制系统包括在同轴布置中在外部恢复护套的内腔内延伸的内导管。 在将回收系统推进脉管系统期间，内导管的远端部分延伸超过另一恢复护套。 恢复护套可以在内导管上推进以使可膨胀过滤器折叠。 内导管和恢复护套的近端包括手柄部分，其具有卡扣机构，当回收系统进入患者的脉管系统时，该部件将部件保持在一起。

公开(公告)号：US20110039013A1

公开(公告)日：2011-02-17

申请号：US12540302

申请日：2009-08-12

申请人： John E. Papp ,  Matthew J. Gillick ,  Kent C. B. Stalker

发明人： John E. Papp ,  Matthew J. Gillick ,  Kent C. B. Stalker

IPC分类号： B05D3/04 ,  B05C5/00 ,  B05C13/02 ,  B05C11/00

CPC分类号： F26B9/06 ,  A61F2/82 ,  A61F2310/00389 ,  A61L2420/02 ,  B05B13/0221 ,  B05B13/0228 ,  B05B13/041 ,  B05B16/20 ,  B05B16/60 ,  B05B16/90 ,  B05D1/002 ,  B05D1/02 ,  B05D3/0413 ,  B05D3/0493 ,  B05D7/584

摘要： A system and method allows for processing of two groups of medical devices, both groups being alternatingly spray coated within the same enclosure. The two groups repeatedly move back and forth between a spray area and a drying area which is isolated from the spray area. One group moves into the spray area as the other group moves out and into the drying area. Thereafter, the group in the spray area moves out and into the drying area and the other group moves back into the spraying area for a second coating. The alternating process may be repeated any number of times. The spray area may be located inside a sealed spray isolator enclosure and surrounded by gas discharge nozzles.

摘要翻译： 一种系统和方法允许处理两组医疗装置，两组在相同外壳内交替喷涂。 两组反复在喷雾区域和与喷雾区域隔离的干燥区域之间来回移动。 随着另一组移出并进入干燥区域，一组移入喷雾区域。 此后，喷雾区域中的组移出并进入干燥区域，而另一组移回喷涂区域进行第二次涂覆。 交替过程可以重复任意次数。 喷射区域可以位于密封的喷雾隔离器外壳内并被气体排放喷嘴包围。

公开(公告)号：US08567340B2

公开(公告)日：2013-10-29

申请号：US12540302

申请日：2009-08-12

申请人： John E. Papp ,  Matthew J. Gillick ,  Kent C. B. Stalker

发明人： John E. Papp ,  Matthew J. Gillick ,  Kent C. B. Stalker

IPC分类号： B05C5/02

CPC分类号： F26B9/06 ,  A61F2/82 ,  A61F2310/00389 ,  A61L2420/02 ,  B05B13/0221 ,  B05B13/0228 ,  B05B13/041 ,  B05B16/20 ,  B05B16/60 ,  B05B16/90 ,  B05D1/002 ,  B05D1/02 ,  B05D3/0413 ,  B05D3/0493 ,  B05D7/584

摘要： A system and method allows for processing of two groups of medical devices, both groups being alternatingly spray coated within the same enclosure. The two groups repeatedly move back and forth between a spray area and a drying area which is isolated from the spray area. One group moves into the spray area as the other group moves out and into the drying area. Thereafter, the group in the spray area moves out and into the drying area and the other group moves back into the spraying area for a second coating. The alternating process may be repeated any number of times. The spray area may be located inside a sealed spray isolator enclosure and surrounded by gas discharge nozzles.

摘要翻译： 一种系统和方法允许处理两组医疗装置，两组在相同外壳内交替喷涂。 两组反复在喷雾区域和与喷雾区域隔离的干燥区域之间来回移动。 随着另一组移出并进入干燥区域，一组移入喷雾区域。 此后，喷雾区域中的组移出并进入干燥区域，而另一组移回喷涂区域进行第二次涂覆。 交替过程可以重复任意次数。 喷射区域可以位于密封的喷雾隔离器外壳内并被气体排放喷嘴包围。

公开(公告)号：US07976560B2

公开(公告)日：2011-07-12

申请号：US11654426

申请日：2007-01-17

申请人： Andy E. Denison ,  William J. Harrison ,  Benjamin C. Huter ,  Scott J. Huter ,  John E. Papp ,  Steven T. Saville ,  Kent C. B. Stalker

发明人： Andy E. Denison ,  William J. Harrison ,  Benjamin C. Huter ,  Scott J. Huter ,  John E. Papp ,  Steven T. Saville ,  Kent C. B. Stalker

IPC分类号： A61M29/00

CPC分类号： A61F2/013 ,  A61F2002/015 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/008

摘要： An expandable frame for an embolic filtering device used to capture embolic debris in a body vessel includes a first half frame having a first control arm connected to a second control arm by a partial loop and a second half frame having a first control arm connected to a second control arm by a partial loop. The partial loops cooperatively form a composite loop for attachment of a filtering element which will expand in the body vessel to capture embolic debris entrained in the fluid of the vessel. The lengths and positioning of the first and second control arms of each half frame can be varied to create an expandable frame which conforms to the size and shape of the body vessel in which the filtering device is deployed. Additionally, the radius of the partial loops, along with the length of the arc of the partial loops, can be varied on each of the frames to create a composite filtering assembly that can easily adapt to the size and shape of the body vessel. Additionally, the control arms of the half frames can be disposed either proximally or distally of the composite loop to create a distinct filtering structure.

摘要翻译： 用于捕获身体血管中的栓塞碎片的栓塞过滤装置的可膨胀框架包括：第一半框架，具有通过部分回路连接到第二控制臂的第一控制臂，以及具有连接到第二控制臂的第二控制臂的第二半框架 第二控制臂通过部分回路。 部分回路协同地形成用于附接过滤元件的复合回路，该过滤元件将在体内容器中膨胀以捕获携带在血管流体中的栓塞碎片。 可以改变每个半框架的第一和第二控制臂的长度和定位，以便产生符合过滤装置展开的身体容器的尺寸和形状的可扩张框架。 此外，部分回路的半径以及部分回路的圆弧的长度可以在每个框架上变化以产生可以容易地适应身体血管的尺寸和形状的复合过滤组件。 此外，半框架的控制臂可以在复合环路的近侧或远端设置，以产生不同的过滤结构。

公开(公告)号：US07678128B2

公开(公告)日：2010-03-16

申请号：US09897295

申请日：2001-06-29

申请人： William J. Boyle ,  Andy E. Denison ,  Benjamin C. Huter ,  Scott J. Huter ,  John E. Papp ,  Charles R. Peterson ,  Kent C. B. Stalker

发明人： William J. Boyle ,  Andy E. Denison ,  Benjamin C. Huter ,  Scott J. Huter ,  John E. Papp ,  Charles R. Peterson ,  Kent C. B. Stalker

IPC分类号： A61M29/00

CPC分类号： A61F2/013 ,  A61F2/95 ,  A61F2002/011 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/008

摘要： A deployment control system provides controlled deployment of an embolic protection device which may include a guide wire, an expandable filter attached to the guide wire near its distal end, and a restraining sheath that maintains the expanded filter in a collapsed position. The deployment control system includes a torque control device which allows the physician to torque the guide wire into the patient's anatomy and a mechanism for preventing the guide wire from buckling as the restraining sheath is being retracted to deploy the expandable filter. A recovery control system for recovering the embolic protection device includes an inner catheter which extends within a lumen of an outer recovery sheath in a coaxial arrangement. A distal portion of the inner catheter extends beyond another recovery sheath during advancement of the recovery system into the vasculature. The recovery sheath can be advanced over the inner catheter to collapse the expandable filter. The proximal ends of the inner catheter and recovery sheath include handle portions having snap mechanisms which hold the components together as the recovery system is being advanced into the patient's vasculature.

摘要翻译： 部署控制系统提供栓塞保护装置的可控部署，该栓塞保护装置可以包括引导线，在其远端附近附接到导丝的可扩张过滤器，以及将扩张过滤器保持在折叠位置的限制护套。 部署控制系统包括扭矩控制装置，该扭矩控制装置允许医师将导丝扭转到患者的解剖结构中，以及用于防止导线在收缩护套以展开可膨胀过滤器时弯曲的机构。 用于回收栓塞保护装置的恢复控制系统包括在同轴布置中在外部恢复护套的内腔内延伸的内导管。 在将回收系统推进脉管系统期间，内导管的远端部分延伸超过另一恢复护套。 恢复护套可以在内导管上推进以使可膨胀过滤器折叠。 内导管和恢复护套的近端包括手柄部分，其具有卡扣机构，当回收系统进入患者的脉管系统时，该部件将部件保持在一起。

公开(公告)号：US08442656B2

公开(公告)日：2013-05-14

申请号：US11422014

申请日：2006-06-02

申请人： Bruce A. Tockman ,  Brian D. Soltis ,  Eric T. Johnson ,  Kent C. B. Stalker ,  Peter J. D'aquanni ,  Paul E. Zarembo

发明人： Bruce A. Tockman ,  Brian D. Soltis ,  Eric T. Johnson ,  Kent C. B. Stalker ,  Peter J. D'aquanni ,  Paul E. Zarembo

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N1/0573 ,  A61N2001/0585

摘要： A cardiac lead adapted for fixation at least partially within a cardiac vessel. The lead includes, in one embodiment, an elongate lead body defining a proximal region and a distal region including a distal end region having at least one electrode and a distal tip. The distal end region is configured such that the electrode and the distal tip can be implanted in the cardiac vessel. Stiffening structures in the distal region of the lead are adapted to stiffen selected portions of the lead for fixation of the electrode within the cardiac vessel. In some embodiments, the stiffening structures include an implantable member adapted to be implanted in a lumen of the lead. In other embodiments, the stiffening structures include a sheath adapted to be deployed over the lead body. In still other embodiments, the stiffening structures are integral to the lead and/or the lead body.

摘要翻译： 适于至少部分地固定在心脏血管内的心脏引线。 在一个实施例中，引线包括限定近端区域的细长引线体和包括具有至少一个电极和远端尖端的远端区域的远侧区域。 远端区域被构造成使得电极和远端尖端可以植入心脏血管。 铅的远端区域中的加强结构适于加强导线的选定部分，以将电极固定在心脏血管内。 在一些实施例中，加强结构包括适于植入在引导管腔中的可植入部件。 在其他实施例中，加强结构包括适于部署在引线主体上的护套。 在其他实施例中，加强结构与引线和/或引线主体成一体。

公开(公告)号：US20070282413A1

公开(公告)日：2007-12-06

申请号：US11422012

申请日：2006-06-02

申请人： Bruce A. Tockman ,  Brian D. Soltis ,  Eric T. Johnson ,  Kent C. B. Stalker ,  Peter J. D' aquanni ,  Paul E. Zarembo

发明人： Bruce A. Tockman ,  Brian D. Soltis ,  Eric T. Johnson ,  Kent C. B. Stalker ,  Peter J. D' aquanni ,  Paul E. Zarembo

IPC分类号： A61N1/05

CPC分类号： A61N1/057 ,  A61N2001/0585

摘要： A cardiac lead adapted for fixation at least partially within a cardiac vessel. The lead includes, in one embodiment, an elongate lead body defining a proximal region and a distal region including a distal end region having at least one electrode and a distal tip. The distal end region is configured such that the electrode and the distal tip can be implanted in the cardiac vessel. Stiffening structures in the distal region of the lead are adapted to stiffen selected portions of the lead for fixation of the electrode within the cardiac vessel. In some embodiments, the stiffening structures include an implantable member adapted to be implanted in a lumen of the lead. In other embodiments, the stiffening structures include a sheath adapted to be deployed over the lead body. In still other embodiments, the stiffening structures are integral to the lead and/or the lead body.

摘要翻译： 适于至少部分地固定在心脏血管内的心脏引线。 在一个实施例中，引线包括限定近端区域的细长引线体和包括具有至少一个电极和远端尖端的远端区域的远侧区域。 远端区域被构造成使得电极和远端尖端可以植入心脏血管。 铅的远端区域中的加强结构适于加强导线的选定部分，以将电极固定在心脏血管内。 在一些实施例中，加强结构包括适于植入在引导管腔中的可植入部件。 在其他实施例中，加强结构包括适于部署在引线主体上的护套。 在其他实施例中，加强结构与引线和/或引线主体成一体。

公开(公告)号：US06652576B1

公开(公告)日：2003-11-25

申请号：US09590307

申请日：2000-06-07

申请人： Kent C. B. Stalker

发明人： Kent C. B. Stalker

IPC分类号： A61F206

CPC分类号： A61F2/915 ,  A61F2/91 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2250/0018

摘要： A stent having a structure differentiated in terms of its stiffness. Such differentiation is achieved with the use of a superelastic material that transitions between a relatively soft and malleable phase to a stiffer phase at a transition temperature that is adjustable. By differentially adjusting the transition temperature of different portions of the stent, a differentiation of the stiffness of the structure is achieved upon the stent being subjected to body temperature.

摘要翻译： 具有在其刚度方面不同的结构的支架。 这种分化是通过使用在可调节的转变温度下在相对柔软和可延展的相之间转变成更硬相的超弹性材料来实现的。 通过差异调节支架的不同部分的转变温度，在支架经受体温后实现结构刚度的分化。