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公开(公告)号：US20090118261A1
公开(公告)日：2009-05-07
申请号：US11574031
申请日：2005-08-26
申请人： Brian Aquila , Leslie Dakin , Jayachandran Ezhuthachan , Stephen Lee , Paul Lyne , Timothy Pontz , XiaoLan Zheng
发明人： Brian Aquila , Leslie Dakin , Jayachandran Ezhuthachan , Stephen Lee , Paul Lyne , Timothy Pontz , XiaoLan Zheng
IPC分类号： A61K31/55 , C07D239/72 , A61K31/517 , C07D413/02 , A61K31/5377 , A61P35/00 , C07D471/02 , A61K31/519 , A61K31/496 , C07D403/02
CPC分类号： C07D471/04 , C07D239/90 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The invention relates to chemical compounds of the formula (I): or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.
摘要翻译： 本发明涉及具有B Raf抑制活性的式（I）化合物或其药学上可接受的盐，因此可用于其抗癌活性，因此可用于治疗人或动物体的方法。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在制备用于在温血动物如人中产生抗癌作用的药物中的用途。
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2.发明申请Quinazoline Derivatives, Process for Their Preparation and Their Use as Anti-Cancer Agents 审中-公开喹唑啉衍生物，其制备方法及其用作抗癌剂公开(公告)号：US20080306096A1
公开(公告)日：2008-12-11
申请号：US12097965
申请日：2006-12-19
IPC分类号： A61K31/517 , A61P35/00 , C07D239/94 , C07D403/12 , C07D405/02 , C07D409/02 , C07D401/02
CPC分类号： C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The invention relates to chemical compounds of the formula (I) or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.
摘要翻译： 本发明涉及具有B Raf抑制活性的式（I）化合物或其药学上可接受的盐，因此可用于其抗癌活性，因此可用于治疗人或动物体的方法。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在制备用于在温血动物如人中产生抗癌作用的药物中的用途。
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公开(公告)号：US20090099210A1
公开(公告)日：2009-04-16
申请号：US12340855
申请日：2008-12-22
申请人： Brian Aquila , Michael Howard Block , Audrey Davies , Jayachandran Ezhuthachan , Sandra Ann Filla , Timothy Pontz , Daniel John Russell , Maria-Elena Theoclitou , XiaoLan Zheng
发明人： Brian Aquila , Michael Howard Block , Audrey Davies , Jayachandran Ezhuthachan , Sandra Ann Filla , Timothy Pontz , Daniel John Russell , Maria-Elena Theoclitou , XiaoLan Zheng
IPC分类号： A61K31/519 , A61P35/00
CPC分类号： C07D498/04 , C07D513/04
摘要： This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.
摘要翻译： 本发明涉及具有结构式（I）的新化合物及其药物组合物及其使用方法。 这些新化合物提供癌症的治疗或预防。
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公开(公告)号：US20080153854A1
公开(公告)日：2008-06-26
申请号：US12032438
申请日：2008-02-15
申请人： Brian Aquila , Michael Howard Block , Audrey Davies , Jayachandran Ezhuthachan , Sandra Filla , Richard William Luke , Timothy Pontz , Daniel John Russell , Maria-Elena Theoclitou , XiaoLan Zheng
发明人： Brian Aquila , Michael Howard Block , Audrey Davies , Jayachandran Ezhuthachan , Sandra Filla , Richard William Luke , Timothy Pontz , Daniel John Russell , Maria-Elena Theoclitou , XiaoLan Zheng
IPC分类号： A61K31/519 , C07D487/04 , A61P35/00
CPC分类号： C07D513/04
摘要： This invention relates to novel compounds having the formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the specification and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.
摘要翻译： 本发明涉及具有式（I）的新化合物，其中R 1，R 2，R 3，R 4， R 5，R 5，R 6，R 7，R 8和R 9， SUP>如说明书及其药物组合物及其使用方法中所定义。 这些新化合物提供癌症的治疗或预防。
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5.发明申请Enantiomers of Selected Fused Pyrimidones and Uses in the Treatment and Prevention of Cancer 审中-公开所选融合嘧啶酮及其用途在治疗和预防癌症中的对映体公开(公告)号：US20080293744A1
公开(公告)日：2008-11-27
申请号：US11573683
申请日：2005-08-16
申请人： Brian Aquila , Michael Howard Block , Audrey Davies , Jayachandran Ezhuthachan , Timothy Pontz , Daniel John Russell , Marie-Elena Theoclitou , XiaoLan Zheng
发明人： Brian Aquila , Michael Howard Block , Audrey Davies , Jayachandran Ezhuthachan , Timothy Pontz , Daniel John Russell , Marie-Elena Theoclitou , XiaoLan Zheng
IPC分类号： A61K31/519 , C07D513/04 , A61P35/00
CPC分类号： C07D498/04 , C07D513/04
摘要： This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.
摘要翻译： 本发明涉及具有结构式（I）的新化合物及其药物组合物及其使用方法。 这些新化合物提供癌症的治疗或预防。
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公开(公告)号：US20060041129A1
公开(公告)日：2006-02-23
申请号：US11207128
申请日：2005-08-18
申请人： Brian Aquila , Michael Howard Block , Audrey Davies , Jayachandran Ezhuthachan , Timothy Pontz , Daniel John Russell , Maria-Elena Theoclitou , XiaoLan Zheng
发明人： Brian Aquila , Michael Howard Block , Audrey Davies , Jayachandran Ezhuthachan , Timothy Pontz , Daniel John Russell , Maria-Elena Theoclitou , XiaoLan Zheng
IPC分类号： A61K31/519 , C07D498/02 , C07D491/02
CPC分类号： C07D498/04 , C07D513/04
摘要： This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.
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公开(公告)号：US20080275022A1
公开(公告)日：2008-11-06
申请号：US11569918
申请日：2005-06-14
申请人： Brian Aquila , Les Dakin , Jayachandran Ezhuthachan , John Lee , Paul Lyne , Timothy Pontz
发明人： Brian Aquila , Les Dakin , Jayachandran Ezhuthachan , John Lee , Paul Lyne , Timothy Pontz
IPC分类号： A61K31/517 , C07D239/88 , C07D413/02 , A61K31/5377 , C07D403/02 , A61P35/00
CPC分类号： C07D239/91 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The invention relates to chemical compounds of the formula (I): or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.
摘要翻译： 本发明涉及具有B Raf抑制活性的式（I）化合物或其药学上可接受的盐，因此可用于其抗癌活性，因此可用于治疗人或动物体的方法。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在制备用于在温血动物如人中产生抗癌作用的药物中的用途。
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公开(公告)号：US07498333B2
公开(公告)日：2009-03-03
申请号：US11207128
申请日：2005-08-18
申请人： Brian Aquila , Michael Howard Block , Audrey Davies , Jayachandran Ezhuthachan , Sandra Ann Filla , Timothy Pontz , Daniel John Russell , Maria-Elena Theoclitou , XiaoLan Zheng
发明人： Brian Aquila , Michael Howard Block , Audrey Davies , Jayachandran Ezhuthachan , Sandra Ann Filla , Timothy Pontz , Daniel John Russell , Maria-Elena Theoclitou , XiaoLan Zheng
IPC分类号： C07D498/04 , A61K31/505
CPC分类号： C07D498/04 , C07D513/04
摘要： This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.
摘要翻译： 本发明涉及具有结构式（I）的新化合物及其药物组合物及其使用方法。 这些新化合物提供癌症的治疗或预防。
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公开(公告)号：US20070249636A1
公开(公告)日：2007-10-25
申请号：US11573671
申请日：2005-08-16
申请人： Brian Aquila , Michael Block , Audrey Davies , Jayachandran Ezhuthachan , Timothy Pontz , Daniel Russell , Marie-Elena Theoclitou , XiaoLan Zheng
发明人： Brian Aquila , Michael Block , Audrey Davies , Jayachandran Ezhuthachan , Timothy Pontz , Daniel Russell , Marie-Elena Theoclitou , XiaoLan Zheng
IPC分类号： A61K31/519 , A61P35/00 , C07D239/00 , C07D261/00 , C07D275/00 , C07D487/14 , C07D498/04 , C07D513/04
CPC分类号： C07D513/04
摘要： This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.
摘要翻译： 本发明涉及具有结构式（I）的新化合物及其药物组合物及其使用方法。 这些新化合物提供癌症的治疗或预防。
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公开(公告)号：US20060063751A1
公开(公告)日：2006-03-23
申请号：US11207089
申请日：2005-08-18
申请人： Brian Aquila , Michael Block , Audrey Davies , Jayachandran Ezhuthachan , Sandra Filla , Richard Luke , Timothy Pontz , Daniel Russell , Maria-Elena Theoclitou , XiaoLan Zheng
发明人： Brian Aquila , Michael Block , Audrey Davies , Jayachandran Ezhuthachan , Sandra Filla , Richard Luke , Timothy Pontz , Daniel Russell , Maria-Elena Theoclitou , XiaoLan Zheng
IPC分类号： A61K31/513 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D513/04
摘要： This invention relates to novel compounds having the formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the specification and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.
摘要翻译： 本发明涉及具有式（I）的新化合物，
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