发明申请
US20090155787A1 Mutations in the BCR-ABL tyrosine kinase associated with resistance to STI-571
有权
与STI-571抗性相关的BCR-ABL酪氨酸激酶突变
- 专利标题： Mutations in the BCR-ABL tyrosine kinase associated with resistance to STI-571
- 专利标题（中）： 与STI-571抗性相关的BCR-ABL酪氨酸激酶突变
-
申请号： US12080596申请日： 2008-04-04
-
公开(公告)号： US20090155787A1公开(公告)日： 2009-06-18
- 发明人: Charles L. Sawyers , Mercedes E. Gorre , Neil Pravin Shah , John Nicoll
- 申请人： Charles L. Sawyers , Mercedes E. Gorre , Neil Pravin Shah , John Nicoll
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12Q1/48
摘要：
The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
公开/授权文献
信息查询
