发明申请
US20090258403A1 NOVEL ALDOLASE, AND METHOD FOR PRODUCING OPTICALLY ACTIVE IHOG AND MONATIN
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新型ALDOLASE和用于生产光学活性的IHOG和MONATIN的方法
- 专利标题： NOVEL ALDOLASE, AND METHOD FOR PRODUCING OPTICALLY ACTIVE IHOG AND MONATIN
- 专利标题（中）： 新型ALDOLASE和用于生产光学活性的IHOG和MONATIN的方法
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申请号： US11953372申请日： 2007-12-10
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公开(公告)号： US20090258403A1公开(公告)日： 2009-10-15
- 发明人: Masakazu SUGIYAMA , Kunihiko Watanabe , Kenichi Mori , Hiroyuki Nozaki
- 申请人： Masakazu SUGIYAMA , Kunihiko Watanabe , Kenichi Mori , Hiroyuki Nozaki
- 申请人地址： JP Tokyo
- 专利权人： Ajinomoto Co., Inc.
- 当前专利权人： Ajinomoto Co., Inc.
- 当前专利权人地址： JP Tokyo
- 优先权： JP2004-169188 20040607; JP2004-375769 20041227
- 主分类号： C12P17/10
- IPC分类号： C12P17/10
摘要：
The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for producing optically active monatin, and aldolase used for these methods. As such, the present invention enables the synthesis of 4-(Indole-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid with high optical purity, which is useful as an intermediate in the synthesis of optically active monatin, from indole pyruvic acid and pyruvic acid (or oxaloacetic acid).