公开(公告)号：US20090226438A1

公开(公告)日：2009-09-10

申请号：US12417438

申请日：2009-04-02

申请人： Brian Gliniak ,  Xiao-Dong Yang ,  Sharon Wong-Madden ,  Ian Foltz ,  Xiao Feng ,  Alison Fitch ,  Stephen Foster ,  Randal R. Ketchem

发明人： Brian Gliniak ,  Xiao-Dong Yang ,  Sharon Wong-Madden ,  Ian Foltz ,  Xiao Feng ,  Alison Fitch ,  Stephen Foster ,  Randal R. Ketchem

IPC分类号： A61K39/395 ,  C07K16/00 ,  C07K17/14 ,  A61K39/44

CPC分类号： A61K39/39558 ,  A61K38/00 ,  C07K16/2878 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2317/92

摘要： Polypeptides are provided. Antibodies or antigen binding domains are provided which bind such polypeptides. Also provided are methods of obtaining an antibody that binds tumor necrosis factor (TNF)-related apoptosis-inducing ligand (“TRAIL”) Receptor-2 (TR-2) comprising administering at least one of such polypeptides to an animal and obtaining an antibody that binds TR-2 from the animal. Antibodies reactive with TR-2 are provided. Also provided are cells producing antibodies reactive with TR-2, pharmaceutical compositions comprising antibodies reactive with TR-2, methods using antibodies reactive with TR-2, and kits comprising antibodies reactive with TR-2. Also provided are methods of decreasing or preventing binding of an antibody to TR-2 by administering such a polypeptide.

摘要翻译： 提供多肽。 提供结合这些多肽的抗体或抗原结合结构域。 还提供了获得结合肿瘤坏死因子（TNF）相关的凋亡诱导配体（“TRAIL”）受体-2（TR-2）的抗体的方法，包括向动物施用至少一种这样的多肽并获得抗体 其结合来自动物的TR-2。 提供与TR-2反应的抗体。 还提供产生与TR-2反应的抗体的细胞，包含与TR-2反应的抗体的药物组合物，使用与TR-2反应的抗体的方法，以及包含与TR-2反应的抗体的试剂盒。 还提供了通过施用这样的多肽来降低或预防抗体与TR-2结合的方法。

公开(公告)号：US20070179086A1

公开(公告)日：2007-08-02

申请号：US11512051

申请日：2006-08-28

申请人： Brian Gliniak ,  Xiao-Dong Yang ,  Sharon Wong-Madden ,  Ian Foltz ,  Xiao Feng ,  Alison Fitch ,  Stephen Foster ,  Randal Ketchem

发明人： Brian Gliniak ,  Xiao-Dong Yang ,  Sharon Wong-Madden ,  Ian Foltz ,  Xiao Feng ,  Alison Fitch ,  Stephen Foster ,  Randal Ketchem

IPC分类号： A61K38/17 ,  C07K16/28 ,  C07K14/705 ,  C07H21/04 ,  C12P21/06

CPC分类号： A61K39/39558 ,  A61K38/00 ,  C07K16/2878 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2317/92

摘要： Polypeptides are provided. Antibodies or antigen binding domains are provided which bind such polypeptides. Also provided are methods of obtaining an antibody that binds tumor necrosis factor (TNF)-related apoptosis-inducing ligand (“TRAIL”) Receptor-2 (TR-2) comprising administering at least one of such polypeptides to an animal and obtaining an antibody that binds TR-2 from the animal. Antibodies reactive with TR-2 are provided. Also provided are cells producing antibodies reactive with TR-2, pharmaceutical compositions comprising antibodies reactive with TR-2, methods using antibodies reactive with TR-2, and kits comprising antibodies reactive with TR-2. Also provided are methods of decreasing or preventing binding of an antibody to TR-2 by administering such a polypeptide.

摘要翻译： 提供多肽。 提供结合这些多肽的抗体或抗原结合结构域。 还提供了获得结合肿瘤坏死因子（TNF）相关的凋亡诱导配体（“TRAIL”）受体-2（TR-2）的抗体的方法，包括向动物施用至少一种这样的多肽并获得抗体 其结合来自动物的TR-2。 提供与TR-2反应的抗体。 还提供产生与TR-2反应的抗体的细胞，包含与TR-2反应的抗体的药物组合物，使用与TR-2反应的抗体的方法，以及包含与TR-2反应的抗体的试剂盒。 还提供了通过施用这样的多肽来降低或预防抗体与TR-2结合的方法。

公开(公告)号：US20130101589A1

公开(公告)日：2013-04-25

申请号：US13607384

申请日：2012-09-07

申请人： Brian Gliniak ,  Xiao-Dong Yang ,  Sharon Wong-Madden ,  Ian Foltz ,  Xiao Feng ,  Alison Fitch ,  Stephen Foster ,  Randal R. Ketchem

发明人： Brian Gliniak ,  Xiao-Dong Yang ,  Sharon Wong-Madden ,  Ian Foltz ,  Xiao Feng ,  Alison Fitch ,  Stephen Foster ,  Randal R. Ketchem

IPC分类号： A61K39/395

CPC分类号： A61K39/39558 ,  A61K38/00 ,  C07K16/2878 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2317/92

摘要： Polypeptides are provided. Antibodies or antigen binding domains are provided which bind such polypeptides. Also provided are methods of obtaining an antibody that binds tumor necrosis factor (TNF)-related apoptosis-inducing ligand (“TRAIL”) Receptor-2 (TR-2) comprising administering at least one of such polypeptides to an animal and obtaining an antibody that binds TR-2 from the animal. Antibodies reactive with TR-2 are provided. Also provided are cells producing antibodies reactive with TR-2, pharmaceutical compositions comprising antibodies reactive with TR-2, methods using antibodies reactive with TR-2, and kits comprising antibodies reactive with TR-2. Also provided are methods of decreasing or preventing binding of an antibody to TR-2 by administering such a polypeptide.

摘要翻译： 提供多肽。 提供结合这些多肽的抗体或抗原结合结构域。 还提供了获得结合肿瘤坏死因子（TNF）相关的凋亡诱导配体（“TRAIL”）受体-2（TR-2）的抗体的方法，包括向动物施用至少一种这样的多肽并获得抗体 其结合来自动物的TR-2。 提供与TR-2反应的抗体。 还提供产生与TR-2反应的抗体的细胞，包含与TR-2反应的抗体的药物组合物，使用与TR-2反应的抗体的方法，以及包含与TR-2反应的抗体的试剂盒。 还提供了通过施用这样的多肽来降低或预防抗体与TR-2结合的方法。

公开(公告)号：US07521048B2

公开(公告)日：2009-04-21

申请号：US11512051

申请日：2006-08-28

申请人： Brian Gliniak ,  Xiao-Dong Yang ,  Sharon Wong-Madden ,  Ian Foltz ,  Xiao Feng ,  Alison Fitch ,  Stephen Foster ,  Randal R. Ketchem

发明人： Brian Gliniak ,  Xiao-Dong Yang ,  Sharon Wong-Madden ,  Ian Foltz ,  Xiao Feng ,  Alison Fitch ,  Stephen Foster ,  Randal R. Ketchem

IPC分类号： C12P21/08 ,  A61K39/00

CPC分类号： A61K39/39558 ,  A61K38/00 ,  C07K16/2878 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2317/92

摘要： Polypeptides are provided. Antibodies or antigen binding domains are provided which bind such polypeptides. Also provided are methods of obtaining an antibody that binds tumor necrosis factor (TNF)-related apoptosis-inducing ligand (“TRAIL”) Receptor-2 (TR-2) comprising administering at least one of such polypeptides to an animal and obtaining an antibody that binds TR-2 from the animal. Antibodies reactive with TR-2 are provided. Also provided are cells producing antibodies reactive with TR-2, pharmaceutical compositions comprising antibodies reactive with TR-2, methods using antibodies reactive with TR-2, and kits comprising antibodies reactive with TR-2. Also provided are methods of decreasing or preventing binding of an antibody to TR-2 by administering such a polypeptide.

摘要翻译： 提供多肽。 提供结合这些多肽的抗体或抗原结合结构域。 还提供了获得结合肿瘤坏死因子（TNF）相关的凋亡诱导配体（“TRAIL”）受体-2（TR-2）的抗体的方法，包括向动物施用至少一种这样的多肽并获得抗体 其结合来自动物的TR-2。 提供与TR-2反应的抗体。 还提供产生与TR-2反应的抗体的细胞，包含与TR-2反应的抗体的药物组合物，使用与TR-2反应的抗体的方法，以及包含与TR-2反应的抗体的试剂盒。 还提供了通过施用这样的多肽来降低或预防抗体与TR-2结合的方法。