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1.发明申请NOVEL ALDOLASE, AND METHOD FOR PRODUCING OPTICALLY ACTIVE IHOG AND MONATIN 失效新型ALDOLASE和用于生产光学活性的IHOG和MONATIN的方法公开(公告)号：US20090258403A1
公开(公告)日：2009-10-15
申请号：US11953372
申请日：2007-12-10
IPC分类号： C12P17/10
摘要： The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for producing optically active monatin, and aldolase used for these methods. As such, the present invention enables the synthesis of 4-(Indole-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid with high optical purity, which is useful as an intermediate in the synthesis of optically active monatin, from indole pyruvic acid and pyruvic acid (or oxaloacetic acid).
摘要翻译： 本发明涉及一种用于制备光学活性的IHOG的方法，其可以用于制备莫纳甜。 本发明还涉及用于制备光学活性莫纳甜的方法和用于这些方法的醛缩酶。 因此，本发明能够合成具有高光学纯度的4-（吲哚-3-基甲基）-4-羟基-2-氧代戊二酸，其可用作在光学活性莫纳甜的合成中的吲哚丙酮酸的中间体 酸和丙酮酸（或草酰乙酸）。
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2.发明申请NOVEL ALDOLASE AND PRODUCTION PROCESS OF SUBSTITUTED ALPHA-KETO ACIDS 审中-公开新型ALDOLASE和替代ALPHA-KETO酸的生产方法公开(公告)号：US20130252310A1
公开(公告)日：2013-09-26
申请号：US13618272
申请日：2012-09-14
IPC分类号： C12N9/88
摘要： 4-(Indol-3-ylmethyl)-4-hydroxy-2-oxoglutarate, which is useful as an intermediate in the synthesis of monatin, may be synthesized from indole pyruvic acid and pyruvic acid (and/or oxaloacetic acid) by using a novel aldolase derived from the genus Pseudomonas, Erwinia, Flavobacterium, or Xanthomonas.
摘要翻译： 可用作合成莫纳甜的中间体的4-（吲哚-3-基甲基）-4-羟基-2-氧戊二酸，可以由吲哚丙酮酸和丙酮酸（和/或草酰乙酸）通过使用 衍生自假单胞菌属，欧文氏菌属，黄杆菌属或黄单胞菌属的新型醛缩酶。
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公开(公告)号：US20130157342A1
公开(公告)日：2013-06-20
申请号：US13533317
申请日：2012-06-26
IPC分类号： C12N9/88
摘要： 4-(Indol-3-ylmethyl)-4-hydroxy-2-oxoglutarate, which is useful as an intermediate in the synthesis of monatin, may be synthesized from indole pyruvic acid and pyruvic acid (and/or oxaloacetic acid) by using a novel aldolase derived from the genus Pseudomonas, Erwinia, Flavobacterium, or Xanthomonas.
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公开(公告)号：US20100261234A1
公开(公告)日：2010-10-14
申请号：US12768360
申请日：2010-04-27
申请人： Masakazu SUGIYAMA , Kunihiko Watanabe , Nao Funakoshi , Yusuke Amino , Shigeru Kawahara , Tadashi Takemoto
发明人： Masakazu SUGIYAMA , Kunihiko Watanabe , Nao Funakoshi , Yusuke Amino , Shigeru Kawahara , Tadashi Takemoto
IPC分类号： C12P17/10
摘要： The present invention relates to a process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin by converting a substituted α-keto acid of formula (1) into a glutamic acid derivative of formula (2) in the presence of an enzyme catalyzing conversion of the same.
摘要翻译： 本发明涉及通过在式（2）的存在下将式（1）的取代的α-酮酸转化为式（2）的谷氨酸衍生物而有效地制备谷氨酸衍生物（包括其盐）如莫纳甜的方法 催化其转化。
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公开(公告)号：US20110189738A1
公开(公告)日：2011-08-04
申请号：US13044618
申请日：2011-03-10
申请人： Masakazu SUGIYAMA , Kunihiko WATANABE , Nao FUNAKOSHI , Yusuke AMINO , Shigeru KAWAHARA , Tadashi TAKEMOTO
发明人： Masakazu SUGIYAMA , Kunihiko WATANABE , Nao FUNAKOSHI , Yusuke AMINO , Shigeru KAWAHARA , Tadashi TAKEMOTO
IPC分类号： C12P13/04
摘要： The present invention relates to a process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin by converting a substituted α-keto acid of formula (1) into a glutamic acid derivative of formula (2) in the presence of an enzyme catalyzing conversion of the same.
摘要翻译： 本发明涉及通过在式（2）的存在下将式（1）的取代的α-酮酸转化为式（2）的谷氨酸衍生物而有效地制备谷氨酸衍生物（包括其盐）如莫纳甜的方法 催化其转化。
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6.发明申请公开(公告)号：US20100255548A1
公开(公告)日：2010-10-07
申请号：US12758433
申请日：2010-04-12
IPC分类号： C12P13/04
CPC分类号： C12N9/1096 , C12P17/10
摘要： A D-aminotransferase can be modified so as to efficiently produce (2R,4R)-monatin having high sweetness intensity from 4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid by substituting an amino acid at least at one of positions (positions 100, 180 to 183, 243 and 244) involved in efficiently producing the (2R,4R)-monatin in an amino acid sequence of a wild-type D-aminotransferase represented in SEQ ID NO:2.
摘要翻译： 可以修饰D-氨基转移酶，以便通过用氨基酸至少在4-（吲哚-3-基甲基）-4-羟基-2-氧代戊二酸代替氨基酸，有效地产生具有高甜度强度的（2R，4R） 在SEQ ID NO：2所示的野生型D-氨基转移酶的氨基酸序列中有效产生（2R，4R） - 单抗的位置（位置100,180〜183,243和244）之一。
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7.发明申请公开(公告)号：US20080193975A1
公开(公告)日：2008-08-14
申请号：US12055605
申请日：2008-03-26
CPC分类号： C12N9/1096 , C12P17/10
摘要： A D-aminotransferase can be modified so as to efficiently produce (2R,4R)-monatin having high sweetness intensity from 4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid by mutating the amino acid sequence of a wild-type D-aminotransferase represented in SEQ ID NO:4.
摘要翻译： 可以对D-氨基转移酶进行修饰，从而通过突变a-氨基酸的氨基酸序列，有效地产生4-（吲哚-3-基甲基）-4-羟基-2-氧代戊二酸具有高甜度强度的（2R，4R） SEQ ID NO：4所示的野生型D-氨基转移酶。
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8.发明申请NOVEL ALDOLASE AND PRODUCTION PROCESS OF SUBSTITUTED ALPHA-KETO ACIDS 失效新型ALDOLASE和替代ALPHA-KETO酸的生产方法公开(公告)号：US20080318290A1
公开(公告)日：2008-12-25
申请号：US11960116
申请日：2007-12-19
摘要： 4-(Indol-3-ylmethyl)-4-hydroxy-2-oxoglutarate, which is useful as an intermediate in the synthesis of monatin, may be synthesized from indole pyruvic acid and pyruvic acid (and/or oxalacetic acid) by using a novel aldolase derived from the genus Pseudomonas, Erwinia, Flavobacterium, or Xanthomonas.
摘要翻译： 可用作合成莫纳甜的中间体的4-（吲哚-3-基甲基）-4-羟基-2-氧戊二酸，可以由吲哚丙酮酸和丙酮酸（和/或草乙酸）通过使用 衍生自假单胞菌属，欧文氏菌属，黄杆菌属或黄单胞菌属的新型醛缩酶。
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9.发明申请NOVEL ALDOLASE AND PRODUCTION PROCESS OF SUBSTITUTED ALPHA-KETO ACIDS 失效新型ALDOLASE和替代ALPHA-KETO酸的生产方法公开(公告)号：US20120040416A1
公开(公告)日：2012-02-16
申请号：US13250359
申请日：2011-09-30
摘要： 4-(Indol-3-ylmethyl)-4-hydroxy-2-oxoglutarate, which is useful as an intermediate in the synthesis of monatin, may be synthesized from indole pyruvic acid and pyruvic acid (and/or oxaloacetic acid) by using a novel aldolase derived from the genus Pseudomonas, Erwinia, Flavobacterium, or Xanthomonas.
摘要翻译： 可用作合成莫纳甜的中间体的4-（吲哚-3-基甲基）-4-羟基-2-氧戊二酸，可以由吲哚丙酮酸和丙酮酸（和/或草酰乙酸）通过使用 衍生自假单胞菌属，欧文氏菌属，黄杆菌属或黄单胞菌属的新型醛缩酶。
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公开(公告)号：US20120308765A1
公开(公告)日：2012-12-06
申请号：US13566092
申请日：2012-08-03
申请人： Osamu NUKAGA , Seiji SAMUKAWA , Masakazu SUGIYAMA
发明人： Osamu NUKAGA , Seiji SAMUKAWA , Masakazu SUGIYAMA
CPC分类号： B23K26/0624 , B23K26/0006 , B23K26/384 , B23K26/389 , B23K26/40 , B23K26/53 , B23K26/55 , B23K2103/50 , H01L21/30604 , H01L21/30608 , H01L21/3065 , Y10T428/24
摘要： A nanostructure forming method includes: preparing a substrate having an appropriate processing value; applying laser beam having a pulse duration of picosecond order or less to a planar surface oriented in a propagation direction of the laser beam and a direction perpendicular to a polarization direction (electric field direction) of the laser beam in the interior of the substrate at an irradiation intensity which is close to the appropriate processing value of the substrate; forming a structure-modified portion at a focus at which the laser beam is concentrated and in a region which is close to the focus; and forming a nanostructure formed of a nano-hole by selectively etching the structure-modified portion.
摘要翻译： 纳米结构形成方法包括：制备具有适当处理值的基材; 对于在激光束的传播方向上定向的平面表面和垂直于基板内部的激光束的偏振方向（电场方向）的方向，施加具有皮秒级或更小脉冲持续时间的激光束， 接近基板的适当处理值的照射强度; 在激光束集中的焦点处和在靠近焦点的区域中形成结构改性部分; 以及通过选择性地蚀刻所述结构改性部分，形成由纳米孔形成的纳米结构。
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