发明申请
- 专利标题: Polypeptides and Antibodies
- 专利标题(中): 多肽和抗体
-
申请号: US12417438申请日: 2009-04-02
-
公开(公告)号: US20090226438A1公开(公告)日: 2009-09-10
- 发明人: Brian Gliniak , Xiao-Dong Yang , Sharon Wong-Madden , Ian Foltz , Xiao Feng , Alison Fitch , Stephen Foster , Randal R. Ketchem
- 申请人: Brian Gliniak , Xiao-Dong Yang , Sharon Wong-Madden , Ian Foltz , Xiao Feng , Alison Fitch , Stephen Foster , Randal R. Ketchem
- 专利权人: Amgen Inc.
- 当前专利权人: Amgen Inc.
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; C07K16/00 ; C07K17/14 ; A61K39/44
摘要:
Polypeptides are provided. Antibodies or antigen binding domains are provided which bind such polypeptides. Also provided are methods of obtaining an antibody that binds tumor necrosis factor (TNF)-related apoptosis-inducing ligand (“TRAIL”) Receptor-2 (TR-2) comprising administering at least one of such polypeptides to an animal and obtaining an antibody that binds TR-2 from the animal. Antibodies reactive with TR-2 are provided. Also provided are cells producing antibodies reactive with TR-2, pharmaceutical compositions comprising antibodies reactive with TR-2, methods using antibodies reactive with TR-2, and kits comprising antibodies reactive with TR-2. Also provided are methods of decreasing or preventing binding of an antibody to TR-2 by administering such a polypeptide.