发明申请
US20090118261A1 QUINAZOLINONE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS
审中-公开
喹诺酮类衍生物及其作为B-RAF抑制剂的用途
- 专利标题： QUINAZOLINONE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS
- 专利标题（中）： 喹诺酮类衍生物及其作为B-RAF抑制剂的用途
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申请号： US11574031申请日： 2005-08-26
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公开(公告)号： US20090118261A1公开(公告)日： 2009-05-07
- 发明人: Brian Aquila , Leslie Dakin , Jayachandran Ezhuthachan , Stephen Lee , Paul Lyne , Timothy Pontz , XiaoLan Zheng
- 申请人： Brian Aquila , Leslie Dakin , Jayachandran Ezhuthachan , Stephen Lee , Paul Lyne , Timothy Pontz , XiaoLan Zheng
- 申请人地址： SE Sodertalje
- 专利权人： ASTRAZENECA AB
- 当前专利权人： ASTRAZENECA AB
- 当前专利权人地址： SE Sodertalje
- 国际申请： PCT/GB05/03334 WO 20050826
- 主分类号： A61K31/55
- IPC分类号： A61K31/55 ; C07D239/72 ; A61K31/517 ; C07D413/02 ; A61K31/5377 ; A61P35/00 ; C07D471/02 ; A61K31/519 ; A61K31/496 ; C07D403/02
摘要：
The invention relates to chemical compounds of the formula (I): or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.
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