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公开(公告)号:US20130101589A1
公开(公告)日:2013-04-25
申请号:US13607384
申请日:2012-09-07
申请人: Brian Gliniak , Xiao-Dong Yang , Sharon Wong-Madden , Ian Foltz , Xiao Feng , Alison Fitch , Stephen Foster , Randal R. Ketchem
发明人: Brian Gliniak , Xiao-Dong Yang , Sharon Wong-Madden , Ian Foltz , Xiao Feng , Alison Fitch , Stephen Foster , Randal R. Ketchem
IPC分类号: A61K39/395
CPC分类号: A61K39/39558 , A61K38/00 , C07K16/2878 , C07K2317/21 , C07K2317/24 , C07K2317/73 , C07K2317/92
摘要: Polypeptides are provided. Antibodies or antigen binding domains are provided which bind such polypeptides. Also provided are methods of obtaining an antibody that binds tumor necrosis factor (TNF)-related apoptosis-inducing ligand (“TRAIL”) Receptor-2 (TR-2) comprising administering at least one of such polypeptides to an animal and obtaining an antibody that binds TR-2 from the animal. Antibodies reactive with TR-2 are provided. Also provided are cells producing antibodies reactive with TR-2, pharmaceutical compositions comprising antibodies reactive with TR-2, methods using antibodies reactive with TR-2, and kits comprising antibodies reactive with TR-2. Also provided are methods of decreasing or preventing binding of an antibody to TR-2 by administering such a polypeptide.
摘要翻译: 提供多肽。 提供结合这些多肽的抗体或抗原结合结构域。 还提供了获得结合肿瘤坏死因子(TNF)相关的凋亡诱导配体(“TRAIL”)受体-2(TR-2)的抗体的方法,包括向动物施用至少一种这样的多肽并获得抗体 其结合来自动物的TR-2。 提供与TR-2反应的抗体。 还提供产生与TR-2反应的抗体的细胞,包含与TR-2反应的抗体的药物组合物,使用与TR-2反应的抗体的方法,以及包含与TR-2反应的抗体的试剂盒。 还提供了通过施用这样的多肽来降低或预防抗体与TR-2结合的方法。
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公开(公告)号:US08414895B2
公开(公告)日:2013-04-09
申请号:US12899397
申请日:2010-10-06
IPC分类号: A61K39/395
CPC分类号: A61K39/3955 , A61K38/00 , C07K14/705 , C07K14/70575 , C07K14/70578 , C07K16/2878 , C07K2319/00 , C07K2319/30 , C07K2319/73
摘要: The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue.
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公开(公告)号:US20120020918A1
公开(公告)日:2012-01-26
申请号:US13225326
申请日:2011-09-02
IPC分类号: A61K38/20 , A61P29/00 , A61P37/06 , A61P1/04 , A61P17/00 , A61P11/06 , A61P11/02 , A61P19/02 , C07K14/545 , A61P17/06
CPC分类号: C07K14/545 , A61K38/00 , A61K39/00 , C07K16/245 , C07K2317/75 , C12Q1/37 , G01N2333/545 , G01N2500/02 , G01N2500/20
摘要: The present invention provides compositions and methods relating to IL-1Rrp2 requiring proteins.
摘要翻译: 本发明提供了涉及需要蛋白质的IL-1Rrp2的组合物和方法。
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公开(公告)号:US20080124340A1
公开(公告)日:2008-05-29
申请号:US11786879
申请日:2007-04-13
IPC分类号: A61K39/395 , C07H21/04 , C12P21/06 , C12N5/06 , C07K16/28
CPC分类号: C07K16/2863 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/75 , C07K2317/92
摘要: Antibodies that bind erythropoietin receptor are provided. Methods of making and using such antibodies are also provided. Kits containing such antibodies are also provided.
摘要翻译: 提供了结合促红细胞生成素受体的抗体。 还提供了制备和使用这些抗体的方法。 还提供了含有此类抗体的试剂盒。
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公开(公告)号:US08722033B2
公开(公告)日:2014-05-13
申请号:US13504449
申请日:2010-10-26
申请人: Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
发明人: Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC分类号: C07K16/24 , A61K39/395
CPC分类号: C07K16/244 , A61K39/395 , A61K47/6845 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要: Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
摘要翻译: 提供了结合人IL-23蛋白的抗原结合蛋白。 还提供编码抗原结合蛋白,载体和编码相同的细胞以及用于诊断和治疗目的的IL-23抗原结合蛋白的使用的核酸。
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公开(公告)号:US07495086B2
公开(公告)日:2009-02-24
申请号:US10971250
申请日:2004-10-22
IPC分类号: C07K16/00
CPC分类号: A61K39/3955 , A61K38/00 , C07K14/705 , C07K14/70575 , C07K14/70578 , C07K16/2878 , C07K2319/00 , C07K2319/30 , C07K2319/73
摘要: The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue.
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公开(公告)号:US09487580B2
公开(公告)日:2016-11-08
申请号:US14228556
申请日:2014-03-28
申请人: Jennifer E. Towne , Janet D. Cheng , Jason C. O'neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
发明人: Jennifer E. Towne , Janet D. Cheng , Jason C. O'neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC分类号: A61K39/395 , C07K16/24 , A61K39/00
CPC分类号: C07K16/244 , A61K39/395 , A61K47/6845 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要: Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
摘要翻译: 提供了结合人IL-23蛋白的抗原结合蛋白。 还提供编码抗原结合蛋白,载体和编码相同的细胞以及用于诊断和治疗目的的IL-23抗原结合蛋白的使用的核酸。
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公开(公告)号:US20140212428A1
公开(公告)日:2014-07-31
申请号:US14228556
申请日:2014-03-28
申请人: Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
发明人: Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC分类号: C07K16/24
CPC分类号: C07K16/244 , A61K39/395 , A61K47/6845 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要: Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
摘要翻译: 提供了结合人IL-23蛋白的抗原结合蛋白。 还提供编码抗原结合蛋白,载体和编码相同的细胞以及用于诊断和治疗目的的IL-23抗原结合蛋白的使用的核酸。
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公开(公告)号:US20110150888A1
公开(公告)日:2011-06-23
申请号:US12990137
申请日:2009-04-28
IPC分类号: A61K39/395 , C12P21/04 , C12N5/10 , C12N15/63 , C07K16/18 , C07H21/04 , A61P29/00 , A61P7/06 , A61P35/00 , A61P9/00
CPC分类号: C07K16/26 , A61K38/1816 , A61K39/3955 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , A61K2300/00
摘要: The invention relates to monoclonal antibodies that bind hepcidin and methods of making and using such antibodies. Also provided are methods of treating hepcidin-related disorders.
摘要翻译: 本发明涉及结合铁调素的单克隆抗体以及制备和使用这些抗体的方法。 还提供了治疗铁调素相关病症的方法。
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公开(公告)号:US20090226438A1
公开(公告)日:2009-09-10
申请号:US12417438
申请日:2009-04-02
申请人: Brian Gliniak , Xiao-Dong Yang , Sharon Wong-Madden , Ian Foltz , Xiao Feng , Alison Fitch , Stephen Foster , Randal R. Ketchem
发明人: Brian Gliniak , Xiao-Dong Yang , Sharon Wong-Madden , Ian Foltz , Xiao Feng , Alison Fitch , Stephen Foster , Randal R. Ketchem
IPC分类号: A61K39/395 , C07K16/00 , C07K17/14 , A61K39/44
CPC分类号: A61K39/39558 , A61K38/00 , C07K16/2878 , C07K2317/21 , C07K2317/24 , C07K2317/73 , C07K2317/92
摘要: Polypeptides are provided. Antibodies or antigen binding domains are provided which bind such polypeptides. Also provided are methods of obtaining an antibody that binds tumor necrosis factor (TNF)-related apoptosis-inducing ligand (“TRAIL”) Receptor-2 (TR-2) comprising administering at least one of such polypeptides to an animal and obtaining an antibody that binds TR-2 from the animal. Antibodies reactive with TR-2 are provided. Also provided are cells producing antibodies reactive with TR-2, pharmaceutical compositions comprising antibodies reactive with TR-2, methods using antibodies reactive with TR-2, and kits comprising antibodies reactive with TR-2. Also provided are methods of decreasing or preventing binding of an antibody to TR-2 by administering such a polypeptide.
摘要翻译: 提供多肽。 提供结合这些多肽的抗体或抗原结合结构域。 还提供了获得结合肿瘤坏死因子(TNF)相关的凋亡诱导配体(“TRAIL”)受体-2(TR-2)的抗体的方法,包括向动物施用至少一种这样的多肽并获得抗体 其结合来自动物的TR-2。 提供与TR-2反应的抗体。 还提供产生与TR-2反应的抗体的细胞,包含与TR-2反应的抗体的药物组合物,使用与TR-2反应的抗体的方法,以及包含与TR-2反应的抗体的试剂盒。 还提供了通过施用这样的多肽来降低或预防抗体与TR-2结合的方法。
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