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1.发明申请DRUG ELUTING STENTS WITH PROLONGED LOCAL ELUTION PROFILES WITH HIGH LOCAL CONCENTRATIONS AND LOW SYSTEMIC CONCENTRATIONS 审中-公开具有高度局部浓度和较低系统浓度的局部升华型号的药物治疗公开(公告)号：US20090093875A1
公开(公告)日：2009-04-09
申请号：US12112935
申请日：2008-04-30
申请人： Kent C. B. Stalker , Winnette S. McIntosh , Dudley S. Jayasinghe , Gregory C. Orr , John E. Papp , Lewis B. Schwartz
发明人： Kent C. B. Stalker , Winnette S. McIntosh , Dudley S. Jayasinghe , Gregory C. Orr , John E. Papp , Lewis B. Schwartz
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/06 , A61F2002/91541 , A61F2002/91583 , A61F2250/0067 , A61L31/022 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2420/08
摘要： A drug eluting stent can include a stent body having a polymeric coating with a lipophilic and/or hydrophilic element. A drug that has a bioactivity that inhibits cell proliferation can be disposed in the polymeric coating. The drug can be present in the polymer at an amount greater than or equal to about 150 ug/cm2. The polymeric coating and drug are configured to cooperate so as to form a diffusion pathway with tissue when the stent is disposed in a body lumen such that the drug preferentially diffuses into the tissue over a body fluid passing through the body lumen such that a maximum systemic blood concentration of the drug is less than about 40 ng/ml.
摘要翻译： 药物洗脱支架可以包括具有亲脂和/或亲水元件的聚合物涂层的支架体。 具有抑制细胞增殖的生物活性的药物可以设置在聚合物涂层中。 药物可以以大于或等于约150μg/ cm 2的量存在于聚合物中。 聚合物涂层和药物被配置为配合以便当支架设置在体腔中时与组织形成扩散路径，使得药物优先地通过穿过体腔的体液扩散到组织中，使得最大系统 药物的血液浓度小于约40ng / ml。
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公开(公告)号：US06679909B2
公开(公告)日：2004-01-20
申请号：US09919490
申请日：2001-07-31
IPC分类号： A61F206
摘要： A catheter assembly is provided having an inner member and an outer member extending along a longitudinal axis, the inner member and the outer member having a coaxial configuration and dimensioned for relative axial movement. The outer member has a wall defining an opening such as a longitudinal slot; an expanding member such as a leaf spring is connected to the inner member, the leaf spring being adapted to engage with the longitudinal slot so as to maintain rotational alignment between inner member and outer member.
摘要翻译： 提供导管组件，其具有内部构件和沿着纵向轴线延伸的外部构件，内部构件和外部构件具有同轴构造并且被设计成用于相对轴向移动。 外部构件具有限定诸如纵向狭槽的开口的壁; 诸如片簧的扩展构件连接到内部构件，板簧适于与纵向狭槽接合，以便保持内部构件和外部构件之间的旋转对准。
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公开(公告)号：US07488342B2
公开(公告)日：2009-02-10
申请号：US10677591
申请日：2003-10-01
IPC分类号： A61F2/06
摘要： A catheter assembly is provided having an inner member and an outer member extending along a longitudinal axis, the inner member and the outer member having a coaxial configuration and dimensioned for relative axial movement. The outer member has a wall defining an opening such as a longitudinal slot; an expanding member such as a leaf spring is connected to the inner member, the leaf spring being adapted to engage with the longitudinal slot so as to maintain rotational alignment between inner member and outer member.
摘要翻译： 提供导管组件，其具有内部构件和沿着纵向轴线延伸的外部构件，内部构件和外部构件具有同轴构造并且被设计成用于相对轴向移动。 外部构件具有限定诸如纵向狭槽的开口的壁; 诸如片簧的扩展构件连接到内部构件，板簧适于与纵向狭槽接合，以便保持内部构件和外部构件之间的旋转对准。
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公开(公告)号：US20090228090A1
公开(公告)日：2009-09-10
申请号：US12364275
申请日：2009-02-02
IPC分类号： A61F2/84
摘要： A catheter assembly is provided having an inner member and an outer member extending along a longitudinal axis, the inner member and the outer member having a coaxial configuration and dimensioned for relative axial movement. The outer member has a wall defining an opening such as a longitudinal slot; an expanding member such as a leaf spring is connected to the inner member, the leaf spring being adapted to engage with the longitudinal slot so as to maintain rotational alignment between inner member and outer member.
摘要翻译： 提供导管组件，其具有内部构件和沿着纵向轴线延伸的外部构件，内部构件和外部构件具有同轴构造并且被设计成用于相对轴向移动。 外部构件具有限定诸如纵向狭槽的开口的壁; 诸如片簧的扩展构件连接到内部构件，板簧适于与纵向狭槽接合，以便保持内部构件和外部构件之间的旋转对准。
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