Chemical Compounds-149
    2.
    发明申请
    Chemical Compounds-149 审中-公开
    化学成分-149

    公开(公告)号:US20080312206A1

    公开(公告)日:2008-12-18

    申请号:US12097652

    申请日:2006-12-19

    CPC分类号: C07D277/46 C07D417/12

    摘要: The invention relates to chemical compounds, or pharmaceutically acceptable salts thereof of the formula which possess CSF 1R kinase inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

    摘要翻译: 本发明涉及具有CSF 1R激酶抑制活性的化学化合物或其药学上可接受的盐,其具有CSF 1R激酶抑制活性,因此可用于其抗癌活性,因此可用于治疗人或动物体的方法。 本发明还涉及制备所述化合物的方法,含有它们的药物组合物及其在制备用于在温血动物如人中产生抗癌作用的药物中的用途。

    CHEMICAL COMPOUNDS
    9.
    发明申请
    CHEMICAL COMPOUNDS 审中-公开
    化学化合物

    公开(公告)号:US20090270450A1

    公开(公告)日:2009-10-29

    申请号:US12435856

    申请日:2009-05-05

    IPC分类号: A61K31/47 C07D215/44

    CPC分类号: C07D215/54 C07D401/04

    摘要: The invention relates to chemical compounds of formula (I): or pharmaceutically acceptable salts thereof which possess CSF-1R kinase inhibitory activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm-blooded animal such as man.

    摘要翻译: 本发明涉及具有CSF-1R激酶抑制活性的式(I)化合物或其药学上可接受的盐,因此可用于其抗癌活性,因此可用于治疗人或动物体的方法。 本发明还涉及制备所述化合物的方法,含有它们的药物组合物及其在制造用于在温血动物如人中产生抗癌作用的药物中的用途。

    3-CINNOLINECARBOXAMIDE DERIVATIVES AND THEIR USE FOR TREATING CANCER

    公开(公告)号:US20090012084A1

    公开(公告)日:2009-01-08

    申请号:US12210588

    申请日:2008-09-15

    CPC分类号: C07D237/28

    摘要: The invention relates to chemical compounds of formula (I): or pharmaceutically acceptable salts thereof which possess CSF-1R kinase inhibitory activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm-blooded animal such as man.

    摘要翻译: 本发明涉及具有CSF-1R激酶抑制活性的式(I)化合物或其药学上可接受的盐,因此可用于其抗癌活性,因此可用于治疗人或动物体的方法。 本发明还涉及制备所述化合物的方法,含有它们的药物组合物及其在制造用于在温血动物如人中产生抗癌作用的药物中的用途。